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Q7PTQ0

- Q7PTQ0_ANOGA

UniProt

Q7PTQ0 - Q7PTQ0_ANOGA

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Protein
Histone-lysine N-methyltransferase, H3 lysine-79 specific
Gene
AgaP_AGAP003282
Organism
Anopheles gambiae (African malaria mosquito)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferase
Gene namesi
ORF Names:AgaP_AGAP003282Imported
OrganismiAnopheles gambiae (African malaria mosquito)
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
ProteomesiUP000007062: Chromosome 2R

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7165.AGAP003282-PA.

Family & Domainsi

Sequence similaritiesi

Contains 1 DOT1 domain.UniRule annotation

Phylogenomic databases

eggNOGiNOG294902.
KOiK11427.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7PTQ0-1 [UniParc]FASTAAdd to Basket

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MATPNYKELK LQSPAGAEPF LYNFPFSTVM GTGHDSGAEL IENVRWVCED     50
MPEIKSAIEE IDLNNLDTNN YDAMKNLCDR FNRAIDSVAA LEKGTSLSNQ 100
RFTYPSRGLL KHILQQVYNQ AVVEPEKLNQ YEPFSPEVYG ETSFDLICQM 150
IDQVKITADD VFVDLGSGVG QVVLQMAAST PVKVCFGIEK ADVPSKYAEG 200
MNTTFKLWMR WFGKKYGDYE LIKGDFLADE YREKITSATI VFVNNFAFGP 250
NVDHQLKERF ADLRDGARIV SSKSFCPLNF RITDRNLSDI GTIMHVSEMS 300
PLRGSVSWTG KPVSYYLHII DRTKLERYFQ RLKTKGTENH TDGTSGGGSG 350
SHSTRSSRSR KDNNTNHHHH HPKVITNDDS TSESDTDVVG PTTRKAWSDW 400
NSGKEGKTSP SEEENNNSPV LRNGRIPVAT KKRRKITRTK AAGKKAELAA 450
ASAAAAAAAA AAAAAANRDM GVGTSAASAA AAAAAAMAGG KKRGRVKGKG 500
RQRRPLNIAG LDLLHNETLL STSEQMIGKR LPPAPGCVDQ QLTSLAGDMQ 550
HNELDIPEAP SETPYALQIL LDLYKTQFMK TIEAMRKPSY KDNVQQQFDR 600
EKERNQRLMN RAGQLEKQIK VLIDDSVALL KARMNELGIS TTSQNDLLCK 650
AKEIVGRHKE LQVMAAKLQN QVNVIEQEQK RLVMQHLTKL TVEQQQQHQQ 700
QQQHQQLHPH QPYIKQEDAE LTSSSSNELV LKAIASTLSQ RKKLYAQVSN 750
LETELNLIEK LTEERKSMVV GLSAAAPNSN HNSASSTAAA AAAAATSTII 800
SVARATEVRD REQYGHAGQL HPATIGGGRE REHIHPDGTT TSKHTSDPVR 850
TLPAGAAAGP VGVAGSAAPL PPPPMAGVGS ASVTVPSTPT KQGSGGGSSR 900
SAQRKSRENR TRSQEWPEIP DIGKIEENNP EILAQKILET GRQIEAGKLF 950
AAGKHASKER SSEGKLAPVV TAGHGSSAAA GTAAPQHIAH PPTVGAPAPQ 1000
QQPYPHHHQQ PHSQPSQPPV HPHLHHPDTA LMPAPASTIN KAHHHHRSNS 1050
GGPSGAVPPP VPTGGGSLPK CFVPGTASNE HHSGGGRNAP EGASGTGRGG 1100
GSGGGGGGGK LQDSHKVVNF EDRLKSIITS VLQGSPKTGN TASSASAPVS 1150
LTVTGPPPAG PSPGAGHRDA HHRSGSGGHQ PLTMEPAGSP LKATSASGAG 1200
YGSAAGPGKT TVYLQSSPGA GSHHPHQMVV AQDMSARSST GGRGPSPSAH 1250
NPAHQQQIHP HQVSQSQYQQ QQQLLHHPHH PHAQQSLHHQ QQQHQHYQMQ 1300
QQQQHQHQQQ QQGMLNVITS GAHHLNASTS ISTSPVPTSP YKMHPTGPPA 1350
SSIAGSASTK ISPSSKYPYP KGGPVAGMSH HSPGSSALST HQQIIQQQER 1400
ERAMLYAAAA HGGGLPIDHP HHPLHQHHHR GMPPSLVDGK MLEFKAPENF 1450
RYDPRASGPS GAAGNGPPML DTSAVSLQSH SRSSSTNSLD SIPAADYGPA 1500
SAGASAVGGG GARYGGQQQP IPLVTHSPGV GSQGSGQQHG GNNSRPGSTS 1550
SQPDYTQVSP AKMALRRHLS QEKLTHPSAG GPAAGGPVSG GTGAGGSGGG 1600
LGTVKTIGDL VNGEIERTLE ISNQSIINAA INMSSHQQQQ QSSAASGNSS 1650
APSASGNNTV INTHVQRPER VSIRLLEEAG HAAAGGPPPP GSSGGTYSPI 1700
SRPGSVGDSG SKSPVHHLHG QSNLASLVQV SAYNSKNHKG AGTTAVPSTI 1750
VSPRGGGSSQ QQQHQQYSTA QGSGAAGGPG AVYQQSTSRG HDRHHSGEPM 1800
PYMALPRADM KPYLESYFTD EHNKRQQQLH QQQQQHQQHP QHQQQHQQQH 1850
LQHPVQSPSP SAMSASAMGL HHHQQQQMHH QHAPLAMHRA SHPVDLHRGS 1900
VVMNEPGMLS RSRGEMIPMD DNRMDRLNGG PPLEGLAASL QARVIATLKI 1950
KEEDEERHRR DLSIHHSTSG TINSSSNSIN STNSNIHGGS LQIVQTAHIK 2000
SEKYTSSSSS SSTSSTSSTS SHHHHALKRT SPIVEHPAGT RPPKMLYTTS 2050
ASAGGMDCGP DADMLHVPRG TVPGSSVVGH SAVRGGLLVA PPLVMSPEIN 2100
SLSSVVDDGR HHHQLHVRHN HHSRNDVDEG TTATYYH 2137
Length:2,137
Mass (Da):227,396
Last modified:July 27, 2011 - v5
Checksum:i4B060F516452B213
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAAB01008794 Genomic DNA. Translation: EAA03558.6.
RefSeqiXP_307790.5. XM_307790.5.

Genome annotation databases

EnsemblMetazoaiAGAP003282-RA; AGAP003282-PA; AGAP003282.
GeneIDi1269184.
KEGGiaga:AgaP_AGAP003282.
VectorBaseiAGAP003282. Anopheles gambiae.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAAB01008794 Genomic DNA. Translation: EAA03558.6 .
RefSeqi XP_307790.5. XM_307790.5.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7165.AGAP003282-PA.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai AGAP003282-RA ; AGAP003282-PA ; AGAP003282 .
GeneIDi 1269184.
KEGGi aga:AgaP_AGAP003282.
VectorBasei AGAP003282. Anopheles gambiae.

Phylogenomic databases

eggNOGi NOG294902.
KOi K11427.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the malaria mosquito Anopheles gambiae."
    Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F.
    , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
    Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PESTImported.

Entry informationi

Entry nameiQ7PTQ0_ANOGA
AccessioniPrimary (citable) accession number: Q7PTQ0
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 64 of the entry and version 5 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi