Q7QDK6 (Q7QDK6_ANOGA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Adenylosuccinate synthetase RuleBase RU000520
EC=6.3.4.4 RuleBase RU000520

Gene names

ORF Names:

AgaP_AGAP003405 EMBL EAA07403.5

Organism

Anopheles gambiae (African malaria mosquito)

Taxonomic identifier

7165 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Anophelinae › Anopheles

Protein attributes

Sequence length	466 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the de novo pathway of purine nucleotide biosynthesis By similarity. RuleBase RU000520
Catalytic activity	GTP + IMP + L-aspartate = GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP. RuleBase RU000520
Pathway	Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. RuleBase RU000520
Sequence similarities	Belongs to the adenylosuccinate synthetase family. RuleBase RU004163
Caution	The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. EMBL EAA07403.5

Ontologies

Keywords
Biological process	Purine biosynthesis RuleBase RU000520
Ligand	GTP-binding RuleBase RU000520 Magnesium RuleBase RU000520 Metal-binding RuleBase RU000520 Nucleotide-binding
Molecular function	Ligase RuleBase RU000520
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylosuccinate synthase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7QDK6 [UniParc]. Last modified July 27, 2011. Version 5. Checksum: B39E8EEA7DB3D0F2	FASTA	466	51,043
	10 20 30 40 50 60 MSAANHQMAV NGTANHNSSD SNHTAANNTH EQMHNRRQNP YTQKVTVVLG AQWGDEGKGK 70 80 90 100 110 120 VVDMLAADAD IVCRCQGGNN AGHTVVVNGV DFDFHLLPSG IIHEKCISII GNGVVVHLPG 130 140 150 160 170 180 LFEELAKNEA KGLKNWTDRL IISNRAHLVL DLHQQVDGLQ EAEKGGKSLG TTKKGIGPCY 190 200 210 220 230 240 SSKATRNGIR VSDLLGDFKM FSEKFEALVA MYKRLYPDFS VDVNAELARY REYAERLRPL 250 260 270 280 290 300 VRDSVSYLHT SLKEGKSVLV EGANAAMLDI DFGTYPYVTS SNCSIGGVLT GLGLPPQSIG 310 320 330 340 350 360 EVIGVVKAYT TRVGDGPFPT ELLDEIGSLL QKRGGEVGVT TQRIRRCGWL DLPLLRYTSM 370 380 390 400 410 420 VNGYTAICLT KLDILDTLKE IKVAVSYNLN GKKIDYFPGS ITDLSQVEVN YVTVPGWLQC 430 440 450 460 TENVRDFGEL PPQAQDYIRF IESDLDVPVK WIGVGKGRES IICVKD

References

[1]

"The genome sequence of the malaria mosquito Anopheles gambiae." Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F. , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L. Science 298:129-149(2002) [PubMed: 12364791] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PEST.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAAB01008851 Genomic DNA. Translation: EAA07403.5.
RefSeq	XP_311692.5. XM_311692.5.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q7QDK6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1272781.
KEGG	aga:AgaP_AGAP003405.
Phylogenomic databases
OMA	YVLGIIK.
PhylomeDB	Q7QDK6.
Family and domain databases
HAMAP	MF_00011. Adenylosucc_synth. [Tree]
InterPro	IPR018220. Adenylosuccinate_synthase_AS. IPR001114. Adenylosuccinate_synthetase. [Graphical view]
KO	K01939.
PANTHER	PTHR11846. Asucc_synthtase. 1 hit.
Pfam	PF00709. Adenylsucc_synt. 1 hit. [Graphical view]
SMART	SM00788. Adenylsucc_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR00184. PurA. 1 hit.
PROSITE	PS01266. ADENYLOSUCCIN_SYN_1. 1 hit. PS00513. ADENYLOSUCCIN_SYN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q7QDK6_ANOGA

Accession

Primary (citable) accession number: Q7QDK6

Entry history

Integrated into UniProtKB/TrEMBL:	December 15, 2003
Last sequence update:	July 27, 2011
Last modified:	December 14, 2011
This is version 66 of the entry and version 5 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)