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Protein

Signal transducer and transcription activator

Gene

Stat

Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Signal transduction and activation of transcription. Plays an important role in the segmental pattern formation in the early embryo by activating specific stripes of pair rule gene expression (By similarity). The STAT pathway directly participates in immune responses in insects.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and transcription activator
Alternative name(s):
Ag-STAT
Gene namesi
Name:Stat
ORF Names:AGAP010423
OrganismiAnopheles gambiae (African malaria mosquito)
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
ProteomesiUP000007062 Componenti: Chromosome 3L

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Translocated into the nucleus in response to phosphorylation.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 722722Signal transducer and transcription activatorPRO_0000233907Add
BLAST

Keywords - PTMi

Phosphoprotein

Expressioni

Tissue specificityi

Expressed in hemocytes, pericardial cells, midgut, skeletal muscle and fat body cells.1 Publication

Developmental stagei

Expressed at all developmental stages.1 Publication

Inductioni

Bacterial challenge results in nuclear translocation in fat body cells and induction of DNA-binding activity that recognizes a STAT target site. In vitro treatment with pervanadate (vanadate and H2O2) translocates protein to the nucleus in midgut epithelial cells.1 Publication

Interactioni

Subunit structurei

Forms a homodimer or a heterodimer with a related family member.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ7QDU4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini545 – 644100SH2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the transcription factor STAT family.Sequence Analysis
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG245085.
HOGENOMiHOG000230988.
InParanoidiQ7QDU4.
OMAiHYISAEM.
OrthoDBiEOG73JKTT.
PhylomeDBiQ7QDU4.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF02864. STAT_bind. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7QDU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METRLHQLPP CILEQFHFLN DLKYPVLIRQ HLGNWIKDSL HNAPTYTNNM
60 70 80 90 100
QSMYELDAAK FFTALVNEVD QVSANLPNKR KCLLCRSAIM LRDQNFQNLT
110 120 130 140 150
QLYLTLLHQI QPNCEKGCKT EYTIAQTSSD GQQTDVLYGL QQLHVMERNN
160 170 180 190 200
WKETQQLIQE CEQDHVQRLS NQRSHNKRIQ CYSLKQRSLV DAFQKTIRKA
210 220 230 240 250
EEVLNLVYNK YIFEWQKTQM FPEVRSTNAY SLDEIQTWYE SLAAIMWNTK
260 270 280 290 300
DQIHLTMKSQ LREHVSQEIN SDLWKVMKDV KDFIKLLLHK AFIVENQPPQ
310 320 330 340 350
VMKMNTRFCA TVRLLIDNAL IMKIGNPKVT VSIISETQAQ QIQSTNAAAD
360 370 380 390 400
FSAGEIENNI GNLQYQLSNK FLANFSNMRL KKINRGNRKL NKLVVDEKFA
410 420 430 440 450
LLFQSSFTLE QEELTVTVWT LSLPAVVIVH VNQEQLAWTT IIWDNLCAKA
460 470 480 490 500
DRKLFEVPNL IPWNRLVEAI SMTFSARVGR GLTDENMQYM YRKAYRDKLS
510 520 530 540 550
FSVSNDQMIS FAQFCKDTTP ECNYTFWEWL YAALKIIRDH LQVLWVDNTI
560 570 580 590 600
IGFIHKSTAE KYLAKCVPGT FLLRFTDSVL GGISIAWVHE SNDGQRQVLH
610 620 630 640 650
IQPFTAKDLV VRSLANRICD LGELTYLYPT IPKQEAFGRY TAPAIQKPRS
660 670 680 690 700
KHYISAEMRT VLIFAPSSNQ SSSSTPNAEQ SPSTSSNDMF SNEYVLTNLD
710 720
EIYKFEIEND DMLSIQDYWE QQ
Length:722
Mass (Da):83,879
Last modified:December 15, 2003 - v1
Checksum:iBB106241A28F36CC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti155 – 1551Q → H in CAA09070 (PubMed:10022838).Curated
Sequence conflicti176 – 1761N → Y in CAA09070 (PubMed:10022838).Curated
Sequence conflicti311 – 3111T → S in CAA09070 (PubMed:10022838).Curated
Sequence conflicti547 – 5471D → N in CAA09070 (PubMed:10022838).Curated
Sequence conflicti684 – 6841T → A in CAA09070 (PubMed:10022838).Curated
Sequence conflicti687 – 6893NDM → KDT in CAA09070 (PubMed:10022838).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010299 Genomic DNA. Translation: CAA09070.1.
AAAB01008849 Genomic DNA. Translation: EAA07203.1.
RefSeqiXP_311525.1. XM_311525.1.

Genome annotation databases

EnsemblMetazoaiAGAP010423-RA; AGAP010423-PA; AGAP010423.
GeneIDi1272625.
KEGGiaga:AgaP_AGAP010423.
VectorBaseiAGAP010424. Anopheles gambiae.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010299 Genomic DNA. Translation: CAA09070.1.
AAAB01008849 Genomic DNA. Translation: EAA07203.1.
RefSeqiXP_311525.1. XM_311525.1.

3D structure databases

ProteinModelPortaliQ7QDU4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAGAP010423-RA; AGAP010423-PA; AGAP010423.
GeneIDi1272625.
KEGGiaga:AgaP_AGAP010423.
VectorBaseiAGAP010424. Anopheles gambiae.

Organism-specific databases

CTDi1272625.

Phylogenomic databases

eggNOGiNOG245085.
HOGENOMiHOG000230988.
InParanoidiQ7QDU4.
OMAiHYISAEM.
OrthoDBiEOG73JKTT.
PhylomeDBiQ7QDU4.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF02864. STAT_bind. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Anopheles gambiae Ag-STAT, a new insect member of the STAT family is activated in response to bacterial infection."
    Barillas-Mury C., Han Y.-S., Seeley D., Kafatos F.C.
    EMBO J. 18:959-967(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
    Strain: G3Imported.
  2. "The genome sequence of the malaria mosquito Anopheles gambiae."
    Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F.
    , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
    Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PESTImported.

Entry informationi

Entry nameiSTAT_ANOGA
AccessioniPrimary (citable) accession number: Q7QDU4
Secondary accession number(s): O97164
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 15, 2003
Last modified: March 4, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.