ID   STAT_ANOGA              Reviewed;         722 AA.
AC   Q7QDU4; O97164;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   27-MAR-2024, entry version 129.
DE   RecName: Full=Signal transducer and transcription activator;
DE   AltName: Full=Ag-STAT;
GN   Name=Stat; ORFNames=AGAP010423;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:CAA09070.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY,
RP   DEVELOPMENTAL STAGE, AND INDUCTION.
RC   STRAIN=G3 {ECO:0000312|EMBL:CAA09070.1};
RX   PubMed=10022838; DOI=10.1093/emboj/18.4.959;
RA   Barillas-Mury C., Han Y.-S., Seeley D., Kafatos F.C.;
RT   "Anopheles gambiae Ag-STAT, a new insect member of the STAT family is
RT   activated in response to bacterial infection.";
RL   EMBO J. 18:959-967(1999).
RN   [2] {ECO:0000305, ECO:0000312|EMBL:EAA07203.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000312|EMBL:EAA07203.1};
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- FUNCTION: Signal transduction and activation of transcription. Plays an
CC       important role in the segmental pattern formation in the early embryo
CC       by activating specific stripes of pair rule gene expression (By
CC       similarity). The STAT pathway directly participates in immune responses
CC       in insects. {ECO:0000250|UniProtKB:Q24151,
CC       ECO:0000269|PubMed:10022838}.
CC   -!- SUBUNIT: Forms a homodimer or a heterodimer with a related family
CC       member. {ECO:0000250|UniProtKB:P51692}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Translocated into the nucleus in response to phosphorylation.
CC       {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in hemocytes, pericardial cells, midgut,
CC       skeletal muscle and fat body cells. {ECO:0000269|PubMed:10022838}.
CC   -!- DEVELOPMENTAL STAGE: Expressed at all developmental stages.
CC       {ECO:0000269|PubMed:10022838}.
CC   -!- INDUCTION: Bacterial challenge results in nuclear translocation in fat
CC       body cells and induction of DNA-binding activity that recognizes a STAT
CC       target site. In vitro treatment with pervanadate (vanadate and
CC       H(2)O(2)) translocates protein to the nucleus in midgut epithelial
CC       cells. {ECO:0000269|PubMed:10022838}.
CC   -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC       {ECO:0000255}.
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DR   EMBL; AJ010299; CAA09070.1; -; Genomic_DNA.
DR   EMBL; AAAB01008849; EAA07203.1; -; Genomic_DNA.
DR   RefSeq; XP_311525.1; XM_311525.1.
DR   AlphaFoldDB; Q7QDU4; -.
DR   SMR; Q7QDU4; -.
DR   STRING; 7165.Q7QDU4; -.
DR   PaxDb; 7165-AGAP010423-PA; -.
DR   EnsemblMetazoa; AGAP010423-RA; AGAP010423-PA; AGAP010423.
DR   GeneID; 1272625; -.
DR   KEGG; aga:AgaP_AGAP010423; -.
DR   CTD; 1272625; -.
DR   VEuPathDB; VectorBase:AGAP010423; -.
DR   eggNOG; KOG3667; Eukaryota.
DR   HOGENOM; CLU_014189_2_0_1; -.
DR   InParanoid; Q7QDU4; -.
DR   OMA; HKSHWND; -.
DR   OrthoDB; 7823at2759; -.
DR   PhylomeDB; Q7QDU4; -.
DR   Proteomes; UP000007062; Chromosome 3L.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006952; P:defense response; IBA:GO_Central.
DR   GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR   GO; GO:0042127; P:regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd09919; SH2_STAT_family; 1.
DR   CDD; cd14801; STAT_DBD; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR   Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR   Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR001217; STAT.
DR   InterPro; IPR048988; STAT_linker.
DR   InterPro; IPR036535; STAT_N_sf.
DR   InterPro; IPR013800; STAT_TF_alpha.
DR   InterPro; IPR015988; STAT_TF_coiled-coil.
DR   InterPro; IPR013801; STAT_TF_DNA-bd.
DR   InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR   InterPro; IPR013799; STAT_TF_prot_interaction.
DR   PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR   PANTHER; PTHR11801:SF43; SIGNAL TRANSDUCER AND TRANSCRIPTION ACTIVATOR; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF01017; STAT_alpha; 1.
DR   Pfam; PF02864; STAT_bind; 1.
DR   Pfam; PF21354; STAT_linker; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00964; STAT_int; 1.
DR   SUPFAM; SSF49417; p53-like transcription factors; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF47655; STAT; 1.
DR   SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cytoplasm; Developmental protein; DNA-binding; Nucleus;
KW   Phosphoprotein; Reference proteome; SH2 domain; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..722
FT                   /note="Signal transducer and transcription activator"
FT                   /id="PRO_0000233907"
FT   DOMAIN          545..644
FT                   /note="SH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT   REGION          667..689
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        155
FT                   /note="Q -> H (in Ref. 1; CAA09070)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        176
FT                   /note="N -> Y (in Ref. 1; CAA09070)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        311
FT                   /note="T -> S (in Ref. 1; CAA09070)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        547
FT                   /note="D -> N (in Ref. 1; CAA09070)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        684
FT                   /note="T -> A (in Ref. 1; CAA09070)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        687..689
FT                   /note="NDM -> KDT (in Ref. 1; CAA09070)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   722 AA;  83879 MW;  BB106241A28F36CC CRC64;
     METRLHQLPP CILEQFHFLN DLKYPVLIRQ HLGNWIKDSL HNAPTYTNNM QSMYELDAAK
     FFTALVNEVD QVSANLPNKR KCLLCRSAIM LRDQNFQNLT QLYLTLLHQI QPNCEKGCKT
     EYTIAQTSSD GQQTDVLYGL QQLHVMERNN WKETQQLIQE CEQDHVQRLS NQRSHNKRIQ
     CYSLKQRSLV DAFQKTIRKA EEVLNLVYNK YIFEWQKTQM FPEVRSTNAY SLDEIQTWYE
     SLAAIMWNTK DQIHLTMKSQ LREHVSQEIN SDLWKVMKDV KDFIKLLLHK AFIVENQPPQ
     VMKMNTRFCA TVRLLIDNAL IMKIGNPKVT VSIISETQAQ QIQSTNAAAD FSAGEIENNI
     GNLQYQLSNK FLANFSNMRL KKINRGNRKL NKLVVDEKFA LLFQSSFTLE QEELTVTVWT
     LSLPAVVIVH VNQEQLAWTT IIWDNLCAKA DRKLFEVPNL IPWNRLVEAI SMTFSARVGR
     GLTDENMQYM YRKAYRDKLS FSVSNDQMIS FAQFCKDTTP ECNYTFWEWL YAALKIIRDH
     LQVLWVDNTI IGFIHKSTAE KYLAKCVPGT FLLRFTDSVL GGISIAWVHE SNDGQRQVLH
     IQPFTAKDLV VRSLANRICD LGELTYLYPT IPKQEAFGRY TAPAIQKPRS KHYISAEMRT
     VLIFAPSSNQ SSSSTPNAEQ SPSTSSNDMF SNEYVLTNLD EIYKFEIEND DMLSIQDYWE
     QQ
//