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Protein

Agmatinase

Gene

speB

Organism
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of putrescine from agmatine.UniRule annotation

Catalytic activityi

Agmatine + H2O = putrescine + urea.UniRule annotation

Cofactori

Mn2+UniRule annotation

Pathwayi: putrescine biosynthesis via agmatine pathway

This protein is involved in step 1 of the subpathway that synthesizes putrescine from agmatine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Agmatinase (speB)
This subpathway is part of the pathway putrescine biosynthesis via agmatine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from agmatine, the pathway putrescine biosynthesis via agmatine pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi136ManganeseUniRule annotation1
Metal bindingi160ManganeseUniRule annotation1
Metal bindingi162ManganeseUniRule annotation1
Metal bindingi164ManganeseUniRule annotation1
Metal bindingi243ManganeseUniRule annotation1
Metal bindingi245ManganeseUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPolyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis
LigandManganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00534; UER00287

Names & Taxonomyi

Protein namesi
Recommended name:
AgmatinaseUniRule annotation (EC:3.5.3.11UniRule annotation)
Alternative name(s):
Agmatine ureohydrolaseUniRule annotation
Short name:
AUHUniRule annotation
Gene namesi
Name:speBUniRule annotation
Ordered Locus Names:CV_0490
OrganismiChromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Taxonomic identifieri243365 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeChromobacterium
Proteomesi
  • UP000001424 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001737301 – 322AgmatinaseAdd BLAST322

Proteomic databases

PRIDEiQ7P0S6

Interactioni

Protein-protein interaction databases

STRINGi243365.CV_0490

Structurei

3D structure databases

ProteinModelPortaliQ7P0S6
SMRiQ7P0S6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family. Agmatinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CYW Bacteria
COG0010 LUCA
HOGENOMiHOG000204320
KOiK01480
OMAiDTYFGAE
OrthoDBiPOG091H0384

Family and domain databases

HAMAPiMF_01418 SpeB, 1 hit
InterProiView protein in InterPro
IPR023694 Agmatinase
IPR005925 Agmatinase-rel
IPR006035 Ureohydrolase
IPR023696 Ureohydrolase_dom_sf
IPR020855 Ureohydrolase_Mn_BS
PfamiView protein in Pfam
PF00491 Arginase, 1 hit
PIRSFiPIRSF036979 Arginase, 1 hit
SUPFAMiSSF52768 SSF52768, 1 hit
TIGRFAMsiTIGR01230 agmatinase, 1 hit
PROSITEiView protein in PROSITE
PS01053 ARGINASE_1, 1 hit
PS51409 ARGINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7P0S6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDEMIYGDG AIRRQGLYGS SIENTYAGVL SFMRRNYSRD LEGVDVAVSG
60 70 80 90 100
IPLDLSVTFR SGARMGPQAI RAASVQLAEL KPYPWGFDPF EDLAVVDYGD
110 120 130 140 150
CWFDAHNPLT IKPSIIEHAR TILASGAKML TFGGDHYVTY PLLIAHAEKY
160 170 180 190 200
GKPLALLHFD AHCDTWPDDS PDSLNHGTMF YKAVKEGLID PKKSVQVGIR
210 220 230 240 250
TWNDDFMGLN VLGAPWVHDN GVDATIAEIK KTIGDAPVYV TFDIDCLDPS
260 270 280 290 300
AAPGTGTPVP GGLTTAQALK IIRNLGDLNI VGMDVVEVAP SYDQSEITAI
310 320
AAAHIACDML CLMRNKKVAG TL
Length:322
Mass (Da):34,861
Last modified:December 15, 2003 - v1
Checksum:iEC6BE7759F34D694
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016825 Genomic DNA Translation: AAQ58167.1
RefSeqiWP_011134045.1, NC_005085.1

Genome annotation databases

EnsemblBacteriaiAAQ58167; AAQ58167; CV_0490
GeneIDi24945213
KEGGicvi:CV_0490

Similar proteinsi

Entry informationi

Entry nameiSPEB_CHRVO
AccessioniPrimary (citable) accession number: Q7P0S6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: December 15, 2003
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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