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Reviewed, UniProtKB/Swiss-Prot Q7P1G2 (GLPK_CHRVO)

Last modified June 16, 2009. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glycerol kinase
    EC=2.7.1.30
Alternative name(s):
    ATP:glycerol 3-phosphotransferase
    Glycerokinase
      Short name=GK
Gene names
Name: glpK
Ordered Locus Names: CV_0251
OrganismChromobacterium violaceum [Complete proteome] [HAMAP]
Taxonomic identifier536 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Chromobacterium

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Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500Glycerol kinase HAMAP MF_00186
PRO_0000059442

Regions

Nucleotide binding410 – 4145ATP By similarity

Sites

Binding site131Substrate By similarity
Binding site171ATP By similarity
Binding site831Substrate By similarity
Binding site1351Substrate By similarity
Binding site2441Substrate By similarity
Binding site2661ATP By similarity
Binding site3091ATP; via carbonyl oxygen By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q7P1G2-1 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 204AB6A8CC486FCC

FASTA50054,047
        10         20         30         40         50         60 
MTDQYVLALD QGTTSSRAIL FNRSGDIVSL AQKEFRQIYP QPGWVEHDPQ EIWGGQVGVA 

        70         80         90        100        110        120 
AEAVAKAGID GRSIAAIGIT NQRETTIVWD RETGQPVYNA IVWQDRRTAE FCDELKARGL 

       130        140        150        160        170        180 
GELIRSKTGL LVDAYFSGSK IKWILDNVPG ARDRAREGKL AFGTVDSWLI WNFTHGKVHV 

       190        200        210        220        230        240 
TDVSNASRTM LYNIHTLQWD AELLDIMGIP ASMLPEVKSS SEVYGHTHAA HLGVEIPIAG 

       250        260        270        280        290        300 
VAGDQQAALF GQQCTTPGMV KNTYGTGCFM MLNTGDKPIE SSNNLLTTIA WKVDGKVQYA 

       310        320        330        340        350        360 
LEGSIFIGGA VVKWLRDGLG IIRHSADVGP LAQEVKNSDG VYLVPAFAGL GAPHWNASAR 

       370        380        390        400        410        420 
GTIVGATLGT KAAHIARAAL DSIAYQTRDV LKAMEADAGM SIAELRVDGG ATVNELLMQF 

       430        440        450        460        470        480 
QSDILAVDVV RPKITETTAL GAAYLAGLAV GYWKSVDDIQ GQWQLDRRFQ PAMAADEVLA 

       490        500 
NVKGWQRAVN AAKVWADDQA

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References

[1]"The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability."
Vasconcelos A.T.R., de Almeida D.F., Hungria M., Guimaraes C.T., Antonio R.V., Almeida F.C., de Almeida L.G.P., de Almeida R., Alves-Gomes J.A., Andrade E.M., Araripe J., de Araujo M.F.F., Astolfi-Filho S., Azevedo V., Baptista A.J., Bataus L.A.M., Batista J.S., Belo A. expand/collapse author list , van den Berg C., Bogo M., Bonatto S., Bordignon J., Brigido M.M., Brito C.A., Brocchi M., Burity H.A., Camargo A.A., Cardoso D.D.P., Carneiro N.P., Carraro D.M., Carvalho C.M.B., Cascardo J.C.M., Cavada B.S., Chueire L.M.O., Creczynski-Pasa T.B., Cunha-Junior N.C., Fagundes N., Falcao C.L., Fantinatti F., Farias I.P., Felipe M.S.S., Ferrari L.P., Ferro J.A., Ferro M.I.T., Franco G.R., Freitas N.S.A., Furlan L.R., Gazzinelli R.T., Gomes E.A., Goncalves P.R., Grangeiro T.B., Grattapaglia D., Grisard E.C., Hanna E.S., Jardim S.N., Laurino J., Leoi L.C.T., Lima L.F.A., Loureiro M.F., Lyra M.C.C.P., Madeira H.M.F., Manfio G.P., Maranhao A.Q., Martins W.S., di Mauro S.M.Z., de Medeiros S.R.B., Meissner R.V., Moreira M.A.M., Nascimento F.F., Nicolas M.F., Oliveira J.G., Oliveira S.C., Paixao R.F.C., Parente J.A., Pedrosa F.O., Pena S.D.J., Pereira J.O., Pereira M., Pinto L.S.R.C., Pinto L.S., Porto J.I.R., Potrich D.P., Ramalho-Neto C.E., Reis A.M.M., Rigo L.U., Rondinelli E., Santos E.B.P., Santos F.R., Schneider M.P.C., Seuanez H.N., Silva A.M.R., da Silva A.L.C., Silva D.W., Silva R., Simoes I.C., Simon D., Soares C.M.A., Soares R.B.A., Souza E.M., Souza K.R.L., Souza R.C., Steffens M.B.R., Steindel M., Teixeira S.R., Urmenyi T., Vettore A., Wassem R., Zaha A., Simpson A.J.G.
Proc. Natl. Acad. Sci. U.S.A. 100:11660-11665(2003) [PubMed: 14500782] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 12472 / DSM 30191 / IFO 12614 / JCM 1249 / NCIB 9131.

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Cross-references

Sequence databases

AE016825 Genomic DNA. Translation: AAQ57930.1.
RefSeqNP_899921.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID2550563.
GenomeReviewsGene locus CV_0251 in contig AE016825_GR.
KEGGcvi:CV_0251.
NMPDRfig|243365.1.peg.251.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ7P1G2.
OMAQ7P1G2. IAQREFT.

Enzyme and pathway databases

BioCycCVIO243365:CV_0251-MON.
BRENDA2.7.1.30. 415.

Family and domain databases

HAMAPMF_00186.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. False negative.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameGLPK_CHRVO
AccessionPrimary (citable) accession number: Q7P1G2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: December 15, 2003
Last modified: June 16, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents