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Protein

Signal transducer and transcription activator

Gene

Stat

Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Signal transduction and activation of transcription. Plays an important role in the segmental pattern formation in the early embryo by activating specific stripes of pair rule gene expression (By similarity). The STAT pathway directly participates in immune responses in insects.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and transcription activator
Alternative name(s):
Ag-STAT
Gene namesi
Name:Stat
ORF Names:AGAP010423
OrganismiAnopheles gambiae (African malaria mosquito)
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
Proteomesi
  • UP000007062 Componentsi: Chromosome 3L, Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002339071 – 722Signal transducer and transcription activatorAdd BLAST722

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7QDU4
PRIDEiQ7QDU4

Expressioni

Tissue specificityi

Expressed in hemocytes, pericardial cells, midgut, skeletal muscle and fat body cells.1 Publication

Developmental stagei

Expressed at all developmental stages.1 Publication

Inductioni

Bacterial challenge results in nuclear translocation in fat body cells and induction of DNA-binding activity that recognizes a STAT target site. In vitro treatment with pervanadate (vanadate and H2O2) translocates protein to the nucleus in midgut epithelial cells.1 Publication

Interactioni

Subunit structurei

Forms a homodimer or a heterodimer with a related family member.By similarity

Protein-protein interaction databases

STRINGi7165.AGAP010423-PA

Structurei

3D structure databases

ProteinModelPortaliQ7QDU4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini545 – 644SH2PROSITE-ProRule annotationAdd BLAST100

Sequence similaritiesi

Belongs to the transcription factor STAT family.Sequence analysis

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG3667 Eukaryota
ENOG410XPN8 LUCA
HOGENOMiHOG000230988
InParanoidiQ7QDU4
KOiK11224
OMAiWYNMLTT
PhylomeDBiQ7QDU4

Family and domain databases

Gene3Di2.60.40.630, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR036535 STAT_N_sf
IPR013800 STAT_TF_alpha
IPR015988 STAT_TF_coiled-coil
IPR013801 STAT_TF_DNA-bd
IPR012345 STAT_TF_DNA-bd_N
IPR013799 STAT_TF_prot_interaction
PANTHERiPTHR11801 PTHR11801, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF01017 STAT_alpha, 1 hit
PF02864 STAT_bind, 1 hit
PF02865 STAT_int, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00964 STAT_int, 1 hit
SUPFAMiSSF47655 SSF47655, 1 hit
SSF48092 SSF48092, 1 hit
SSF49417 SSF49417, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7QDU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METRLHQLPP CILEQFHFLN DLKYPVLIRQ HLGNWIKDSL HNAPTYTNNM
60 70 80 90 100
QSMYELDAAK FFTALVNEVD QVSANLPNKR KCLLCRSAIM LRDQNFQNLT
110 120 130 140 150
QLYLTLLHQI QPNCEKGCKT EYTIAQTSSD GQQTDVLYGL QQLHVMERNN
160 170 180 190 200
WKETQQLIQE CEQDHVQRLS NQRSHNKRIQ CYSLKQRSLV DAFQKTIRKA
210 220 230 240 250
EEVLNLVYNK YIFEWQKTQM FPEVRSTNAY SLDEIQTWYE SLAAIMWNTK
260 270 280 290 300
DQIHLTMKSQ LREHVSQEIN SDLWKVMKDV KDFIKLLLHK AFIVENQPPQ
310 320 330 340 350
VMKMNTRFCA TVRLLIDNAL IMKIGNPKVT VSIISETQAQ QIQSTNAAAD
360 370 380 390 400
FSAGEIENNI GNLQYQLSNK FLANFSNMRL KKINRGNRKL NKLVVDEKFA
410 420 430 440 450
LLFQSSFTLE QEELTVTVWT LSLPAVVIVH VNQEQLAWTT IIWDNLCAKA
460 470 480 490 500
DRKLFEVPNL IPWNRLVEAI SMTFSARVGR GLTDENMQYM YRKAYRDKLS
510 520 530 540 550
FSVSNDQMIS FAQFCKDTTP ECNYTFWEWL YAALKIIRDH LQVLWVDNTI
560 570 580 590 600
IGFIHKSTAE KYLAKCVPGT FLLRFTDSVL GGISIAWVHE SNDGQRQVLH
610 620 630 640 650
IQPFTAKDLV VRSLANRICD LGELTYLYPT IPKQEAFGRY TAPAIQKPRS
660 670 680 690 700
KHYISAEMRT VLIFAPSSNQ SSSSTPNAEQ SPSTSSNDMF SNEYVLTNLD
710 720
EIYKFEIEND DMLSIQDYWE QQ
Length:722
Mass (Da):83,879
Last modified:December 15, 2003 - v1
Checksum:iBB106241A28F36CC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti155Q → H in CAA09070 (PubMed:10022838).Curated1
Sequence conflicti176N → Y in CAA09070 (PubMed:10022838).Curated1
Sequence conflicti311T → S in CAA09070 (PubMed:10022838).Curated1
Sequence conflicti547D → N in CAA09070 (PubMed:10022838).Curated1
Sequence conflicti684T → A in CAA09070 (PubMed:10022838).Curated1
Sequence conflicti687 – 689NDM → KDT in CAA09070 (PubMed:10022838).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010299 Genomic DNA Translation: CAA09070.1
AAAB01008849 Genomic DNA Translation: EAA07203.1
RefSeqiXP_311525.1, XM_311525.1

Genome annotation databases

EnsemblMetazoaiAGAP010423-RA; AGAP010423-PA; AGAP010423
GeneIDi1272625
KEGGiaga:AgaP_AGAP010423
VectorBaseiAGAP010423-RA; AGAP010423-PA; AGAP010423

Similar proteinsi

Entry informationi

Entry nameiSTAT_ANOGA
AccessioniPrimary (citable) accession number: Q7QDU4
Secondary accession number(s): O97164
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 15, 2003
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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