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Protein

Histone-lysine N-methyltransferase

Gene

AgaP_AGAP004656

Organism
Anopheles gambiae (African malaria mosquito)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionineSAAS annotation, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseSAAS annotation (EC:2.1.1.43SAAS annotation)
Gene namesi
ORF Names:AgaP_AGAP004656Imported
OrganismiAnopheles gambiae (African malaria mosquito)Imported
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
ProteomesiUP000007062 Componenti: Chromosome 2R

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi7165.AGAP004656-PA.

Family & Domainsi

Sequence similaritiesi

Contains 1 post-SET domain.UniRule annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000046762.
InParanoidiQ7Q504.
KOiK11424.
OrthoDBiEOG7B05CD.
PhylomeDBiQ7Q504.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR006560. AWS_dom.
IPR003616. Post-SET_dom.
IPR000313. PWWP_dom.
IPR001214. SET_dom.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00855. PWWP. 2 hits.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00249. PHD. 4 hits.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS50812. PWWP. 2 hits.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Q504-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFFAATAAAT NFETDLLSPT TTQKRVKSQE STPQSQKIAK QEPMSGSEMN
60 70 80 90 100
ESGKENAFSD QIRNHPTDEN SNTVVRVPGR YLLKQLSSSL SPKMTEINID
110 120 130 140 150
TDRRVSRYGR HQKQKDNSDY VPVDLMKYVG STPSKFKTKS ETDDPNSVNK
160 170 180 190 200
TLETKPHSSD ELRTGSNDIS LSLTVVPLPL IDGSIMKRPE EKQLLSMEEI
210 220 230 240 250
KIVGMEEPYY TDKGSDNNCF MNNLLERKTS SDADSGKGSS VDLAIIYRAG
260 270 280 290 300
NLYWAAQTRK SIHWPCIVHV DPETDQITRL YGDKFLEVHV SYFGDRGRRA
310 320 330 340 350
WIKEHSILPF EGVDEYCTNA KNMEYGKLLK SALKSERWKN ACSIAERYMT
360 370 380 390 400
LALSERIASF DHEVKLELAR HKVMRHRMAI EGRIKNGASQ KMPALLPSDN
410 420 430 440 450
SEVLEHWNKR DRSSSPESPE YELLPGVFPT KNNPIKKIKF SPSMQNCILN
460 470 480 490 500
DNRSPLDRPL HSMDSEENPP GSATKANGPK AKTLGVSDLE NLNSTEYDDI
510 520 530 540 550
LTFIRYYMFD GHTSYEVEKG LQLYVRGICN LKKHSNRGTE RTVGRQRMHA
560 570 580 590 600
LRKSYEILGI EPSAEVSTSL KTRNAHPVIK KEPKTLEEKF IFELDKNFLM
610 620 630 640 650
KGVPKGFVCY ICNRPNNVTK CSKCTLHLHL VCLANDPEEV VKMQELVDQK
660 670 680 690 700
KLCCEKCSTT SIVEKTCFIC NDEIPEKSNE QIYRCVVGKC TQAYHISCLQ
710 720 730 740 750
LFPQVRQVSA STIICPYHTC HTCVASEPRS TASMVKTTLA HCLKCPTSYH
760 770 780 790 800
PSGNCIPAGS VLLTTTQLIC PKHTLEQIPL NVNWCFICGK GGNLICCETC
810 820 830 840 850
PLACHPVCLQ FTPPDEKYFC EGCESGRLPL YNEIVIAKMG SFRWWPALTL
860 870 880 890 900
PPSEIPQNML QLRHKPSDIC VKFFNTHDMS WLNRKRMYLY QREDSESLDG
910 920 930 940 950
SQSGSSMDKR YRSAMTEASK IFKILQTRKM LGPSASLSYS KAVPVYKKIK
960 970 980 990 1000
TNRYIPPLKP PSVNRQLDGV EDSVCRCQPS DDDPCGPTSA CLNRAIMMEC
1010 1020 1030 1040 1050
SSKTCPAKES CSNQRFTKRI YPALEVRFFS DKGFGLVALE DLKSGQFVIE
1060 1070 1080 1090 1100
YVGEVINSEE FDRRVMMMQA AKETNYYFLT VEPDLTIDAG PKGNVSRFIN
1110 1120 1130 1140 1150
HSCEPNCETQ KWTIGETRVI GLFAIKDINA GEELTFNYNL ESLGNNKRVC
1160 1170 1180 1190 1200
LCGAGKCSGF IGEKYRPPNK KDIVISMKSE RSLKNGKKRV KIRRTKTTLT
1210 1220 1230 1240 1250
QKTTTNLSET KDTNNQLNDN DVVMISAQEA VIVDLVDENA SAYPLASVHI

KQEKNDYNI
Length:1,259
Mass (Da):142,173
Last modified:July 27, 2011 - v5
Checksum:iAAEEBE4A3ABD50A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008961 Genomic DNA. Translation: EAA11974.5.
RefSeqiXP_316738.5. XM_316738.5.

Genome annotation databases

EnsemblMetazoaiAGAP004656-RA; AGAP004656-PA; AGAP004656.
GeneIDi1277307.
KEGGiaga:AgaP_AGAP004656.
VectorBaseiAGAP004656. Anopheles gambiae.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008961 Genomic DNA. Translation: EAA11974.5.
RefSeqiXP_316738.5. XM_316738.5.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7165.AGAP004656-PA.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAGAP004656-RA; AGAP004656-PA; AGAP004656.
GeneIDi1277307.
KEGGiaga:AgaP_AGAP004656.
VectorBaseiAGAP004656. Anopheles gambiae.

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000046762.
InParanoidiQ7Q504.
KOiK11424.
OrthoDBiEOG7B05CD.
PhylomeDBiQ7Q504.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR006560. AWS_dom.
IPR003616. Post-SET_dom.
IPR000313. PWWP_dom.
IPR001214. SET_dom.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00855. PWWP. 2 hits.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00249. PHD. 4 hits.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS50812. PWWP. 2 hits.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of the malaria mosquito Anopheles gambiae."
    Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M., Wides R., Salzberg S.L., Loftus B., Yandell M., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F.
    , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C., Kokoza E., Koutsos A., Letunic I., Levitsky A., Liang Y., Lin J.J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z., Unger M.F., Walenz B., Wang A., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
    Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PESTImported.

Entry informationi

Entry nameiQ7Q504_ANOGA
AccessioniPrimary (citable) accession number: Q7Q504
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: July 27, 2011
Last modified: June 24, 2015
This is version 87 of the entry and version 5 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.