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Protein

Ribosomal protein S12 methylthiotransferase RimO

Gene

rimO

Organism
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.UniRule annotation

Catalytic activityi

L-aspartate-[ribosomal protein S12] + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 3-methylthio-L-aspartate-[ribosomal protein S12] + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine.UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi14Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi50Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi79Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi146Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation1
Metal bindingi150Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation1
Metal bindingi153Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCVIO243365:G1G08-1390-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal protein S12 methylthiotransferase RimOUniRule annotation (EC:2.8.4.4UniRule annotation)
Short name:
S12 MTTaseUniRule annotation
Short name:
S12 methylthiotransferaseUniRule annotation
Alternative name(s):
Ribosomal protein S12 (aspartate-C(3))-methylthiotransferaseUniRule annotation
Ribosome maturation factor RimOUniRule annotation
Gene namesi
Name:rimOUniRule annotation
Ordered Locus Names:CV_1373
OrganismiChromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Taxonomic identifieri243365 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeChromobacterium
Proteomesi
  • UP000001424 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003747721 – 438Ribosomal protein S12 methylthiotransferase RimOAdd BLAST438

Interactioni

Protein-protein interaction databases

STRINGi243365.CV_1373

Structurei

3D structure databases

ProteinModelPortaliQ7NYA1
SMRiQ7NYA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 115MTTase N-terminalUniRule annotationAdd BLAST111
Domaini372 – 438TRAMUniRule annotationAdd BLAST67

Sequence similaritiesi

Belongs to the methylthiotransferase family. RimO subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBM Bacteria
COG0621 LUCA
HOGENOMiHOG000224766
KOiK14441
OMAiCLSERYK
OrthoDBiPOG091H006S

Family and domain databases

Gene3Di3.40.50.12160, 1 hit
3.80.30.20, 1 hit
HAMAPiMF_01865 MTTase_RimO, 1 hit
InterProiView protein in InterPro
IPR006638 Elp3/MiaB/NifB
IPR005839 Methylthiotransferase
IPR020612 Methylthiotransferase_CS
IPR013848 Methylthiotransferase_N
IPR038135 Methylthiotransferase_N_sf
IPR005840 Ribosomal_S12_MeSTrfase_RimO
IPR007197 rSAM
IPR023404 rSAM_horseshoe
IPR002792 TRAM_dom
PANTHERiPTHR43837 PTHR43837, 1 hit
PfamiView protein in Pfam
PF04055 Radical_SAM, 1 hit
PF00919 UPF0004, 1 hit
SFLDiSFLDF00274 ribosomal_protein_S12_methylth, 1 hit
SFLDG01061 methylthiotransferase, 1 hit
SFLDS00029 Radical_SAM, 1 hit
SMARTiView protein in SMART
SM00729 Elp3, 1 hit
TIGRFAMsiTIGR00089 TIGR00089, 1 hit
TIGR01125 TIGR01125, 1 hit
PROSITEiView protein in PROSITE
PS51449 MTTASE_N, 1 hit
PS01278 MTTASE_RADICAL, 1 hit
PS50926 TRAM, 1 hit

Sequencei

Sequence statusi: Complete.

Q7NYA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKTPRVGFV SLGCPKAASD SEQILTRLRA EGYEIAPSYD GADLVVVNTC
60 70 80 90 100
GFIDSAVEES LDAIGEALNE NGKVIVTGCL GAKGDVVRDV HPSVLAVTGP
110 120 130 140 150
HATEEVMSAV HTHLPKPHDP FVDLVPDIGV RLTPKHYAYL KISEGCNHRC
160 170 180 190 200
TFCIIPSMRG DLESRPIHDV LREAESLAKA GVKEILVISQ DTSAYGVDTK
210 220 230 240 250
YKLGFHNGRP VKTRMTELCE ELGRHGIWVR LHYVYPYPHV DEVIPLMRDG
260 270 280 290 300
KILPYLDIPF QHASQKVLKL MKRPANSDNV LARIKKWREI CPELVIRSTF
310 320 330 340 350
IVGFPGETEE DFEELLAFIR EAELDRVGCF TYSPVEGATA NELPNPVPED
360 370 380 390 400
VKEARKERFM AVQAEISARR LERRVGQTLQ VLVDEIDDEG TAVCRSYADA
410 420 430
PEIDGLVFVE DAAGMQPGEF YQVEIVDCSE HDLWGERR
Length:438
Mass (Da):48,761
Last modified:December 15, 2003 - v1
Checksum:iEAEF26572EF827C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016825 Genomic DNA Translation: AAQ59048.1
RefSeqiWP_011134927.1, NC_005085.1

Genome annotation databases

EnsemblBacteriaiAAQ59048; AAQ59048; CV_1373
GeneIDi24947534
KEGGicvi:CV_1373

Similar proteinsi

Entry informationi

Entry nameiRIMO_CHRVO
AccessioniPrimary (citable) accession number: Q7NYA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: December 15, 2003
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health