Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kynurenine 3-monooxygenase

Gene

kh

Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.UniRule annotation

Catalytic activityi

L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Kynurenine 3-monooxygenase (kh)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

UniPathwayiUPA00253; UER00328.

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine 3-monooxygenaseUniRule annotation (EC:1.14.13.9UniRule annotation)
Alternative name(s):
Kynurenine 3-hydroxylaseUniRule annotation
Gene namesi
Name:kh
ORF Names:AGAP005948
OrganismiAnopheles gambiae (African malaria mosquito)
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
Proteomesi
  • UP000007062 Componenti: Chromosome 2L

Subcellular locationi

  • Mitochondrion UniRule annotation
  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei401 – 42424HelicalUniRule annotationAdd
BLAST
Transmembranei437 – 45923HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Kynurenine 3-monooxygenasePRO_0000361913Add
BLAST

Proteomic databases

PaxDbiQ7Q6A7.

Interactioni

Protein-protein interaction databases

STRINGi7165.AGAP005948-PA.

Structurei

3D structure databases

ProteinModelPortaliQ7Q6A7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2614. Eukaryota.
COG0654. LUCA.
HOGENOMiHOG000251788.
InParanoidiQ7Q6A7.
KOiK00486.
OMAiQPMISVK.
OrthoDBiEOG091G0769.
PhylomeDBiQ7Q6A7.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_01971. Kynurenine_monooxygenase. 1 hit.
InterProiIPR002938. FAD-bd.
IPR023753. FAD/NAD-binding_dom.
IPR027545. Kynurenine_monooxygenase.
[Graphical view]
PfamiPF01494. FAD_binding_3. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

Q7Q6A7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATASDSKYK RTNTNGMQHQ PLDVAIVGGG LVGSLLALHL GKKGHEVNLY
60 70 80 90 100
EYREDIRTAE LVIGRSINLA LSARGRRALA EVGLEDALLN HGIPMSGRML
110 120 130 140 150
HDVNGKCKIV PYDANTNQCI YSVGRKHLNE VLLNAAEKYP NIHLHFNHKL
160 170 180 190 200
VSANLDEGNL SMVDPVTKDV KSARADLIVG CDGAYSAVRK EIVKRPRYDF
210 220 230 240 250
SQTYIEHGYL ELCIPPTAGG EFAMPHNYLH IWPRGQFMMI ALPNQDRTWT
260 270 280 290 300
VTLFMPFTQF HSITDQGLLL DFFRQHFPDA IELIGRERLV KDFFKTKAQP
310 320 330 340 350
LVMIKCRPYH IGAKALIIGD AAHAMVPFYG QGMNAGFEDC SVLTELFNQY
360 370 380 390 400
GTDLARILPE FSEKRWEDAH AICDLAMYNY IEMRDLVTKR SYLLRKKLDE
410 420 430 440 450
LLFWMMPNTW VPLYNSVSFS HMRYSKCIAN RAWQDKILTR VLYGASIASV
460 470 480
AAIGGLCYRH VTMGHLERLS TRILSTFQLL KPKASV
Length:486
Mass (Da):55,010
Last modified:December 7, 2004 - v2
Checksum:i5A5F80A34C8FAB97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008960 Genomic DNA. Translation: EAA11712.2.
RefSeqiXP_315983.2. XM_315983.4.

Genome annotation databases

EnsemblMetazoaiAGAP005948-RA; AGAP005948-PA; AGAP005948.
GeneIDi1276617.
KEGGiaga:AgaP_AGAP005948.
VectorBaseiAGAP005948-RA; AGAP005948-PA; AGAP005948.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008960 Genomic DNA. Translation: EAA11712.2.
RefSeqiXP_315983.2. XM_315983.4.

3D structure databases

ProteinModelPortaliQ7Q6A7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7165.AGAP005948-PA.

Proteomic databases

PaxDbiQ7Q6A7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAGAP005948-RA; AGAP005948-PA; AGAP005948.
GeneIDi1276617.
KEGGiaga:AgaP_AGAP005948.
VectorBaseiAGAP005948-RA; AGAP005948-PA; AGAP005948.

Organism-specific databases

CTDi1276617.

Phylogenomic databases

eggNOGiKOG2614. Eukaryota.
COG0654. LUCA.
HOGENOMiHOG000251788.
InParanoidiQ7Q6A7.
KOiK00486.
OMAiQPMISVK.
OrthoDBiEOG091G0769.
PhylomeDBiQ7Q6A7.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00328.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_01971. Kynurenine_monooxygenase. 1 hit.
InterProiIPR002938. FAD-bd.
IPR023753. FAD/NAD-binding_dom.
IPR027545. Kynurenine_monooxygenase.
[Graphical view]
PfamiPF01494. FAD_binding_3. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiKMO_ANOGA
AccessioniPrimary (citable) accession number: Q7Q6A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: December 7, 2004
Last modified: September 7, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.