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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei635ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCVIO243365:G1G08-512-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CV_0505
OrganismiChromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Taxonomic identifieri243365 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeChromobacterium
Proteomesi
  • UP000001424 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001520011 – 872Leucine--tRNA ligaseAdd BLAST872

Proteomic databases

PRIDEiQ7P0R1

Interactioni

Protein-protein interaction databases

STRINGi243365.CV_0505

Structurei

3D structure databases

ProteinModelPortaliQ7P0R1
SMRiQ7P0R1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi632 – 636"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q7P0R1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEQYSPRAV EAAAQQKWQK TAAFKAVEDA SRPKYYALSM FPYPSGKLHM
60 70 80 90 100
GHVRNYTITD VLARFKRLQG FNVLQPMGWD AFGLPAENAA MKNGGAPAAW
110 120 130 140 150
TYANIEYMKT QLDSLGFALD WERELATCKP DYYRWEQWLF TRLFEKGVIY
160 170 180 190 200
KKNGVVNWDP VDQTVLANEQ VVDGRGWRSG ALVEKREIPM YYFRITDYAE
210 220 230 240 250
QLLADLDKLD GWPEQVKTMQ RNWIGKSYGS DVVFPYDEAS IGHAGELKVY
260 270 280 290 300
TTRPDTLMGA TYVAVAAEHP LATQAAAGNA ALQAFIAECK SGSVAEADVA
310 320 330 340 350
KMEKKGMDTG LSVIHPLTGE RLPVWVANYV LWGYGEGAVM AVPAHDERDF
360 370 380 390 400
EFANKYQLPI KQVIALASGD GEYDAANWQE WYGAKDDTVK TVNSGKYDGL
410 420 430 440 450
GYQAAFDAII GDLQAKSLGQ KKTQYRLRDW GISRQRYWGC PIPIIHCPSC
460 470 480 490 500
GDVPVPEKDL PVTLPENVIP DGAGSPLAKM PEFYETSCPK CGGAAKRETD
510 520 530 540 550
TMDTFVESSW YYARYASPKC DTAMVDKQAA DYWLQVDQYV GGIEHAILHL
560 570 580 590 600
LYARFFHKLM RDEGLVSSDE PFKSLLTQGM VVCETFYRDL PNGTKDWIAP
610 620 630 640 650
QDVILERDAK GKIVAAKHRV DGQPVVVGGI EKMSKSKNNG VDPQEFIEKY
660 670 680 690 700
GADTARLFMM FAAPPEQSLE WSDAGVEGAF RFLKRLWKTA REHVEAGVVA
710 720 730 740 750
PYASGELNAS QKELRFKLHG TIQKVADDYG RRQQFNTAIA AVMELLNAYD
760 770 780 790 800
KADTSGDIGR AVAQEVLEAA TLLLSPIVPH VCDGIWNALK PGTELLAQAW
810 820 830 840 850
PKVDEAALVK SEIELMVQVC GKLRGSVTVA ADAAKDAIEA AALAHENVIK
860 870
FMEGKPAKKI IVVPGRLVNI VV
Length:872
Mass (Da):96,741
Last modified:December 15, 2003 - v1
Checksum:iC30AC54B2A37BB78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016825 Genomic DNA Translation: AAQ58182.1
RefSeqiWP_011134060.1, NC_005085.1

Genome annotation databases

EnsemblBacteriaiAAQ58182; AAQ58182; CV_0505
GeneIDi24948117
KEGGicvi:CV_0505

Similar proteinsi

Entry informationi

Entry nameiSYL_CHRVO
AccessioniPrimary (citable) accession number: Q7P0R1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: December 15, 2003
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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