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Q7QDU4

- STAT_ANOGA

UniProt

Q7QDU4 - STAT_ANOGA

Protein

Signal transducer and transcription activator

Gene

Stat

Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Signal transduction and activation of transcription. Plays an important role in the segmental pattern formation in the early embryo by activating specific stripes of pair rule gene expression By similarity. The STAT pathway directly participates in immune responses in insects.By similarity1 Publication

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. DNA binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: InterPro
    4. signal transducer activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Signal transducer and transcription activator
    Alternative name(s):
    Ag-STAT
    Gene namesi
    Name:Stat
    ORF Names:AGAP010423
    OrganismiAnopheles gambiae (African malaria mosquito)
    Taxonomic identifieri7165 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
    ProteomesiUP000007062: Chromosome 3L

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Translocated into the nucleus in response to phosphorylation.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 722722Signal transducer and transcription activatorPRO_0000233907Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Tissue specificityi

    Expressed in hemocytes, pericardial cells, midgut, skeletal muscle and fat body cells.1 Publication

    Developmental stagei

    Expressed at all developmental stages.1 Publication

    Inductioni

    Bacterial challenge results in nuclear translocation in fat body cells and induction of DNA-binding activity that recognizes a STAT target site. In vitro treatment with pervanadate (vanadate and H2O2) translocates protein to the nucleus in midgut epithelial cells.1 Publication

    Interactioni

    Subunit structurei

    Forms a homodimer or a heterodimer with a related family member.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ7QDU4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini545 – 644100SH2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the transcription factor STAT family.Sequence Analysis
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiNOG245085.
    HOGENOMiHOG000230988.
    InParanoidiQ7QDU4.
    OMAiYALIVEN.
    OrthoDBiEOG73JKTT.
    PhylomeDBiQ7QDU4.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.10.532.10. 1 hit.
    1.20.1050.20. 1 hit.
    2.60.40.630. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR008967. p53-like_TF_DNA-bd.
    IPR000980. SH2.
    IPR001217. STAT.
    IPR013800. STAT_TF_alpha.
    IPR015988. STAT_TF_coiled-coil.
    IPR013801. STAT_TF_DNA-bd.
    IPR012345. STAT_TF_DNA-bd_sub.
    IPR013799. STAT_TF_prot_interaction.
    [Graphical view]
    PANTHERiPTHR11801. PTHR11801. 1 hit.
    PfamiPF00017. SH2. 1 hit.
    PF02864. STAT_bind. 1 hit.
    [Graphical view]
    SMARTiSM00252. SH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF47655. SSF47655. 1 hit.
    SSF48092. SSF48092. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7QDU4-1 [UniParc]FASTAAdd to Basket

    « Hide

    METRLHQLPP CILEQFHFLN DLKYPVLIRQ HLGNWIKDSL HNAPTYTNNM    50
    QSMYELDAAK FFTALVNEVD QVSANLPNKR KCLLCRSAIM LRDQNFQNLT 100
    QLYLTLLHQI QPNCEKGCKT EYTIAQTSSD GQQTDVLYGL QQLHVMERNN 150
    WKETQQLIQE CEQDHVQRLS NQRSHNKRIQ CYSLKQRSLV DAFQKTIRKA 200
    EEVLNLVYNK YIFEWQKTQM FPEVRSTNAY SLDEIQTWYE SLAAIMWNTK 250
    DQIHLTMKSQ LREHVSQEIN SDLWKVMKDV KDFIKLLLHK AFIVENQPPQ 300
    VMKMNTRFCA TVRLLIDNAL IMKIGNPKVT VSIISETQAQ QIQSTNAAAD 350
    FSAGEIENNI GNLQYQLSNK FLANFSNMRL KKINRGNRKL NKLVVDEKFA 400
    LLFQSSFTLE QEELTVTVWT LSLPAVVIVH VNQEQLAWTT IIWDNLCAKA 450
    DRKLFEVPNL IPWNRLVEAI SMTFSARVGR GLTDENMQYM YRKAYRDKLS 500
    FSVSNDQMIS FAQFCKDTTP ECNYTFWEWL YAALKIIRDH LQVLWVDNTI 550
    IGFIHKSTAE KYLAKCVPGT FLLRFTDSVL GGISIAWVHE SNDGQRQVLH 600
    IQPFTAKDLV VRSLANRICD LGELTYLYPT IPKQEAFGRY TAPAIQKPRS 650
    KHYISAEMRT VLIFAPSSNQ SSSSTPNAEQ SPSTSSNDMF SNEYVLTNLD 700
    EIYKFEIEND DMLSIQDYWE QQ 722
    Length:722
    Mass (Da):83,879
    Last modified:December 15, 2003 - v1
    Checksum:iBB106241A28F36CC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti155 – 1551Q → H in CAA09070. (PubMed:10022838)Curated
    Sequence conflicti176 – 1761N → Y in CAA09070. (PubMed:10022838)Curated
    Sequence conflicti311 – 3111T → S in CAA09070. (PubMed:10022838)Curated
    Sequence conflicti547 – 5471D → N in CAA09070. (PubMed:10022838)Curated
    Sequence conflicti684 – 6841T → A in CAA09070. (PubMed:10022838)Curated
    Sequence conflicti687 – 6893NDM → KDT in CAA09070. (PubMed:10022838)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ010299 Genomic DNA. Translation: CAA09070.1.
    AAAB01008849 Genomic DNA. Translation: EAA07203.1.
    RefSeqiXP_311525.1. XM_311525.1.

    Genome annotation databases

    EnsemblMetazoaiAGAP010423-RA; AGAP010423-PA; AGAP010423.
    GeneIDi1272625.
    KEGGiaga:AgaP_AGAP010423.
    VectorBaseiAGAP010424. Anopheles gambiae.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ010299 Genomic DNA. Translation: CAA09070.1 .
    AAAB01008849 Genomic DNA. Translation: EAA07203.1 .
    RefSeqi XP_311525.1. XM_311525.1.

    3D structure databases

    ProteinModelPortali Q7QDU4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai AGAP010423-RA ; AGAP010423-PA ; AGAP010423 .
    GeneIDi 1272625.
    KEGGi aga:AgaP_AGAP010423.
    VectorBasei AGAP010424. Anopheles gambiae.

    Organism-specific databases

    CTDi 1272625.

    Phylogenomic databases

    eggNOGi NOG245085.
    HOGENOMi HOG000230988.
    InParanoidi Q7QDU4.
    OMAi YALIVEN.
    OrthoDBi EOG73JKTT.
    PhylomeDBi Q7QDU4.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.10.532.10. 1 hit.
    1.20.1050.20. 1 hit.
    2.60.40.630. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR008967. p53-like_TF_DNA-bd.
    IPR000980. SH2.
    IPR001217. STAT.
    IPR013800. STAT_TF_alpha.
    IPR015988. STAT_TF_coiled-coil.
    IPR013801. STAT_TF_DNA-bd.
    IPR012345. STAT_TF_DNA-bd_sub.
    IPR013799. STAT_TF_prot_interaction.
    [Graphical view ]
    PANTHERi PTHR11801. PTHR11801. 1 hit.
    Pfami PF00017. SH2. 1 hit.
    PF02864. STAT_bind. 1 hit.
    [Graphical view ]
    SMARTi SM00252. SH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47655. SSF47655. 1 hit.
    SSF48092. SSF48092. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Anopheles gambiae Ag-STAT, a new insect member of the STAT family is activated in response to bacterial infection."
      Barillas-Mury C., Han Y.-S., Seeley D., Kafatos F.C.
      EMBO J. 18:959-967(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
      Strain: G3Imported.
    2. "The genome sequence of the malaria mosquito Anopheles gambiae."
      Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F.
      , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
      Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PESTImported.

    Entry informationi

    Entry nameiSTAT_ANOGA
    AccessioniPrimary (citable) accession number: Q7QDU4
    Secondary accession number(s): O97164
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3