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Q7QDU4

- STAT_ANOGA

UniProt

Q7QDU4 - STAT_ANOGA

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Protein

Signal transducer and transcription activator

Gene
Stat, AGAP010423
Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Signal transduction and activation of transcription. Plays an important role in the segmental pattern formation in the early embryo by activating specific stripes of pair rule gene expression By similarity. The STAT pathway directly participates in immune responses in insects.By similarity1 Publication

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. DNA binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
  4. signal transducer activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and transcription activator
Alternative name(s):
Ag-STAT
Gene namesi
Name:Stat
ORF Names:AGAP010423
OrganismiAnopheles gambiae (African malaria mosquito)
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
ProteomesiUP000007062: Chromosome 3L

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Translocated into the nucleus in response to phosphorylation By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 722722Signal transducer and transcription activatorPRO_0000233907Add
BLAST

Keywords - PTMi

Phosphoprotein

Expressioni

Tissue specificityi

Expressed in hemocytes, pericardial cells, midgut, skeletal muscle and fat body cells.1 Publication

Developmental stagei

Expressed at all developmental stages.1 Publication

Inductioni

Bacterial challenge results in nuclear translocation in fat body cells and induction of DNA-binding activity that recognizes a STAT target site. In vitro treatment with pervanadate (vanadate and H2O2) translocates protein to the nucleus in midgut epithelial cells.1 Publication

Interactioni

Subunit structurei

Forms a homodimer or a heterodimer with a related family member By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ7QDU4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini545 – 644100SH2Add
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG245085.
HOGENOMiHOG000230988.
InParanoidiQ7QDU4.
OMAiYALIVEN.
OrthoDBiEOG73JKTT.
PhylomeDBiQ7QDU4.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF02864. STAT_bind. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7QDU4-1 [UniParc]FASTAAdd to Basket

« Hide

METRLHQLPP CILEQFHFLN DLKYPVLIRQ HLGNWIKDSL HNAPTYTNNM    50
QSMYELDAAK FFTALVNEVD QVSANLPNKR KCLLCRSAIM LRDQNFQNLT 100
QLYLTLLHQI QPNCEKGCKT EYTIAQTSSD GQQTDVLYGL QQLHVMERNN 150
WKETQQLIQE CEQDHVQRLS NQRSHNKRIQ CYSLKQRSLV DAFQKTIRKA 200
EEVLNLVYNK YIFEWQKTQM FPEVRSTNAY SLDEIQTWYE SLAAIMWNTK 250
DQIHLTMKSQ LREHVSQEIN SDLWKVMKDV KDFIKLLLHK AFIVENQPPQ 300
VMKMNTRFCA TVRLLIDNAL IMKIGNPKVT VSIISETQAQ QIQSTNAAAD 350
FSAGEIENNI GNLQYQLSNK FLANFSNMRL KKINRGNRKL NKLVVDEKFA 400
LLFQSSFTLE QEELTVTVWT LSLPAVVIVH VNQEQLAWTT IIWDNLCAKA 450
DRKLFEVPNL IPWNRLVEAI SMTFSARVGR GLTDENMQYM YRKAYRDKLS 500
FSVSNDQMIS FAQFCKDTTP ECNYTFWEWL YAALKIIRDH LQVLWVDNTI 550
IGFIHKSTAE KYLAKCVPGT FLLRFTDSVL GGISIAWVHE SNDGQRQVLH 600
IQPFTAKDLV VRSLANRICD LGELTYLYPT IPKQEAFGRY TAPAIQKPRS 650
KHYISAEMRT VLIFAPSSNQ SSSSTPNAEQ SPSTSSNDMF SNEYVLTNLD 700
EIYKFEIEND DMLSIQDYWE QQ 722
Length:722
Mass (Da):83,879
Last modified:December 15, 2003 - v1
Checksum:iBB106241A28F36CC
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti155 – 1551Q → H in CAA09070. 1 Publication
Sequence conflicti176 – 1761N → Y in CAA09070. 1 Publication
Sequence conflicti311 – 3111T → S in CAA09070. 1 Publication
Sequence conflicti547 – 5471D → N in CAA09070. 1 Publication
Sequence conflicti684 – 6841T → A in CAA09070. 1 Publication
Sequence conflicti687 – 6893NDM → KDT in CAA09070. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ010299 Genomic DNA. Translation: CAA09070.1.
AAAB01008849 Genomic DNA. Translation: EAA07203.1.
RefSeqiXP_311525.1. XM_311525.1.

Genome annotation databases

EnsemblMetazoaiAGAP010423-RA; AGAP010423-PA; AGAP010423.
GeneIDi1272625.
KEGGiaga:AgaP_AGAP010423.
VectorBaseiAGAP010424. Anopheles gambiae.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ010299 Genomic DNA. Translation: CAA09070.1 .
AAAB01008849 Genomic DNA. Translation: EAA07203.1 .
RefSeqi XP_311525.1. XM_311525.1.

3D structure databases

ProteinModelPortali Q7QDU4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai AGAP010423-RA ; AGAP010423-PA ; AGAP010423 .
GeneIDi 1272625.
KEGGi aga:AgaP_AGAP010423.
VectorBasei AGAP010424. Anopheles gambiae.

Organism-specific databases

CTDi 1272625.

Phylogenomic databases

eggNOGi NOG245085.
HOGENOMi HOG000230988.
InParanoidi Q7QDU4.
OMAi YALIVEN.
OrthoDBi EOG73JKTT.
PhylomeDBi Q7QDU4.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view ]
PANTHERi PTHR11801. PTHR11801. 1 hit.
Pfami PF00017. SH2. 1 hit.
PF02864. STAT_bind. 1 hit.
[Graphical view ]
SMARTi SM00252. SH2. 1 hit.
[Graphical view ]
SUPFAMi SSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEi PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Anopheles gambiae Ag-STAT, a new insect member of the STAT family is activated in response to bacterial infection."
    Barillas-Mury C., Han Y.-S., Seeley D., Kafatos F.C.
    EMBO J. 18:959-967(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
    Strain: G3.
  2. "The genome sequence of the malaria mosquito Anopheles gambiae."
    Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F.
    , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
    Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PEST.

Entry informationi

Entry nameiSTAT_ANOGA
AccessioniPrimary (citable) accession number: Q7QDU4
Secondary accession number(s): O97164
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 15, 2003
Last modified: September 3, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3