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Reviewed, UniProtKB/Swiss-Prot Q7PPA5 (ATC1_ANOGA)

Last modified February 9, 2010. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type
    EC=3.6.3.8
Alternative name(s):
    Calcium pump
Gene names
Name: Ca-P60A
ORF Names: AGAP006186
OrganismAnopheles gambiae (African malaria mosquito) [Complete proteome]
Taxonomic identifier7165 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Anophelinae › Anopheles

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Protein attributes

Sequence length1018 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.

Catalytic activity

ATP + H2O + Ca2+(Cis) = ADP + phosphate + Ca2+(Trans).

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cation transport ATPase (P-type) family.

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Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform C (identifier: Q7PPA5-1)

Also known as: E; D;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform A (identifier: Q7PPA5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     993-1018: GESYIKNMHGLVLAWAVFFAYIIWGP → VNPDFH
Note: No experimental confirmation available.
Isoform B (identifier: Q7PPA5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     993-1018: GESYIKNMHGLVLAWAVFFAYIIWGP → ANEVIKTWE
Note: No experimental confirmation available.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10181018Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type
PRO_0000233305

Regions

Topological domain1 – 4848Cytoplasmic By similarity UniProtKB P04191
Transmembrane49 – 69211 By similarity UniProtKB P04191
Topological domain70 – 8819Lumenal By similarity UniProtKB P04191
Transmembrane89 – 109212 By similarity UniProtKB P04191
Topological domain110 – 252143Cytoplasmic By similarity UniProtKB P04191
Transmembrane253 – 272203 By similarity UniProtKB P04191
Topological domain273 – 29422Lumenal By similarity UniProtKB P04191
Transmembrane295 – 312184 By similarity UniProtKB P04191
Topological domain313 – 756444Cytoplasmic By similarity UniProtKB P04191
Transmembrane757 – 776205 By similarity UniProtKB P04191
Topological domain777 – 78610Lumenal By similarity UniProtKB P04191
Transmembrane787 – 807216 By similarity UniProtKB P04191
Topological domain808 – 82720Cytoplasmic By similarity UniProtKB P04191
Transmembrane828 – 850237 By similarity UniProtKB P04191
Topological domain851 – 89646Lumenal By similarity UniProtKB P04191
Transmembrane897 – 916208 By similarity UniProtKB P04191
Topological domain917 – 92913Cytoplasmic By similarity UniProtKB P04191
Transmembrane930 – 948199 By similarity UniProtKB P04191
Topological domain949 – 96315Lumenal By similarity UniProtKB P04191
Transmembrane964 – 9842110 By similarity UniProtKB P04191
Topological domain985 – 101834Cytoplasmic By similarity UniProtKB P04191

Sites

Active site35014-aspartylphosphate intermediate By similarity UniProtKB P04191
Metal binding3031Calcium 2; via carbonyl oxygen By similarity UniProtKB P04191
Metal binding3041Calcium 2; via carbonyl oxygen By similarity UniProtKB P04191
Metal binding3061Calcium 2; via carbonyl oxygen By similarity UniProtKB P04191
Metal binding3081Calcium 2 By similarity UniProtKB P04191
Metal binding7021Magnesium By similarity UniProtKB P04191
Metal binding7061Magnesium By similarity UniProtKB P04191
Metal binding7671Calcium 1 By similarity UniProtKB P04191
Metal binding7701Calcium 1 By similarity UniProtKB P04191
Metal binding7951Calcium 2 By similarity UniProtKB P04191
Metal binding7981Calcium 1 By similarity UniProtKB P04191
Metal binding7991Calcium 1 By similarity UniProtKB P04191
Metal binding7991Calcium 2 By similarity UniProtKB P04191
Metal binding9071Calcium 1 By similarity UniProtKB P04191

Natural variations

Alternative sequence993 – 101826GESYI…IIWGP → VNPDFH in isoform A.
VSP_030291
Alternative sequence993 – 101826GESYI…IIWGP → ANEVIKTWE in isoform B.
VSP_030292

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Sequences

Sequence LengthMass (Da)Tools
Isoform C (E) (D) [UniParc].

Last modified January 15, 2008. Version 5.
Checksum: 4682B896CC48E90E

FASTA1,018111,859
        10         20         30         40         50         60 
MEDGHSKTVD EVLSHFRVDP ERGLSLDQVK EYQKKYGPNE LPAEEGKTLW QLVLEQFDDL 

        70         80         90        100        110        120 
LVKILLLAAI ISFVLALFEE HEGVEAFVEP FVILLILIAN AVVGVWQERN AESAIEALKE 

       130        140        150        160        170        180 
YEPEMGKVIR GDKSGVQKIR AKEIVPGDVV EVSVGDKIPA DIRLIKIYST TIRIDQSILT 

       190        200        210        220        230        240 
GESVSVIKHT DAVPDPRAVN QDKKNILFSG TNVAAGKARG VVIGTGLNTA IGKIRTEMSE 

       250        260        270        280        290        300 
TEEIKTPLQQ KLDEFGEQLS KVISLICVAV WAINIGHFND PAHGGSWIKG AVYYFKIAVA 

       310        320        330        340        350        360 
LAVAAIPEGL PAVITTCLAL GTRRMAKKNA IVRSLPSVET LGCTSVICSD KTGTLTTNQM 

       370        380        390        400        410        420 
SVSRMFIFEK IEGNDSSFTE FEISGSTYEP IGEVTLNGQR IKAADYETLH ELGTICIMCN 

       430        440        450        460        470        480 
DSAIDFNETK KVFEKVGEAT ETALIVLAEK LNPFNVAKQG LDRRSSAICV RQEIETKWKK 

       490        500        510        520        530        540 
EFTLEFSRDR KSMSSYCTPL KASKLGNGPK LFCKGAPEGV LERCTHARVG STKVPLTQTL 

       550        560        570        580        590        600 
KQRILDLTRT YGTGRDTLRC LALATADSPM KPDDMDLNDS TKFYTYEVNL TFVGVVGMLD 

       610        620        630        640        650        660 
PPRKEVQDSI VRCRAAGIRV IVITGDNKAT AEAICRRIGV FGEDEDTTGK SYSGREFDDL 

       670        680        690        700        710        720 
SVSEQREACS RARLFSRVEP AHKSKIVEFL QSMNEISAMT GDGVNDAPAL KKAEIGIAMG 

       730        740        750        760        770        780 
SGTAVAKSAA EMVLADDNFS SIVAAVEEGR AIYNNMKQFI RYLISSNIGE VVSIFLTAAL 

       790        800        810        820        830        840 
GLPEALIPVQ LLWVNLVTDG LPATALGFNP PDLDIMTKPP RKADEGLISG WLFFRYMAIG 

       850        860        870        880        890        900 
GYVGCATVGG AAWWFMFSET GPQLSYWQLT HHLSCLGGGE EFKGIDCKIF NDPHPMTMAL 

       910        920        930        940        950        960 
SVLVTIEMLN AMNSLSENQS LVQMPPWCNI WLIASMCLSF ALHFVILYVD VLSTVFQVTP 

       970        980        990       1000       1010 
LDGNEWMTVM KFSLPVVLLD EILKFVARRI SDGESYIKNM HGLVLAWAVF FAYIIWGP

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Isoform A.

Checksum: CA1A2DEE54E434C2
Show »

FASTA998109,603
Isoform B.

Checksum: FD631668C3A59224
Show »

FASTA1,001109,965

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References

[1]"The genome sequence of the malaria mosquito Anopheles gambiae."
Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F. expand/collapse author list , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
Science 298:129-149(2002) [PubMed: 12364791] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PEST.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AAAB01008960 Genomic DNA. Translation: EAA10790.5.
AAAB01008960 Genomic DNA. Translation: EDO63821.1.
AAAB01008960 Genomic DNA. Translation: EDO63822.1.
AAAB01008960 Genomic DNA. Translation: EDO63823.1.
AAAB01008960 Genomic DNA. Translation: EDO63824.1.
RefSeqXP_001688815.1.
XP_001688816.1.
XP_001688817.1.
XP_001688818.1.
XP_316251.4.

3D structure databases

SMRQ7PPA5. Positions 1-988.
ModBaseSearch...

Genome annotation databases

GeneID1276852.
KEGGaga:AgaP_AGAP006186.
VectorBaseAGAP006186. Anopheles gambiae.

Phylogenomic databases

eggNOGinNOG09096.
HOGENOMHBG456486.
InParanoidQ7PPA5.
OMAQVKRNLE.
OrthoDBEOG9R241C.
PhylomeDBQ7PPA5.

Enzyme and pathway databases

BRENDA3.6.3.8. 165157.

Family and domain databases

InterProIPR008250. ATPase_P-typ_ATPase-assoc-dom.
IPR005782. ATPase_P-typ_Ca-transp.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR005834. Dehalogen-like_hydro.
[Graphical view]
PANTHERPTHR11939. ATPase_P. 1 hit.
PfamPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
SMARTSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01116. ATPase-IIA1_Ca. 1 hit.
TIGR01494. ATPase_P-type. 4 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameATC1_ANOGA
AccessionPrimary (citable) accession number: Q7PPA5
Secondary accession number(s): A7UU43, A7UU44, A7UU45
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: January 15, 2008
Last modified: February 9, 2010
This is version 59 of the entry and version 5 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents