ID   HUTI_CHRVO              Reviewed;         413 AA.
AC   Q7P192;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   16-JUN-2009, entry version 37.
DE   RecName: Full=Imidazolonepropionase;
DE            EC=3.5.2.7;
DE   AltName: Full=Imidazolone-5-propionate hydrolase;
GN   Name=hutI; OrderedLocusNames=CV_0321;
OS   Chromobacterium violaceum.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales;
OC   Neisseriaceae; Chromobacterium.
OX   NCBI_TaxID=536;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12472 / DSM 30191 / IFO 12614 / JCM 1249 / NCIB 9131;
RX   MEDLINE=22882880; PubMed=14500782; DOI=10.1073/pnas.1832124100;
RA   Vasconcelos A.T.R., de Almeida D.F., Hungria M., Guimaraes C.T.,
RA   Antonio R.V., Almeida F.C., de Almeida L.G.P., de Almeida R.,
RA   Alves-Gomes J.A., Andrade E.M., Araripe J., de Araujo M.F.F.,
RA   Astolfi-Filho S., Azevedo V., Baptista A.J., Bataus L.A.M.,
RA   Batista J.S., Belo A., van den Berg C., Bogo M., Bonatto S.,
RA   Bordignon J., Brigido M.M., Brito C.A., Brocchi M., Burity H.A.,
RA   Camargo A.A., Cardoso D.D.P., Carneiro N.P., Carraro D.M.,
RA   Carvalho C.M.B., Cascardo J.C.M., Cavada B.S., Chueire L.M.O.,
RA   Creczynski-Pasa T.B., Cunha-Junior N.C., Fagundes N., Falcao C.L.,
RA   Fantinatti F., Farias I.P., Felipe M.S.S., Ferrari L.P., Ferro J.A.,
RA   Ferro M.I.T., Franco G.R., Freitas N.S.A., Furlan L.R.,
RA   Gazzinelli R.T., Gomes E.A., Goncalves P.R., Grangeiro T.B.,
RA   Grattapaglia D., Grisard E.C., Hanna E.S., Jardim S.N., Laurino J.,
RA   Leoi L.C.T., Lima L.F.A., Loureiro M.F., Lyra M.C.C.P.,
RA   Madeira H.M.F., Manfio G.P., Maranhao A.Q., Martins W.S.,
RA   di Mauro S.M.Z., de Medeiros S.R.B., Meissner R.V., Moreira M.A.M.,
RA   Nascimento F.F., Nicolas M.F., Oliveira J.G., Oliveira S.C.,
RA   Paixao R.F.C., Parente J.A., Pedrosa F.O., Pena S.D.J., Pereira J.O.,
RA   Pereira M., Pinto L.S.R.C., Pinto L.S., Porto J.I.R., Potrich D.P.,
RA   Ramalho-Neto C.E., Reis A.M.M., Rigo L.U., Rondinelli E.,
RA   Santos E.B.P., Santos F.R., Schneider M.P.C., Seuanez H.N.,
RA   Silva A.M.R., da Silva A.L.C., Silva D.W., Silva R., Simoes I.C.,
RA   Simon D., Soares C.M.A., Soares R.B.A., Souza E.M., Souza K.R.L.,
RA   Souza R.C., Steffens M.B.R., Steindel M., Teixeira S.R., Urmenyi T.,
RA   Vettore A., Wassem R., Zaha A., Simpson A.J.G.;
RT   "The complete genome sequence of Chromobacterium violaceum reveals
RT   remarkable and exploitable bacterial adaptability.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:11660-11665(2003).
CC   -!- CATALYTIC ACTIVITY: (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-
CC       yl)propanoate + H(2)O = N-formimidoyl-L-glutamate + H(+).
CC   -!- COFACTOR: Binds 1 zinc or iron ion per subunit (By similarity).
CC   -!- PATHWAY: Amino-acid degradation; L-histidine degradation into L-
CC       glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the hutI family.
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DR   EMBL; AE016825; AAQ58000.1; -; Genomic_DNA.
DR   RefSeq; NP_899991.1; -.
DR   GeneID; 2550792; -.
DR   GenomeReviews; AE016825_GR; CV_0321.
DR   KEGG; cvi:CV_0321; -.
DR   NMPDR; fig|243365.1.peg.321; -.
DR   HOGENOM; Q7P192; -.
DR   OMA; Q7P192; MNMACTL.
DR   BioCyc; CVIO243365:CV_0321-MON; -.
DR   BRENDA; 3.5.2.7; 415.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0050480; F:imidazolonepropionase activity; IEA:HAMAP.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019556; P:histidine catabolic process to glutamate an...; IEA:InterPro.
DR   HAMAP; MF_00372; -; 1.
DR   InterPro; IPR006680; Amidohydro_1.
DR   InterPro; IPR005920; HutI.
DR   Pfam; PF01979; Amidohydro_1; 2.
DR   ProDom; PD001248; Amidohydro_like; 1.
DR   TIGRFAMs; TIGR01224; hutI; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Histidine metabolism; Hydrolase; Iron;
KW   Metal-binding; Zinc.
FT   CHAIN         1    413       Imidazolonepropionase.
FT                                /FTId=PRO_0000306456.
FT   METAL        77     77       Zinc or iron (By similarity).
FT   METAL        79     79       Zinc or iron (By similarity).
FT   METAL       247    247       Zinc or iron (By similarity).
FT   METAL       322    322       Zinc or iron (By similarity).
FT   BINDING      86     86       Substrate (By similarity).
FT   BINDING      99     99       Substrate (By similarity).
FT   BINDING     149    149       Substrate (By similarity).
FT   BINDING     182    182       Substrate (By similarity).
FT   BINDING     250    250       Substrate (By similarity).
SQ   SEQUENCE   413 AA;  43634 MW;  FA4D8A5F69C02F5F CRC64;
     MNVPHPHRPS LWLNARLATM DPAHGAPYGA LEGHALLLRD GHIEAVLPQA EADAAAFDGE
     VFDLQGRWVT PGFVDCHTHL VYGGSRAAEW EKRLTGVPYQ QIAAEGGGIV STVRATRWLD
     EEELALASLP RLKALMAEGV TTVEIKSGYG LTLADELKQL AAARRLQASL PVEVATTLLA
     AHAVPPEYAG DADGYVDLVV ESILPVAARA GLAEAVDAFC ESVGFSPAQT RRVFEAARAH
     GLKVKGHVEQ LSNLHGAELV AEFGGLSADH IEYLDDAGVA ALKRAGTVAV LLPGAFYFLR
     ETQKPPVDKL RAAGVPMAVS TDLNPGTSPF ASIRLAMNQA CVLFGLTPEE ALAGVTRHAA
     QALGRGATHG RLAAGCVADL LVWDIAHPAE LAYSVGVPLL KQRVFRGAAQ HID
//