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Q7PQM3 (Q7PQM3_ANOGA) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating RuleBase RU000485 PIRNR PIRNR000109
EC=1.1.1.44 RuleBase RU000485 PIRNR PIRNR000109
Gene names
ORF Names:AGAP004197, AgaP_AGAP004197 EMBL EAA08614.5
OrganismAnopheles gambiae (African malaria mosquito)
Taxonomic identifier7165 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Anophelinae › Anopheles

Protein attributes

Sequence length482 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. RuleBase RU000485 PIRNR PIRNR000109

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. RuleBase RU004281 PIRNR PIRNR000109

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. RuleBase RU000485 PIRNR PIRNR000109

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding12 – 176NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding35 – 373NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding77 – 793NADP By similarity PIRSR PIRSR000109-3
Region131 – 1333Substrate binding By similarity PIRSR PIRSR000109-2
Region188 – 1892Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1851Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1921Proton donor By similarity PIRSR PIRSR000109-1
Binding site1051NADP By similarity PIRSR PIRSR000109-3
Binding site1051Substrate By similarity PIRSR PIRSR000109-2
Binding site1931Substrate By similarity PIRSR PIRSR000109-2
Binding site2601Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2871Substrate By similarity PIRSR PIRSR000109-2
Binding site4461Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4521Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
Q7PQM3 [UniParc].

Last modified October 23, 2007. Version 4.
Checksum: 9324A0B217D5DC2E

FASTA48253,142
        10         20         30         40         50         60 
MSSPKADIAL IGLAVMGQNL ILNMDSKGFV VCAYNRTVDK VTHFLENEAK GTNIIGATSL 

        70         80         90        100        110        120 
QDMVNKLKKP RKIMMLVKAG SAVDDFINQL LPLIEKGDVI IDGGNSEHQD SARRYEELKA 

       130        140        150        160        170        180 
KGILYVGSGV SGGEEGARYG PSLMPGGHPD AWPLIKDIFQ AICAKSNGDP CCEWVGEGGA 

       190        200        210        220        230        240 
GHFVKMVHNG IEYGDMQLIC EAYHLMLALG MTQKEMAQEF DEWNKGVLDS FLIEITRDIL 

       250        260        270        280        290        300 
NYRDDEGYLL ERIRDTAGQK GTGKWTAIAA LHHGVPVTLI GEAVFSRCLS ALKEERARAS 

       310        320        330        340        350        360 
KQLAGPSTKA SVADRKQFLT HIRNALYCAK IVSYAQGFML LREAANEYKW NLNYGGIALM 

       370        380        390        400        410        420 
WRGGCIIRSV FLGNIRDAFV RNPQLSNLLL DDFFKKAMMD NQQSWREVVS QAVLWGVPVP 

       430        440        450        460        470        480 
ALSAALAFFD GYRSERLPAN LLQAQRDYFG AHTYELLGKE GKFVHTNWTG KGGNVSASTY 


LA

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References

[1]"The genome sequence of the malaria mosquito Anopheles gambiae."
Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F. expand/collapse author list , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
Science 298:129-149(2002) [PubMed: 12364791] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PEST.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AAAB01008880 Genomic DNA. Translation: EAA08614.5.
RefSeqXP_313091.4. XM_313091.5.

3D structure databases

ProteinModelPortalQ7PQM3.
SMRQ7PQM3. Positions 5-473.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ7PQM3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaAGAP004197-RA; AGAP004197-PA; AGAP004197.
GeneID1274031.
KEGGaga:AgaP_AGAP004197.
VectorBaseAGAP004197. Anopheles gambiae.

Phylogenomic databases

eggNOGinNOG06440.
GeneTreeEMGT00050000006696.
HOGENOMHBG286913.
OMASNYPDTN.
OrthoDBEOG4SN040.
PhylomeDBQ7PQM3.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ7PQM3_ANOGA
AccessionPrimary (citable) accession number: Q7PQM3
Entry history
Integrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: October 23, 2007
Last modified: December 14, 2011
This is version 71 of the entry and version 4 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info