Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone-lysine N-methyltransferase

Gene

1277307

Organism
Anopheles gambiae (African malaria mosquito)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferaseSAAS annotation, Transferase
LigandMetal-binding, S-adenosyl-L-methionineSAAS annotation, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseSAAS annotation (EC:2.1.1.43SAAS annotation)
Gene namesi
Name:1277307Imported
ORF Names:AgaP_AGAP004656Imported
OrganismiAnopheles gambiae (African malaria mosquito)Imported
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
Proteomesi
  • UP000007062 Componenti: Chromosome 2R

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiQ7Q504.

Interactioni

Protein-protein interaction databases

STRINGi7165.AGAP004656-PA.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini264 – 312PWWPInterPro annotationAdd BLAST49
Domaini831 – 893PWWPInterPro annotationAdd BLAST63
Domaini970 – 1020AWSInterPro annotationAdd BLAST51
Domaini1022 – 1139SETInterPro annotationAdd BLAST118
Domaini1146 – 1162Post-SETInterPro annotationAdd BLAST17

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiKOG1081. Eukaryota.
COG2940. LUCA.
HOGENOMiHOG000046762.
InParanoidiQ7Q504.
KOiK11424.
OrthoDBiEOG091G02U7.
PhylomeDBiQ7Q504.

Family and domain databases

Gene3Di3.30.40.10. 3 hits.
InterProiView protein in InterPro
IPR006560. AWS_dom.
IPR003616. Post-SET_dom.
IPR000313. PWWP_dom.
IPR001214. SET_dom.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF00855. PWWP. 2 hits.
PF00856. SET. 1 hit.
SMARTiView protein in SMART
SM00570. AWS. 1 hit.
SM00249. PHD. 4 hits.
SM00293. PWWP. 1 hit.
SM00317. SET. 1 hit.
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiView protein in PROSITE
PS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS50812. PWWP. 2 hits.
PS50280. SET. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7Q504-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFFAATAAAT NFETDLLSPT TTQKRVKSQE STPQSQKIAK QEPMSGSEMN
60 70 80 90 100
ESGKENAFSD QIRNHPTDEN SNTVVRVPGR YLLKQLSSSL SPKMTEINID
110 120 130 140 150
TDRRVSRYGR HQKQKDNSDY VPVDLMKYVG STPSKFKTKS ETDDPNSVNK
160 170 180 190 200
TLETKPHSSD ELRTGSNDIS LSLTVVPLPL IDGSIMKRPE EKQLLSMEEI
210 220 230 240 250
KIVGMEEPYY TDKGSDNNCF MNNLLERKTS SDADSGKGSS VDLAIIYRAG
260 270 280 290 300
NLYWAAQTRK SIHWPCIVHV DPETDQITRL YGDKFLEVHV SYFGDRGRRA
310 320 330 340 350
WIKEHSILPF EGVDEYCTNA KNMEYGKLLK SALKSERWKN ACSIAERYMT
360 370 380 390 400
LALSERIASF DHEVKLELAR HKVMRHRMAI EGRIKNGASQ KMPALLPSDN
410 420 430 440 450
SEVLEHWNKR DRSSSPESPE YELLPGVFPT KNNPIKKIKF SPSMQNCILN
460 470 480 490 500
DNRSPLDRPL HSMDSEENPP GSATKANGPK AKTLGVSDLE NLNSTEYDDI
510 520 530 540 550
LTFIRYYMFD GHTSYEVEKG LQLYVRGICN LKKHSNRGTE RTVGRQRMHA
560 570 580 590 600
LRKSYEILGI EPSAEVSTSL KTRNAHPVIK KEPKTLEEKF IFELDKNFLM
610 620 630 640 650
KGVPKGFVCY ICNRPNNVTK CSKCTLHLHL VCLANDPEEV VKMQELVDQK
660 670 680 690 700
KLCCEKCSTT SIVEKTCFIC NDEIPEKSNE QIYRCVVGKC TQAYHISCLQ
710 720 730 740 750
LFPQVRQVSA STIICPYHTC HTCVASEPRS TASMVKTTLA HCLKCPTSYH
760 770 780 790 800
PSGNCIPAGS VLLTTTQLIC PKHTLEQIPL NVNWCFICGK GGNLICCETC
810 820 830 840 850
PLACHPVCLQ FTPPDEKYFC EGCESGRLPL YNEIVIAKMG SFRWWPALTL
860 870 880 890 900
PPSEIPQNML QLRHKPSDIC VKFFNTHDMS WLNRKRMYLY QREDSESLDG
910 920 930 940 950
SQSGSSMDKR YRSAMTEASK IFKILQTRKM LGPSASLSYS KAVPVYKKIK
960 970 980 990 1000
TNRYIPPLKP PSVNRQLDGV EDSVCRCQPS DDDPCGPTSA CLNRAIMMEC
1010 1020 1030 1040 1050
SSKTCPAKES CSNQRFTKRI YPALEVRFFS DKGFGLVALE DLKSGQFVIE
1060 1070 1080 1090 1100
YVGEVINSEE FDRRVMMMQA AKETNYYFLT VEPDLTIDAG PKGNVSRFIN
1110 1120 1130 1140 1150
HSCEPNCETQ KWTIGETRVI GLFAIKDINA GEELTFNYNL ESLGNNKRVC
1160 1170 1180 1190 1200
LCGAGKCSGF IGEKYRPPNK KDIVISMKSE RSLKNGKKRV KIRRTKTTLT
1210 1220 1230 1240 1250
QKTTTNLSET KDTNNQLNDN DVVMISAQEA VIVDLVDENA SAYPLASVHI

KQEKNDYNI
Length:1,259
Mass (Da):142,173
Last modified:July 27, 2011 - v5
Checksum:iAAEEBE4A3ABD50A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008961 Genomic DNA. Translation: EAA11974.5.
RefSeqiXP_316738.5. XM_316738.5.

Genome annotation databases

EnsemblMetazoaiAGAP004656-RA; AGAP004656-PA; AGAP004656.
GeneIDi1277307.
KEGGiaga:AgaP_AGAP004656.
VectorBaseiAGAP004656-RA; AGAP004656-PA; AGAP004656.

Similar proteinsi

Entry informationi

Entry nameiQ7Q504_ANOGA
AccessioniPrimary (citable) accession number: Q7Q504
Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: July 27, 2011
Last modified: August 30, 2017
This is version 108 of the entry and version 5 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported