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Protein

Serine--pyruvate aminotransferase

Gene

3hkt

Organism
Anopheles gambiae (African malaria mosquito)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-alanine + glyoxylate = pyruvate + glycine.UniRule annotation
L-serine + pyruvate = 3-hydroxypyruvate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Serine--pyruvate aminotransferaseUniRule annotation (EC:2.6.1.44UniRule annotation, EC:2.6.1.51UniRule annotation)
Alternative name(s):
Alanine--glyoxylate aminotransferaseUniRule annotation
Gene namesi
Name:3hktImported
ORF Names:AgaP_AGAP010387Imported
OrganismiAnopheles gambiae (African malaria mosquito)Imported
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
Proteomesi
  • UP000007062 Componenti: Chromosome 3L

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei205 – 2051N6-(pyridoxal phosphate)lysineUniRule annotationCombined sources

Interactioni

Protein-protein interaction databases

DIPiDIP-61154N.
STRINGi7165.AGAP010387-PA.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CH1X-ray2.40A/B/C/D1-396[»]
2CH2X-ray2.70A/B/C/D1-396[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 346325Aminotran_5InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2862. Eukaryota.
COG0075. LUCA.
HOGENOMiHOG000171815.
KOiK00830.
OMAiMAGREME.
OrthoDBiEOG7CZK6B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000192. Aminotrans_V_dom.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR024169. SP_NH2Trfase/AEP_transaminase.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF000524. SPT. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00595. AA_TRANSFER_CLASS_5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7PRG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFTPPPASL RNPLIIPEKI MMGPGPSNCS KRVLTAMTNT VLSNFHAELF
60 70 80 90 100
RTMDEVKDGL RYIFQTENRA TMCVSGSAHA GMEAMLSNLL EEGDRVLIAV
110 120 130 140 150
NGIWAERAVE MSERYGADVR TIEGPPDRPF SLETLARAIE LHQPKCLFLT
160 170 180 190 200
HGDSSSGLLQ PLEGVGQICH QHDCLLIVDA VASLCGVPFY MDKWEIDAVY
210 220 230 240 250
TGAQKVLGAP PGITPISISP KALDVIRNRR TKSKVFYWDL LLLGNYWGCY
260 270 280 290 300
DEPKRYHHTV ASNLIFALRE ALAQIAEEGL ENQIKRRIEC AQILYEGLGK
310 320 330 340 350
MGLDIFVKDP RHRLPTVTGI MIPKGVDWWK VSQYAMNNFS LEVQGGLGPT
360 370 380 390
FGKAWRVGIM GECSTVQKIQ FYLYGFKESL KATHPDYIFE ESNGFH
Length:396
Mass (Da):44,298
Last modified:January 9, 2007 - v3
Checksum:iF323DC64448CFEDC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei396 – 3961Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM042695 mRNA. Translation: CAJ14970.1.
AAAB01008849 Genomic DNA. Translation: EAA07245.4.
RefSeqiXP_311559.3. XM_311559.4.

Genome annotation databases

EnsemblMetazoaiAGAP010387-RA; AGAP010387-PA; AGAP010387.
AGAP010387-RB; AGAP010387-PB; AGAP010387.
GeneIDi1272658.
KEGGiaga:AgaP_AGAP010387.
VectorBaseiAGAP010387. Anopheles gambiae.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM042695 mRNA. Translation: CAJ14970.1.
AAAB01008849 Genomic DNA. Translation: EAA07245.4.
RefSeqiXP_311559.3. XM_311559.4.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CH1X-ray2.40A/B/C/D1-396[»]
2CH2X-ray2.70A/B/C/D1-396[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61154N.
STRINGi7165.AGAP010387-PA.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAGAP010387-RA; AGAP010387-PA; AGAP010387.
AGAP010387-RB; AGAP010387-PB; AGAP010387.
GeneIDi1272658.
KEGGiaga:AgaP_AGAP010387.
VectorBaseiAGAP010387. Anopheles gambiae.

Phylogenomic databases

eggNOGiKOG2862. Eukaryota.
COG0075. LUCA.
HOGENOMiHOG000171815.
KOiK00830.
OMAiMAGREME.
OrthoDBiEOG7CZK6B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000192. Aminotrans_V_dom.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR024169. SP_NH2Trfase/AEP_transaminase.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF000524. SPT. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00595. AA_TRANSFER_CLASS_5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of the malaria mosquito Anopheles gambiae."
    Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F.
    , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
    Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PESTImported.
  2. Barcaccia G.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PESTImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PESTImported.
  4. "Identification and biochemical characterization of the Anopheles gambiae 3-hydroxykynurenine transaminase."
    Rossi F., Lombardo F., Paglino A., Cassani C., Miglio G., Arca B., Rizzi M.
    FEBS J. 272:5653-5662(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  5. "Crystal structure of the Anopheles gambiae 3-hydroxykynurenine transaminase."
    Rossi F., Garavaglia S., Giovenzana G.B., Arca B., Li J., Rizzi M.
    Proc. Natl. Acad. Sci. U.S.A. 103:5711-5716(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS), PYRIDOXAL PHOSPHATE AT LYS-205.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PESTImported.
  7. Qi P., Wei Y., Zheng Y.
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PESTImported.

Entry informationi

Entry nameiQ7PRG3_ANOGA
AccessioniPrimary (citable) accession number: Q7PRG3
Secondary accession number(s): Q4LAM2
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: January 9, 2007
Last modified: July 6, 2016
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.