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Q7NWG4

- Q7NWG4_CHRVO

UniProt

Q7NWG4 - Q7NWG4_CHRVO

Protein
Submitted name:

Probable aminotransferase

Gene

CV_2025

Organism
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi104 – 1041Sodium; via carbonyl oxygen
    Metal bindingi107 – 1071Sodium
    Metal bindingi108 – 1081Sodium; via carbonyl oxygen
    Binding sitei288 – 2881N6-(pyridoxalphosphate)lysine (covalent)Imported
    Binding sitei347 – 3471Sulfate
    Binding sitei432 – 4321Sulfate; via amide nitrogen

    GO - Molecular functioni

    1. adenosylmethionine-8-amino-7-oxononanoate transaminase activity Source: UniProtKB-EC
    2. identical protein binding Source: IntAct
    3. metal ion binding Source: UniProtKB-KW
    4. pyridoxal phosphate binding Source: InterPro

    Keywords - Molecular functioni

    AminotransferaseImported, Transferase

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciCVIO243365:GHUD-2080-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Probable aminotransferaseImported (EC:2.6.1.62Imported)
    Gene namesi
    Ordered Locus Names:CV_2025Imported
    OrganismiChromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)Imported
    Taxonomic identifieri243365 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeChromobacterium
    ProteomesiUP000001424: Chromosome

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself3EBI-7663449,EBI-7663449

    Protein-protein interaction databases

    MINTiMINT-8300509.
    STRINGi243365.CV_2025.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4A6RX-ray1.35A/B1-459[»]
    4A6TX-ray1.80A/B/C/D1-459[»]
    4A6UX-ray1.69A/B1-459[»]
    4A72X-ray2.40A/B/C/D1-459[»]
    4AH3X-ray1.57A/B/C/D1-459[»]
    4BA4X-ray1.73A/B1-459[»]
    4BA5X-ray1.76A/B1-459[»]
    ProteinModelPortaliQ7NWG4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000020207.
    KOiK12256.
    OMAiNDTGPYF.
    OrthoDBiEOG6W71WN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    InterProiIPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7NWG4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKQRTTSQW RELDAAHHLH PFTDTASLNQ AGARVMTRGE GVYLWDSEGN    50
    KIIDGMAGLW CVNVGYGRKD FAEAARRQME ELPFYNTFFK TTHPAVVELS 100
    SLLAEVTPAG FDRVFYTNSG SESVDTMIRM VRRYWDVQGK PEKKTLIGRW 150
    NGYHGSTIGG ASLGGMKYMH EQGDLPIPGM AHIEQPWWYK HGKDMTPDEF 200
    GVVAARWLEE KILEIGADKV AAFVGEPIQG AGGVIVPPAT YWPEIERICR 250
    KYDVLLVADE VICGFGRTGE WFGHQHFGFQ PDLFTAAKGL SSGYLPIGAV 300
    FVGKRVAEGL IAGGDFNHGF TYSGHPVCAA VAHANVAALR DEGIVQRVKD 350
    DIGPYMQKRW RETFSRFEHV DDVRGVGMVQ AFTLVKNKAK RELFPDFGEI 400
    GTLCRDIFFR NNLIMRACGD HIVSAPPLVM TRAEVDEMLA VAERCLEEFE 450
    QTLKARGLA 459
    Length:459
    Mass (Da):51,213
    Last modified:December 15, 2003 - v1
    Checksum:i5CD2CC1AF273D260
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016825 Genomic DNA. Translation: AAQ59697.1.
    RefSeqiNP_901695.1. NC_005085.1.
    WP_011135573.1. NC_005085.1.

    Genome annotation databases

    EnsemblBacteriaiAAQ59697; AAQ59697; CV_2025.
    GeneIDi2547848.
    KEGGicvi:CV_2025.
    PATRICi21438840. VBIChrVio67196_1976.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016825 Genomic DNA. Translation: AAQ59697.1 .
    RefSeqi NP_901695.1. NC_005085.1.
    WP_011135573.1. NC_005085.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4A6R X-ray 1.35 A/B 1-459 [» ]
    4A6T X-ray 1.80 A/B/C/D 1-459 [» ]
    4A6U X-ray 1.69 A/B 1-459 [» ]
    4A72 X-ray 2.40 A/B/C/D 1-459 [» ]
    4AH3 X-ray 1.57 A/B/C/D 1-459 [» ]
    4BA4 X-ray 1.73 A/B 1-459 [» ]
    4BA5 X-ray 1.76 A/B 1-459 [» ]
    ProteinModelPortali Q7NWG4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-8300509.
    STRINGi 243365.CV_2025.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAQ59697 ; AAQ59697 ; CV_2025 .
    GeneIDi 2547848.
    KEGGi cvi:CV_2025.
    PATRICi 21438840. VBIChrVio67196_1976.

    Phylogenomic databases

    HOGENOMi HOG000020207.
    KOi K12256.
    OMAi NDTGPYF.
    OrthoDBi EOG6W71WN.

    Enzyme and pathway databases

    BioCyci CVIO243365:GHUD-2080-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    InterProi IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability."
      Vasconcelos A.T.R., de Almeida D.F., Hungria M., Guimaraes C.T., Antonio R.V., Almeida F.C., de Almeida L.G.P., de Almeida R., Alves-Gomes J.A., Andrade E.M., Araripe J., de Araujo M.F.F., Astolfi-Filho S., Azevedo V., Baptista A.J., Bataus L.A.M., Batista J.S., Belo A.
      , van den Berg C., Bogo M., Bonatto S., Bordignon J., Brigido M.M., Brito C.A., Brocchi M., Burity H.A., Camargo A.A., Cardoso D.D.P., Carneiro N.P., Carraro D.M., Carvalho C.M.B., Cascardo J.C.M., Cavada B.S., Chueire L.M.O., Creczynski-Pasa T.B., Cunha-Junior N.C., Fagundes N., Falcao C.L., Fantinatti F., Farias I.P., Felipe M.S.S., Ferrari L.P., Ferro J.A., Ferro M.I.T., Franco G.R., Freitas N.S.A., Furlan L.R., Gazzinelli R.T., Gomes E.A., Goncalves P.R., Grangeiro T.B., Grattapaglia D., Grisard E.C., Hanna E.S., Jardim S.N., Laurino J., Leoi L.C.T., Lima L.F.A., Loureiro M.F., Lyra M.C.C.P., Madeira H.M.F., Manfio G.P., Maranhao A.Q., Martins W.S., di Mauro S.M.Z., de Medeiros S.R.B., Meissner R.V., Moreira M.A.M., Nascimento F.F., Nicolas M.F., Oliveira J.G., Oliveira S.C., Paixao R.F.C., Parente J.A., Pedrosa F.O., Pena S.D.J., Pereira J.O., Pereira M., Pinto L.S.R.C., Pinto L.S., Porto J.I.R., Potrich D.P., Ramalho-Neto C.E., Reis A.M.M., Rigo L.U., Rondinelli E., Santos E.B.P., Santos F.R., Schneider M.P.C., Seuanez H.N., Silva A.M.R., da Silva A.L.C., Silva D.W., Silva R., Simoes I.C., Simon D., Soares C.M.A., Soares R.B.A., Souza E.M., Souza K.R.L., Souza R.C., Steffens M.B.R., Steindel M., Teixeira S.R., Urmenyi T., Vettore A., Wassem R., Zaha A., Simpson A.J.G.
      Proc. Natl. Acad. Sci. U.S.A. 100:11660-11665(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757Imported.
    2. "Crystal structures of the Chromobacterium violaceum?-transaminase reveal major structural rearrangements upon binding of coenzyme PLP."
      Humble M.S., Cassimjee K.E., Hakansson M., Kimbung Y.R., Walse B., Abedi V., Federsel H.J., Berglund P., Logan D.T.
      FEBS J. 279:779-792(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) IN COMPLEX WITH N6-(PYRIDOXALPHOSPHATE)LYSINE.
    3. "Structural studies of Pseudomonas and Chromobacterium omega-aminotransferases provide insights into their differing substrate specificity."
      Sayer C., Isupov M.N., Westlake A., Littlechild J.A.
      Acta Crystallogr. D 69:564-576(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.57 ANGSTROMS) IN COMPLEX WITH N6-(PYRIDOXALPHOSPHATE)LYSINE.

    Entry informationi

    Entry nameiQ7NWG4_CHRVO
    AccessioniPrimary (citable) accession number: Q7NWG4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 15, 2003
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3