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Q7Q2B0 (Q7Q2B0_ANOGA) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Proteasome subunit alpha type RuleBase RU000551
EC=3.4.25.1 RuleBase RU000551
Gene names
ORF Names:AGAP003935, AgaP_AGAP003935 EMBL EAA13600.2
OrganismAnopheles gambiae (African malaria mosquito)
Taxonomic identifier7165 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Anophelinae › Anopheles

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity. RuleBase RU000551

Catalytic activity

Cleavage of peptide bonds with very broad specificity. RuleBase RU000551

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits By similarity. RuleBase RU000551

Subcellular location

Cytoplasm. Nucleus By similarity RuleBase RU000551.

Sequence similarities

Belongs to the peptidase T1A family. RuleBase RU000551

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Sequences

Sequence LengthMass (Da)Tools
Q7Q2B0 [UniParc].

Last modified December 7, 2004. Version 2.
Checksum: EFC7409C42C9D9FD

FASTA24627,575
        10         20         30         40         50         60 
MSRGSSAGFD RHITIFSPEG RLYQVEYAFK AINQEGLTSI ALKGKDCAVV ATQKKIPDKL 

        70         80         90        100        110        120 
IDPATVTHLY RITREIGCVM TGRIADSRSQ VQRARYEAAN WRYKYGYEIP VDVLCRRMAD 

       130        140        150        160        170        180 
ISQVYTQNAE MRPLGCSIVM IAFDAENGPA VYKTDPAGYY CGYHAISVGV KQTEANSYLE 

       190        200        210        220        230        240 
KKLKRKAELS EEETIQLAIT CLSTVLAVDF KPTEIEIGIV SKEKPEFRTL TEDEIEVHLT 


AIAEKD

« Hide

References

[1]"The genome sequence of the malaria mosquito Anopheles gambiae."
Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F. expand/collapse author list , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
Science 298:129-149(2002) [PubMed: 12364791] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PEST.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AAAB01008978 Genomic DNA. Translation: EAA13600.2.
RefSeqXP_318387.2. XM_318387.4.

3D structure databases

ProteinModelPortalQ7Q2B0.
SMRQ7Q2B0. Positions 2-245.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ7Q2B0.

Protein family/group databases

MEROPST01.971.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaAGAP003935-RA; AGAP003935-PA; AGAP003935.
GeneID1278761.
KEGGaga:AgaP_AGAP003935.
VectorBaseAGAP003935. Anopheles gambiae.

Phylogenomic databases

eggNOGinNOG06332.
GeneTreeEMGT00050000009409.
HOGENOMHBG499923.
OMAGKDCAVV.
OrthoDBEOG4ZW3SZ.
PhylomeDBQ7Q2B0.

Family and domain databases

InterProIPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
KOK02730.
PfamPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
PROSITEPS00388. PROTEASOME_A_1. 1 hit.
PS51475. PROTEASOME_A_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ7Q2B0_ANOGA
AccessionPrimary (citable) accession number: Q7Q2B0
Entry history
Integrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: December 7, 2004
Last modified: January 25, 2012
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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