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Q7NWG4

- Q7NWG4_CHRVO

UniProt

Q7NWG4 - Q7NWG4_CHRVO

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Protein
Submitted name:

Probable aminotransferase

Gene
CV_2025
Organism
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi104 – 1041Sodium; via carbonyl oxygen
Metal bindingi107 – 1071Sodium
Metal bindingi108 – 1081Sodium; via carbonyl oxygen
Binding sitei347 – 3471Sulfate
Binding sitei432 – 4321Sulfate; via amide nitrogen

GO - Molecular functioni

  1. adenosylmethionine-8-amino-7-oxononanoate transaminase activity Source: UniProtKB-EC
  2. identical protein binding Source: IntAct
  3. metal ion binding Source: UniProtKB-KW
  4. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AminotransferaseImported, Transferase

Keywords - Ligandi

Metal-bindingImported, Pyridoxal phosphateUniRule annotation, SodiumImported

Enzyme and pathway databases

BioCyciCVIO243365:GHUD-2080-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Probable aminotransferaseImported (EC:2.6.1.62Imported)
Gene namesi
Ordered Locus Names:CV_2025Imported
OrganismiChromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Taxonomic identifieri243365 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeChromobacterium
ProteomesiUP000001424: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei288 – 2881N6-(pyridoxal phosphate)lysineImported

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-7663449,EBI-7663449

Protein-protein interaction databases

MINTiMINT-8300509.
STRINGi243365.CV_2025.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4A6RX-ray1.35A/B1-459[»]
4A6TX-ray1.80A/B/C/D1-459[»]
4A6UX-ray1.69A/B1-459[»]
4A72X-ray2.40A/B/C/D1-459[»]
4AH3X-ray1.57A/B/C/D1-459[»]
4BA4X-ray1.73A/B1-459[»]
4BA5X-ray1.76A/B1-459[»]
ProteinModelPortaliQ7NWG4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000020207.
KOiK12256.
OMAiNDTGPYF.
OrthoDBiEOG6W71WN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7NWG4-1 [UniParc]FASTAAdd to Basket

« Hide

MQKQRTTSQW RELDAAHHLH PFTDTASLNQ AGARVMTRGE GVYLWDSEGN    50
KIIDGMAGLW CVNVGYGRKD FAEAARRQME ELPFYNTFFK TTHPAVVELS 100
SLLAEVTPAG FDRVFYTNSG SESVDTMIRM VRRYWDVQGK PEKKTLIGRW 150
NGYHGSTIGG ASLGGMKYMH EQGDLPIPGM AHIEQPWWYK HGKDMTPDEF 200
GVVAARWLEE KILEIGADKV AAFVGEPIQG AGGVIVPPAT YWPEIERICR 250
KYDVLLVADE VICGFGRTGE WFGHQHFGFQ PDLFTAAKGL SSGYLPIGAV 300
FVGKRVAEGL IAGGDFNHGF TYSGHPVCAA VAHANVAALR DEGIVQRVKD 350
DIGPYMQKRW RETFSRFEHV DDVRGVGMVQ AFTLVKNKAK RELFPDFGEI 400
GTLCRDIFFR NNLIMRACGD HIVSAPPLVM TRAEVDEMLA VAERCLEEFE 450
QTLKARGLA 459
Length:459
Mass (Da):51,213
Last modified:December 15, 2003 - v1
Checksum:i5CD2CC1AF273D260
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016825 Genomic DNA. Translation: AAQ59697.1.
RefSeqiNP_901695.1. NC_005085.1.
WP_011135573.1. NC_005085.1.

Genome annotation databases

EnsemblBacteriaiAAQ59697; AAQ59697; CV_2025.
GeneIDi2547848.
KEGGicvi:CV_2025.
PATRICi21438840. VBIChrVio67196_1976.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016825 Genomic DNA. Translation: AAQ59697.1 .
RefSeqi NP_901695.1. NC_005085.1.
WP_011135573.1. NC_005085.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4A6R X-ray 1.35 A/B 1-459 [» ]
4A6T X-ray 1.80 A/B/C/D 1-459 [» ]
4A6U X-ray 1.69 A/B 1-459 [» ]
4A72 X-ray 2.40 A/B/C/D 1-459 [» ]
4AH3 X-ray 1.57 A/B/C/D 1-459 [» ]
4BA4 X-ray 1.73 A/B 1-459 [» ]
4BA5 X-ray 1.76 A/B 1-459 [» ]
ProteinModelPortali Q7NWG4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-8300509.
STRINGi 243365.CV_2025.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAQ59697 ; AAQ59697 ; CV_2025 .
GeneIDi 2547848.
KEGGi cvi:CV_2025.
PATRICi 21438840. VBIChrVio67196_1976.

Phylogenomic databases

HOGENOMi HOG000020207.
KOi K12256.
OMAi NDTGPYF.
OrthoDBi EOG6W71WN.

Enzyme and pathway databases

BioCyci CVIO243365:GHUD-2080-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProi IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability."
    Vasconcelos A.T.R., de Almeida D.F., Hungria M., Guimaraes C.T., Antonio R.V., Almeida F.C., de Almeida L.G.P., de Almeida R., Alves-Gomes J.A., Andrade E.M., Araripe J., de Araujo M.F.F., Astolfi-Filho S., Azevedo V., Baptista A.J., Bataus L.A.M., Batista J.S., Belo A.
    , van den Berg C., Bogo M., Bonatto S., Bordignon J., Brigido M.M., Brito C.A., Brocchi M., Burity H.A., Camargo A.A., Cardoso D.D.P., Carneiro N.P., Carraro D.M., Carvalho C.M.B., Cascardo J.C.M., Cavada B.S., Chueire L.M.O., Creczynski-Pasa T.B., Cunha-Junior N.C., Fagundes N., Falcao C.L., Fantinatti F., Farias I.P., Felipe M.S.S., Ferrari L.P., Ferro J.A., Ferro M.I.T., Franco G.R., Freitas N.S.A., Furlan L.R., Gazzinelli R.T., Gomes E.A., Goncalves P.R., Grangeiro T.B., Grattapaglia D., Grisard E.C., Hanna E.S., Jardim S.N., Laurino J., Leoi L.C.T., Lima L.F.A., Loureiro M.F., Lyra M.C.C.P., Madeira H.M.F., Manfio G.P., Maranhao A.Q., Martins W.S., di Mauro S.M.Z., de Medeiros S.R.B., Meissner R.V., Moreira M.A.M., Nascimento F.F., Nicolas M.F., Oliveira J.G., Oliveira S.C., Paixao R.F.C., Parente J.A., Pedrosa F.O., Pena S.D.J., Pereira J.O., Pereira M., Pinto L.S.R.C., Pinto L.S., Porto J.I.R., Potrich D.P., Ramalho-Neto C.E., Reis A.M.M., Rigo L.U., Rondinelli E., Santos E.B.P., Santos F.R., Schneider M.P.C., Seuanez H.N., Silva A.M.R., da Silva A.L.C., Silva D.W., Silva R., Simoes I.C., Simon D., Soares C.M.A., Soares R.B.A., Souza E.M., Souza K.R.L., Souza R.C., Steffens M.B.R., Steindel M., Teixeira S.R., Urmenyi T., Vettore A., Wassem R., Zaha A., Simpson A.J.G.
    Proc. Natl. Acad. Sci. U.S.A. 100:11660-11665(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757.
  2. "Crystal structures of the Chromobacterium violaceum?-transaminase reveal major structural rearrangements upon binding of coenzyme PLP."
    Humble M.S., Cassimjee K.E., Hakansson M., Kimbung Y.R., Walse B., Abedi V., Federsel H.J., Berglund P., Logan D.T.
    FEBS J. 279:779-792(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) IN COMPLEX WITH SODIUM, PYRIDOXAL PHOSPHATE AT LYS-288.
  3. "Structural studies of Pseudomonas and Chromobacterium ?-aminotransferases provide insights into their differing substrate specificity."
    Sayer C., Isupov M.N., Westlake A., Littlechild J.A.
    Acta Crystallogr. D 69:564-576(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.57 ANGSTROMS), PYRIDOXAL PHOSPHATE AT LYS-288.

Entry informationi

Entry nameiQ7NWG4_CHRVO
AccessioniPrimary (citable) accession number: Q7NWG4
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: December 15, 2003
Last modified: September 3, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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