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Q7QDU4 (STAT_ANOGA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Signal transducer and transcription activator
Alternative name(s):
Ag-STAT
Gene names
Name:Stat
ORF Names:AGAP010423
OrganismAnopheles gambiae (African malaria mosquito) [Reference proteome]
Taxonomic identifier7165 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles

Protein attributes

Sequence length722 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Signal transduction and activation of transcription. Plays an important role in the segmental pattern formation in the early embryo by activating specific stripes of pair rule gene expression By similarity. The STAT pathway directly participates in immune responses in insects. Ref.1 UniProtKB Q24151

Subunit structure

Forms a homodimer or a heterodimer with a related family member By similarity. UniProtKB P51692

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: Translocated into the nucleus in response to phosphorylation By similarity.

Tissue specificity

Expressed in hemocytes, pericardial cells, midgut, skeletal muscle and fat body cells. Ref.1

Developmental stage

Expressed at all developmental stages. Ref.1

Induction

Bacterial challenge results in nuclear translocation in fat body cells and induction of DNA-binding activity that recognizes a STAT target site. In vitro treatment with pervanadate (vanadate and H2O2) translocates protein to the nucleus in midgut epithelial cells. Ref.1

Sequence similarities

Belongs to the transcription factor STAT family.

Contains 1 SH2 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 722722Signal transducer and transcription activator
PRO_0000233907

Regions

Domain545 – 644100SH2

Experimental info

Sequence conflict1551Q → H in CAA09070. Ref.1
Sequence conflict1761N → Y in CAA09070. Ref.1
Sequence conflict3111T → S in CAA09070. Ref.1
Sequence conflict5471D → N in CAA09070. Ref.1
Sequence conflict6841T → A in CAA09070. Ref.1
Sequence conflict687 – 6893NDM → KDT in CAA09070. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q7QDU4 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: BB106241A28F36CC

FASTA72283,879
        10         20         30         40         50         60 
METRLHQLPP CILEQFHFLN DLKYPVLIRQ HLGNWIKDSL HNAPTYTNNM QSMYELDAAK 

        70         80         90        100        110        120 
FFTALVNEVD QVSANLPNKR KCLLCRSAIM LRDQNFQNLT QLYLTLLHQI QPNCEKGCKT 

       130        140        150        160        170        180 
EYTIAQTSSD GQQTDVLYGL QQLHVMERNN WKETQQLIQE CEQDHVQRLS NQRSHNKRIQ 

       190        200        210        220        230        240 
CYSLKQRSLV DAFQKTIRKA EEVLNLVYNK YIFEWQKTQM FPEVRSTNAY SLDEIQTWYE 

       250        260        270        280        290        300 
SLAAIMWNTK DQIHLTMKSQ LREHVSQEIN SDLWKVMKDV KDFIKLLLHK AFIVENQPPQ 

       310        320        330        340        350        360 
VMKMNTRFCA TVRLLIDNAL IMKIGNPKVT VSIISETQAQ QIQSTNAAAD FSAGEIENNI 

       370        380        390        400        410        420 
GNLQYQLSNK FLANFSNMRL KKINRGNRKL NKLVVDEKFA LLFQSSFTLE QEELTVTVWT 

       430        440        450        460        470        480 
LSLPAVVIVH VNQEQLAWTT IIWDNLCAKA DRKLFEVPNL IPWNRLVEAI SMTFSARVGR 

       490        500        510        520        530        540 
GLTDENMQYM YRKAYRDKLS FSVSNDQMIS FAQFCKDTTP ECNYTFWEWL YAALKIIRDH 

       550        560        570        580        590        600 
LQVLWVDNTI IGFIHKSTAE KYLAKCVPGT FLLRFTDSVL GGISIAWVHE SNDGQRQVLH 

       610        620        630        640        650        660 
IQPFTAKDLV VRSLANRICD LGELTYLYPT IPKQEAFGRY TAPAIQKPRS KHYISAEMRT 

       670        680        690        700        710        720 
VLIFAPSSNQ SSSSTPNAEQ SPSTSSNDMF SNEYVLTNLD EIYKFEIEND DMLSIQDYWE 


QQ 

« Hide

References

« Hide 'large scale' references
[1]"Anopheles gambiae Ag-STAT, a new insect member of the STAT family is activated in response to bacterial infection."
Barillas-Mury C., Han Y.-S., Seeley D., Kafatos F.C.
EMBO J. 18:959-967(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
Strain: G3.
[2]"The genome sequence of the malaria mosquito Anopheles gambiae."
Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F. expand/collapse author list , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PEST.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ010299 Genomic DNA. Translation: CAA09070.1.
AAAB01008849 Genomic DNA. Translation: EAA07203.1.
RefSeqXP_311525.1. XM_311525.1.

3D structure databases

ProteinModelPortalQ7QDU4.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaAGAP010423-RA; AGAP010423-PA; AGAP010423.
GeneID1272625.
KEGGaga:AgaP_AGAP010423.
VectorBaseAGAP010424. Anopheles gambiae.

Phylogenomic databases

eggNOGNOG245085.
HOGENOMHOG000230988.
InParanoidQ7QDU4.
OMAYALIVEN.
OrthoDBEOG73JKTT.
PhylomeDBQ7QDU4.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERPTHR11801. PTHR11801. 1 hit.
PfamPF00017. SH2. 1 hit.
PF02864. STAT_bind. 1 hit.
[Graphical view]
SMARTSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSTAT_ANOGA
AccessionPrimary (citable) accession number: Q7QDU4
Secondary accession number(s): O97164
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families