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Q7QC84 (MMSA_ANOGA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
Short name=MMSDH
Short name=Malonate-semialdehyde dehydrogenase [acylating]
EC=1.2.1.18
EC=1.2.1.27
Gene names
ORF Names:AGAP002499
OrganismAnopheles gambiae (African malaria mosquito)
Taxonomic identifier7165 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Anophelinae › Anopheles

Protein attributes

Sequence length521 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA By similarity. UniProtKB Q02252

Catalytic activity

2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH. UniProtKB P42412

3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H. UniProtKB Q02252

Subunit structure

Homotetramer By similarity. UniProtKB Q02252

Subcellular location

Mitochondrion By similarity UniProtKB Q02252.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 521Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrialPRO_0000043372

Regions

Nucleotide binding196 – 2005NAD Potential
Nucleotide binding248 – 2536NAD Potential

Sites

Active site3041Nucleophile By similarity UniProtKB Q02252
Binding site4041NAD Potential

Sequences

Sequence LengthMass (Da)Tools
Q7QC84 [UniParc].

Last modified December 7, 2004. Version 2.
Checksum: C32B9871C0464F42

FASTA52156,714
        10         20         30         40         50         60 
MALLRLVATE CRNVLQRGYS TASVPTTKMF IDGKFVESKT NDWIDLHDPA TNEVVTRVPK 

        70         80         90        100        110        120 
CTQDEMQTAV ESSKKAYKTW RQSSILSRQQ VMLKLQHIIR NNMSELAKNI TKEQGKTLID 

       130        140        150        160        170        180 
AEGDVLRGLQ VVEHCCSITS LQMGETVPNI AKDMDTYSYH LPLGVTAGIA PFNFPAMIPL 

       190        200        210        220        230        240 
WMFPVAITCG NTSIIKPSER VPGATMLLME MLNEAGCPPG VVNVIHGAHD AVNFVCDNPD 

       250        260        270        280        290        300 
IRAVSFVGSD QAGKYIYERA GRNGKRVQCN MGAKNHGVIM ADANKENTLN QLAGAAFGAA 

       310        320        330        340        350        360 
GQRCMALSTA VFVGEARNWI PDLVERARKL KVNAGHLPGT DLGPVISPQS KQRINELVES 

       370        380        390        400        410        420 
GAKEGAKIVL DGRNIKVEGF EKGNFVGPTI ISDVTPNMKC YTEEIFGPVL VCLSVDTIDE 

       430        440        450        460        470        480 
AIELINNNPY GNGTAIFTTN GATARKFVND IDVGQVGVNV PIPVPLPMFS FTGSRGSFLG 

       490        500        510        520 
DCHFYGKQGI KFYTQTKTVT QLWREGDVSH TKAAVAMPTM K

« Hide

References

[1]"The genome sequence of the malaria mosquito Anopheles gambiae."
Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F. expand/collapse author list , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
Science 298:129-149(2002) [PubMed: 12364791] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PEST.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AAAB01008859 Genomic DNA. Translation: EAA07972.4.
RefSeqXP_312441.4. XM_312441.5.

3D structure databases

ProteinModelPortalQ7QC84.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ7QC84.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaAGAP002499-RA; AGAP002499-PA; AGAP002499.
GeneID1273463.
KEGGaga:AgaP_AGAP002499.
VectorBaseAGAP002499. Anopheles gambiae.

Organism-specific databases

CTD1273463.

Phylogenomic databases

eggNOGinNOG06001.
GeneTreeEMGT00050000005689.
HOGENOMHBG752218.
InParanoidQ7QC84.
OMAIISNVKP.
OrthoDBEOG4N5TC3.
PhylomeDBQ7QC84.

Family and domain databases

InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010061. MeMal-semiAld_DH.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00140.
PANTHERPTHR11699:SF27. MMSDH. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01722. MMSDH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMMSA_ANOGA
AccessionPrimary (citable) accession number: Q7QC84
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 7, 2004
Last modified: December 14, 2011
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

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