ID   Q7Q504_ANOGA            Unreviewed;      1259 AA.
AC   Q7Q504;
DT   15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 5.
DT   27-MAR-2024, entry version 140.
DE   SubName: Full=AGAP004656-PA {ECO:0000313|EMBL:EAA11974.5};
GN   ORFNames=AgaP_AGAP004656 {ECO:0000313|EMBL:EAA11974.5};
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA11974.5};
RN   [1] {ECO:0000313|EMBL:EAA11974.5}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA11974.5};
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
RN   [2] {ECO:0000313|EMBL:EAA11974.5}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA11974.5};
RG   The Anopheles Genome Sequencing Consortium;
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:EAA11974.5}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA11974.5};
RX   PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA   Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT   "The Anopheles gambiae genome: an update.";
RL   Trends Parasitol. 20:49-52(2004).
RN   [4] {ECO:0000313|EMBL:EAA11974.5}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA11974.5};
RX   PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA   Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA   Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT   "Update of the Anopheles gambiae PEST genome assembly.";
RL   Genome Biol. 8:R5.1-R5.13(2007).
RN   [5] {ECO:0000313|EMBL:EAA11974.5}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA11974.5};
RG   VectorBase;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAA11974.5}.
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DR   EMBL; AAAB01008961; EAA11974.5; -; Genomic_DNA.
DR   RefSeq; XP_316738.5; XM_316738.5.
DR   AlphaFoldDB; Q7Q504; -.
DR   STRING; 7165.Q7Q504; -.
DR   PaxDb; 7165-AGAP004656-PA; -.
DR   GeneID; 1277307; -.
DR   KEGG; aga:AgaP_AGAP004656; -.
DR   VEuPathDB; VectorBase:AGAP004656; -.
DR   eggNOG; KOG1081; Eukaryota.
DR   HOGENOM; CLU_004494_2_1_1; -.
DR   InParanoid; Q7Q504; -.
DR   OMA; DAGWPTY; -.
DR   OrthoDB; 950362at2759; -.
DR   PhylomeDB; Q7Q504; -.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046975; F:histone H3K36 methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR   CDD; cd15565; PHD2_NSD; 1.
DR   CDD; cd15566; PHD3_NSD; 1.
DR   CDD; cd15567; PHD4_NSD; 1.
DR   CDD; cd20144; PWWP_NSD_rpt1; 1.
DR   CDD; cd05838; PWWP_NSD_rpt2; 1.
DR   Gene3D; 2.30.30.140; -; 2.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR000313; PWWP_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR22884:SF413; HISTONE-LYSINE N-METHYLTRANSFERASE CG1716-RELATED; 1.
DR   PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1.
DR   Pfam; PF17907; AWS; 1.
DR   Pfam; PF00855; PWWP; 2.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00249; PHD; 4.
DR   SMART; SM00293; PWWP; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   SUPFAM; SSF63748; Tudor/PWWP/MBT; 2.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50812; PWWP; 2.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          264..312
FT                   /note="PWWP"
FT                   /evidence="ECO:0000259|PROSITE:PS50812"
FT   DOMAIN          831..893
FT                   /note="PWWP"
FT                   /evidence="ECO:0000259|PROSITE:PS50812"
FT   DOMAIN          970..1020
FT                   /note="AWS"
FT                   /evidence="ECO:0000259|PROSITE:PS51215"
FT   DOMAIN          1022..1139
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   DOMAIN          1146..1162
FT                   /note="Post-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50868"
FT   REGION          16..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          132..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          407..426
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          449..483
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        137..162
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1259 AA;  142173 MW;  AAEEBE4A3ABD50A0 CRC64;
     MFFAATAAAT NFETDLLSPT TTQKRVKSQE STPQSQKIAK QEPMSGSEMN ESGKENAFSD
     QIRNHPTDEN SNTVVRVPGR YLLKQLSSSL SPKMTEINID TDRRVSRYGR HQKQKDNSDY
     VPVDLMKYVG STPSKFKTKS ETDDPNSVNK TLETKPHSSD ELRTGSNDIS LSLTVVPLPL
     IDGSIMKRPE EKQLLSMEEI KIVGMEEPYY TDKGSDNNCF MNNLLERKTS SDADSGKGSS
     VDLAIIYRAG NLYWAAQTRK SIHWPCIVHV DPETDQITRL YGDKFLEVHV SYFGDRGRRA
     WIKEHSILPF EGVDEYCTNA KNMEYGKLLK SALKSERWKN ACSIAERYMT LALSERIASF
     DHEVKLELAR HKVMRHRMAI EGRIKNGASQ KMPALLPSDN SEVLEHWNKR DRSSSPESPE
     YELLPGVFPT KNNPIKKIKF SPSMQNCILN DNRSPLDRPL HSMDSEENPP GSATKANGPK
     AKTLGVSDLE NLNSTEYDDI LTFIRYYMFD GHTSYEVEKG LQLYVRGICN LKKHSNRGTE
     RTVGRQRMHA LRKSYEILGI EPSAEVSTSL KTRNAHPVIK KEPKTLEEKF IFELDKNFLM
     KGVPKGFVCY ICNRPNNVTK CSKCTLHLHL VCLANDPEEV VKMQELVDQK KLCCEKCSTT
     SIVEKTCFIC NDEIPEKSNE QIYRCVVGKC TQAYHISCLQ LFPQVRQVSA STIICPYHTC
     HTCVASEPRS TASMVKTTLA HCLKCPTSYH PSGNCIPAGS VLLTTTQLIC PKHTLEQIPL
     NVNWCFICGK GGNLICCETC PLACHPVCLQ FTPPDEKYFC EGCESGRLPL YNEIVIAKMG
     SFRWWPALTL PPSEIPQNML QLRHKPSDIC VKFFNTHDMS WLNRKRMYLY QREDSESLDG
     SQSGSSMDKR YRSAMTEASK IFKILQTRKM LGPSASLSYS KAVPVYKKIK TNRYIPPLKP
     PSVNRQLDGV EDSVCRCQPS DDDPCGPTSA CLNRAIMMEC SSKTCPAKES CSNQRFTKRI
     YPALEVRFFS DKGFGLVALE DLKSGQFVIE YVGEVINSEE FDRRVMMMQA AKETNYYFLT
     VEPDLTIDAG PKGNVSRFIN HSCEPNCETQ KWTIGETRVI GLFAIKDINA GEELTFNYNL
     ESLGNNKRVC LCGAGKCSGF IGEKYRPPNK KDIVISMKSE RSLKNGKKRV KIRRTKTTLT
     QKTTTNLSET KDTNNQLNDN DVVMISAQEA VIVDLVDENA SAYPLASVHI KQEKNDYNI
//