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Protein

Serine--pyruvate aminotransferase

Gene

1272658

Organism
Anopheles gambiae (African malaria mosquito)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-alanine + glyoxylate = pyruvate + glycine.UniRule annotation
L-serine + pyruvate = 3-hydroxypyruvate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandPyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Serine--pyruvate aminotransferaseUniRule annotation (EC:2.6.1.44UniRule annotation, EC:2.6.1.51UniRule annotation)
Alternative name(s):
Alanine--glyoxylate aminotransferaseUniRule annotation
Gene namesi
Name:1272658Imported
Synonyms:3hktImported
ORF Names:AgaP_AGAP010387Imported
OrganismiAnopheles gambiae (African malaria mosquito)Imported
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
Proteomesi
  • UP000007062 Componenti: Chromosome 3L

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei205N6-(pyridoxal phosphate)lysineUniRule annotationCombined sources1

Interactioni

Protein-protein interaction databases

DIPiDIP-61154N
STRINGi7165.AGAP010387-PA

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CH1X-ray2.40A/B/C/D1-396[»]
2CH2X-ray2.70A/B/C/D1-396[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 346Aminotran_5InterPro annotationAdd BLAST325

Sequence similaritiesi

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2862 Eukaryota
COG0075 LUCA
HOGENOMiHOG000171815
KOiK00830
OMAiFGFVHAE
OrthoDBiEOG091G0EMK

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR020578 Aminotrans_V_PyrdxlP_BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR024169 SP_NH2Trfase/AEP_transaminase
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PIRSFiPIRSF000524 SPT, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00595 AA_TRANSFER_CLASS_5, 1 hit

Sequencei

Sequence statusi: Complete.

Q7PRG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFTPPPASL RNPLIIPEKI MMGPGPSNCS KRVLTAMTNT VLSNFHAELF
60 70 80 90 100
RTMDEVKDGL RYIFQTENRA TMCVSGSAHA GMEAMLSNLL EEGDRVLIAV
110 120 130 140 150
NGIWAERAVE MSERYGADVR TIEGPPDRPF SLETLARAIE LHQPKCLFLT
160 170 180 190 200
HGDSSSGLLQ PLEGVGQICH QHDCLLIVDA VASLCGVPFY MDKWEIDAVY
210 220 230 240 250
TGAQKVLGAP PGITPISISP KALDVIRNRR TKSKVFYWDL LLLGNYWGCY
260 270 280 290 300
DEPKRYHHTV ASNLIFALRE ALAQIAEEGL ENQIKRRIEC AQILYEGLGK
310 320 330 340 350
MGLDIFVKDP RHRLPTVTGI MIPKGVDWWK VSQYAMNNFS LEVQGGLGPT
360 370 380 390
FGKAWRVGIM GECSTVQKIQ FYLYGFKESL KATHPDYIFE ESNGFH
Length:396
Mass (Da):44,298
Last modified:January 9, 2007 - v3
Checksum:iF323DC64448CFEDC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei396Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM042695 mRNA Translation: CAJ14970.1
AAAB01008849 Genomic DNA Translation: EAA07245.4
RefSeqiXP_311559.3, XM_311559.4

Genome annotation databases

EnsemblMetazoaiAGAP010387-RA; AGAP010387-PA; AGAP010387
AGAP010387-RB; AGAP010387-PB; AGAP010387
GeneIDi1272658
KEGGiaga:AgaP_AGAP010387
VectorBaseiAGAP010387-RA; AGAP010387-PA; AGAP010387
AGAP010387-RB; AGAP010387-PB; AGAP010387

Similar proteinsi

Entry informationi

Entry nameiQ7PRG3_ANOGA
AccessioniPrimary (citable) accession number: Q7PRG3
Secondary accession number(s): Q4LAM2
Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

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