Q7PND3 (UFC1_ANOGA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin-fold modifier-conjugating enzyme 1

Alternative name(s):
Ufm1-conjugating enzyme 1

Gene names

ORF Names:

AGAP008099

Organism

Anopheles gambiae (African malaria mosquito) [Reference proteome]

Taxonomic identifier

7165 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicimorpha › Culicoidea › Culicidae › Anophelinae › Anopheles › Cellia › Pyretophorus › gambiae species complex

Protein attributes

Sequence length	167 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage By similarity.
Sequence similarities	Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 167	167	Ubiquitin-fold modifier-conjugating enzyme 1		PRO_0000391965
Sites
	Active site	116	1	Glycyl thioester intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7PND3 [UniParc]. Last modified January 9, 2007. Version 3. Checksum: 007F5BD5DB164CF5	FASTA	167	19,174
	10 20 30 40 50 60 MVDDGTRKAL SGIPLLKTKA GPRDKELWVQ RLKEEYQALI KYVQNNKASD MDWFRLESNK 70 80 90 100 110 120 EGTKWFGKCW YMYNLHKYEF DVEFDIPITY PTTSPEIALP ELDGKTAKMY RGGKICLTDH 130 140 150 160 FKPLWARNVP KFGIAHAMAL GLAPWLAVEV PDLIEKGVIS YQEKGSS

References

[1]

"The genome sequence of the malaria mosquito Anopheles gambiae." Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F. , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L. Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PEST.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAAB01008964 Genomic DNA. Translation: EAA12363.4.
RefSeq	XP_317357.3. XM_317357.3.
3D structure databases
ProteinModelPortal	Q7PND3.
SMR	Q7PND3. Positions 1-164.
ModBase	Search...
Protein-protein interaction databases
STRING	7165.AGAP008099-PA.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	AGAP008099-RA; AGAP008099-PA; AGAP008099.
GeneID	1277852.
KEGG	aga:AgaP_AGAP008099.
VectorBase	AGAP008099. Anopheles gambiae.
Organism-specific databases
CTD	1277852.
Phylogenomic databases
eggNOG	NOG318908.
HOGENOM	HOG000243361.
KO	K12165.
OMA	GTKWFGK.
OrthoDB	EOG4V6WZV.
PhylomeDB	Q7PND3.
Family and domain databases
InterPro	IPR016135. UBQ-conjugating_enzyme/RWD. IPR014806. Ufc1. [Graphical view]
PANTHER	PTHR12921. PTHR12921. 1 hit.
Pfam	PF08694. UFC1. 1 hit. [Graphical view]
PIRSF	PIRSF008716. DUF1782. 1 hit.
SUPFAM	SSF54495. UBQ-conjugat/RWD-like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UFC1_ANOGA

Accession

Primary (citable) accession number: Q7PND3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 2, 2010
Last sequence update:	January 9, 2007
Last modified:	April 3, 2013
This is version 59 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)