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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei243ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCVIO243365:G1G08-1945-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:CV_1937
OrganismiChromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Taxonomic identifieri243365 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeChromobacterium
Proteomesi
  • UP000001424 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001195431 – 461Glutamate--tRNA ligaseAdd BLAST461

Proteomic databases

PRIDEiQ7NWP4

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi243365.CV_1937

Structurei

3D structure databases

ProteinModelPortaliQ7NWP4
SMRiQ7NWP4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi8 – 18"HIGH" regionUniRule annotationAdd BLAST11
Motifi240 – 244"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q7NWP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRTRFAPSP TGYLHIGGVR TALFSWAYAR KNNGVFVLRI EDTDLERSTP
60 70 80 90 100
ESVKAILDGM HWVGLDYDEG PFYQTHRFDR YKEVIQQLLD SGHAYHCYCS
110 120 130 140 150
KEELEAMRAE QEARGDKPRY DRRWRPEAGK TLPAIPEGVQ PVVRFKTPLS
160 170 180 190 200
GVVAWDDAVK GRIEISNEEL DDLIIARPDG SPTYNFCVVV DDWDMRITHV
210 220 230 240 250
IRGDDHVNNT PRQINILKAL NAPLPVYGHL PMILNEDGQK MSKRRDAVSV
260 270 280 290 300
VDYADKGILP EALLNYLARL GWGHGDDEFF SMEQFVEWFS LEAVSPSASR
310 320 330 340 350
FNHEKFMWLN AQHIKAADNA RLAELIAPRL AAAHVDTAHG PAIGDVLALV
360 370 380 390 400
KERVQDLNAL ALEVDYFYKK REPAAADVEK HLAGDAVERM GRFADRLAAL
410 420 430 440 450
EAWTAESIHE LFKPFCADEG IKMGQLGMPL RVLVCGTTQT PSVDAVLALI
460
GKEEVLRRIR G
Length:461
Mass (Da):51,913
Last modified:December 15, 2003 - v1
Checksum:i78524B818339D54F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016825 Genomic DNA Translation: AAQ59611.1
RefSeqiWP_011135488.1, NC_005085.1

Genome annotation databases

EnsemblBacteriaiAAQ59611; AAQ59611; CV_1937
GeneIDi24945306
KEGGicvi:CV_1937

Similar proteinsi

Entry informationi

Entry nameiSYE_CHRVO
AccessioniPrimary (citable) accession number: Q7NWP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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