Reviewed, UniProtKB/Swiss-Prot Q7QC84 (MMSA_ANOGA)

Names and origin

Protein names

Recommended name:
    Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
      Short name=MMSDH
      Short name=Malonate-semialdehyde dehydrogenase [acylating]
    EC=1.2.1.27
    EC=1.2.1.18

Gene names

ORF Names:

AGAP002499

Organism

Anopheles gambiae (African malaria mosquito) [Complete proteome]

Taxonomic identifier

7165 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Anophelinae › Anopheles

Protein attributes

Sequence length	521 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA By similarity.
Catalytic activity	2-methyl-3-oxopropanoate + CoA + H(2)O + NAD(+) = propanoyl-CoA + HCO(3)(-) + NADH. 3-oxopropanoate + CoA + NAD(P)(+) = acetyl-CoA + CO(2) + NAD(P)H.
Subunit structure	Homotetramer By similarity.
Subcellular location	MitochondrionBy similarity.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW valine metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	malonate-semialdehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: EC methylmalonate-semialdehyde dehydrogenase (acylating) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 521		Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial		PRO_0000043372
Regions
	Nucleotide binding	196 – 200	5	NAD Potential
	Nucleotide binding	248 – 253	6	NAD Potential
Sites
	Active site	304	1	Nucleophile By similarity
	Binding site	404	1	NAD Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7QC84-1 [UniParc]. Last modified December 7, 2004. Version 2. Checksum: C32B9871C0464F42	FASTA	521	56,714
	10 20 30 40 50 60 MALLRLVATE CRNVLQRGYS TASVPTTKMF IDGKFVESKT NDWIDLHDPA TNEVVTRVPK 70 80 90 100 110 120 CTQDEMQTAV ESSKKAYKTW RQSSILSRQQ VMLKLQHIIR NNMSELAKNI TKEQGKTLID 130 140 150 160 170 180 AEGDVLRGLQ VVEHCCSITS LQMGETVPNI AKDMDTYSYH LPLGVTAGIA PFNFPAMIPL 190 200 210 220 230 240 WMFPVAITCG NTSIIKPSER VPGATMLLME MLNEAGCPPG VVNVIHGAHD AVNFVCDNPD 250 260 270 280 290 300 IRAVSFVGSD QAGKYIYERA GRNGKRVQCN MGAKNHGVIM ADANKENTLN QLAGAAFGAA 310 320 330 340 350 360 GQRCMALSTA VFVGEARNWI PDLVERARKL KVNAGHLPGT DLGPVISPQS KQRINELVES 370 380 390 400 410 420 GAKEGAKIVL DGRNIKVEGF EKGNFVGPTI ISDVTPNMKC YTEEIFGPVL VCLSVDTIDE 430 440 450 460 470 480 AIELINNNPY GNGTAIFTTN GATARKFVND IDVGQVGVNV PIPVPLPMFS FTGSRGSFLG 490 500 510 520 DCHFYGKQGI KFYTQTKTVT QLWREGDVSH TKAAVAMPTM K

References

[1]

"The genome sequence of the malaria mosquito Anopheles gambiae." Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F. , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L. Science 298:129-149(2002) [PubMed: 12364791] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PEST.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAAB01008859 Genomic DNA. Translation: EAA07972.4.
RefSeq	XP_312441.4.
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	AGAP002499. Anopheles gambiae. [Contig view]
GeneID	1273463.
KEGG	aga:AgaP_AGAP002499.
VectorBase	AGAP002499. Anopheles gambiae.
Phylogenomic databases
HOGENOM	Q7QC84.
Family and domain databases
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. IPR010061. MeMal-semiAld_DHase. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit. PTHR11699:SF27. MMSDH. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01722. MMSDH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MMSA_ANOGA

Accession

Primary (citable) accession number: Q7QC84

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	December 7, 2004
Last modified:	November 25, 2008
This is version 40 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)