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Protein

Odorant receptor coreceptor

Gene

Orco

Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Odorant coreceptor which complexes with conventional odorant receptors (ORs) to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Orco is a universal and integral part of the functional odorant receptor, involved in the dendritic localization of other olfactory receptors. Can form functional ion channels in the absence of an odor-binding OR. Plays a key role in preferred attraction of females for humans over non-human hosts for blood feeding. Human attraction plays a crucial role in the transmission of Plasmodium protozoans by the mosquito leading to infection diseases like malaria. Also required for the response to N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide.5 Publications

Miscellaneous

The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways. The homomeric Orco channel is thought to be a cyclic-nucleotide-gated ion channel that depolarizes the olfactory receptor neuron. While many natural and synthetic odorants have been shown to agonize Orco/Or complexes, only a single direct Orco agonist, VUAA1, has been described. On the contrary, amiloride derivatives block Orco/Or complexes.

GO - Molecular functioni

  • odorant binding Source: InterPro
  • olfactory receptor activity Source: UniProtKB
  • taste receptor activity Source: UniProtKB

GO - Biological processi

  • behavior Source: UniProtKB-KW
  • sensory perception of smell Source: UniProtKB
  • sensory perception of taste Source: UniProtKB

Keywordsi

Molecular functionReceptor, Transducer
Biological processBehavior, Olfaction, Sensory transduction

Names & Taxonomyi

Protein namesi
Recommended name:
Odorant receptor coreceptor
Alternative name(s):
AgOr7
Gustatory and odorant receptor 7
Gene namesi
Name:Orco
Synonyms:GPRor7
ORF Names:AGAP002560
OrganismiAnopheles gambiae (African malaria mosquito)
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
Proteomesi
  • UP000007062 Componentsi: Chromosome 2R, Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41CytoplasmicSequence analysisAdd BLAST41
Transmembranei42 – 62Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini63 – 73ExtracellularSequence analysisAdd BLAST11
Transmembranei74 – 94Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini95 – 133CytoplasmicSequence analysisAdd BLAST39
Transmembranei134 – 154Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini155 – 188ExtracellularSequence analysisAdd BLAST34
Transmembranei189 – 209Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini210 – 338CytoplasmicSequence analysisAdd BLAST129
Transmembranei339 – 361Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini362 – 382ExtracellularSequence analysisAdd BLAST21
Transmembranei383 – 403Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini404 – 454CytoplasmicSequence analysisAdd BLAST51
Transmembranei455 – 475Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini476 – 478ExtracellularSequence analysis3

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002963731 – 478Odorant receptor coreceptorAdd BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7QCC7.

Expressioni

Tissue specificityi

Expressed in olfactory and gustatory organs of both adult and immature stages. Highest expression is seen in adult antennae and the maxillary palps. Lower expression also seen in proboscis and legs. Within the antenna, expression originates in cell bodies and projects into the lumen of an individual sensillum, presumably along the dendritic extension of the neuron. Within the maxillary palps, expression is seen in a small number of cell bodies and in projections into the sensillar cone. Within the probiscus, expression is seen in a single type of sensillum on the outer surface of the labellar lobes.1 Publication

Developmental stagei

Expressed in preimago stages, including early stage larvae, late-stage larvae, and pupae, but not in embryos.1 Publication

Interactioni

Subunit structurei

Heterodimer with conventional odorant receptors (ORs). Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway.

Protein-protein interaction databases

STRINGi7165.AGAP002560-PA.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK8M. Eukaryota.
ENOG4110PZW. LUCA.
HOGENOMiHOG000115286.
InParanoidiQ7QCC7.
KOiK08471.
OMAiQIYYVLF.
OrthoDBiEOG091G0JOZ.
PhylomeDBiQ7QCC7.

Family and domain databases

InterProiView protein in InterPro
IPR004117. 7tm6_olfct_rcpt.
PANTHERiPTHR21137. PTHR21137. 1 hit.
PfamiView protein in Pfam
PF02949. 7tm_6. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7QCC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVQPTKYVG LVADLMPNIR LMQASGHFLF RYVTGPILIR KVYSWWTLAM
60 70 80 90 100
VLIQFFAILG NLATNADDVN ELTANTITTL FFTHSVTKFI YFAVNSENFY
110 120 130 140 150
RTLAIWNQTN THPLFAESDA RYHSIALAKM RKLLVLVMAT TVLSVVAWVT
160 170 180 190 200
ITFFGESVKT VLDKATNETY TVDIPRLPIK SWYPWNAMSG PAYIFSFIYQ
210 220 230 240 250
IYFLLFSMVQ SNLADVMFCS WLLLACEQLQ HLKGIMRSLM ELSASLDTYR
260 270 280 290 300
PNSSQLFRAI SAGSKSELII NEEKDPDVKD FDLSGIYSSK ADWGAQFRAP
310 320 330 340 350
STLQTFDENG RNGNPNGLTR KQEMMVRSAI KYWVERHKHV VRLVSAIGDT
360 370 380 390 400
YGPALLLHML TSTIKLTLLA YQATKIDGVN VYGLTVIGYL CYALAQVFLF
410 420 430 440 450
CIFGNRLIEE SSSVMEAAYS CHWYDGSEEA KTFVQIVCQQ CQKAMTISGA
460 470
KFFTVSLDLF ASVLGAVVTY FMVLVQLK
Length:478
Mass (Da):54,020
Last modified:January 9, 2007 - v3
Checksum:i88514EB621C9F8C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY363725 mRNA. Translation: AAR14938.1.
AY363726 Genomic DNA. Translation: AAR14939.1.
AY843205 mRNA. Translation: AAX14774.1.
AAAB01008859 Genomic DNA. Translation: EAA08038.3.
RefSeqiXP_312379.3. XM_312379.3.

Genome annotation databases

EnsemblMetazoaiAGAP002560-RA; AGAP002560-PA; AGAP002560.
GeneIDi1273405.
KEGGiaga:AgaP_AGAP002560.
VectorBaseiAGAP002560-RA; AGAP002560-PA; AGAP002560.

Similar proteinsi

Entry informationi

Entry nameiORCO_ANOGA
AccessioniPrimary (citable) accession number: Q7QCC7
Secondary accession number(s): Q6UR07, Q6UR08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: January 9, 2007
Last modified: November 22, 2017
This is version 84 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families