Q7NWG4 (Q7NWG4_CHRVO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Probable aminotransferase EMBL AAQ59697.1
EC=2.6.1.62 EMBL AAQ59697.1

Gene names

Ordered Locus Names:

CV_2025

Organism

Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757) [Complete proteome] [HAMAP]

Taxonomic identifier

243365 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Chromobacterium group › Chromobacterium › Chromobacterium violaceum

Protein attributes

Sequence length	459 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. RuleBase RU003560

Ontologies

Keywords
Ligand	Pyridoxal phosphate RuleBase RU003560
Molecular function	Aminotransferase EMBL AAQ59697.1 Transferase
Technical term	3D-structure PDB 4AH3 PDB 4A6R PDB 4A6T PDB 4A6U PDB 4A72 PDB 4BA4 PDB 4BA5 Complete proteome
Gene Ontology (GO)
Biological_process	metabolic process Inferred from electronic annotation. Source: GOC
Molecular_function	adenosylmethionine-8-amino-7-oxononanoate transaminase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7NWG4 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 5CD2CC1AF273D260	FASTA	459	51,213
	10 20 30 40 50 60 MQKQRTTSQW RELDAAHHLH PFTDTASLNQ AGARVMTRGE GVYLWDSEGN KIIDGMAGLW 70 80 90 100 110 120 CVNVGYGRKD FAEAARRQME ELPFYNTFFK TTHPAVVELS SLLAEVTPAG FDRVFYTNSG 130 140 150 160 170 180 SESVDTMIRM VRRYWDVQGK PEKKTLIGRW NGYHGSTIGG ASLGGMKYMH EQGDLPIPGM 190 200 210 220 230 240 AHIEQPWWYK HGKDMTPDEF GVVAARWLEE KILEIGADKV AAFVGEPIQG AGGVIVPPAT 250 260 270 280 290 300 YWPEIERICR KYDVLLVADE VICGFGRTGE WFGHQHFGFQ PDLFTAAKGL SSGYLPIGAV 310 320 330 340 350 360 FVGKRVAEGL IAGGDFNHGF TYSGHPVCAA VAHANVAALR DEGIVQRVKD DIGPYMQKRW 370 380 390 400 410 420 RETFSRFEHV DDVRGVGMVQ AFTLVKNKAK RELFPDFGEI GTLCRDIFFR NNLIMRACGD 430 440 450 HIVSAPPLVM TRAEVDEMLA VAERCLEEFE QTLKARGLA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability." Vasconcelos A.T.R., de Almeida D.F., Hungria M., Guimaraes C.T., Antonio R.V., Almeida F.C., de Almeida L.G.P., de Almeida R., Alves-Gomes J.A., Andrade E.M., Araripe J., de Araujo M.F.F., Astolfi-Filho S., Azevedo V., Baptista A.J., Bataus L.A.M., Batista J.S., Belo A. , van den Berg C., Bogo M., Bonatto S., Bordignon J., Brigido M.M., Brito C.A., Brocchi M., Burity H.A., Camargo A.A., Cardoso D.D.P., Carneiro N.P., Carraro D.M., Carvalho C.M.B., Cascardo J.C.M., Cavada B.S., Chueire L.M.O., Creczynski-Pasa T.B., Cunha-Junior N.C., Fagundes N., Falcao C.L., Fantinatti F., Farias I.P., Felipe M.S.S., Ferrari L.P., Ferro J.A., Ferro M.I.T., Franco G.R., Freitas N.S.A., Furlan L.R., Gazzinelli R.T., Gomes E.A., Goncalves P.R., Grangeiro T.B., Grattapaglia D., Grisard E.C., Hanna E.S., Jardim S.N., Laurino J., Leoi L.C.T., Lima L.F.A., Loureiro M.F., Lyra M.C.C.P., Madeira H.M.F., Manfio G.P., Maranhao A.Q., Martins W.S., di Mauro S.M.Z., de Medeiros S.R.B., Meissner R.V., Moreira M.A.M., Nascimento F.F., Nicolas M.F., Oliveira J.G., Oliveira S.C., Paixao R.F.C., Parente J.A., Pedrosa F.O., Pena S.D.J., Pereira J.O., Pereira M., Pinto L.S.R.C., Pinto L.S., Porto J.I.R., Potrich D.P., Ramalho-Neto C.E., Reis A.M.M., Rigo L.U., Rondinelli E., Santos E.B.P., Santos F.R., Schneider M.P.C., Seuanez H.N., Silva A.M.R., da Silva A.L.C., Silva D.W., Silva R., Simoes I.C., Simon D., Soares C.M.A., Soares R.B.A., Souza E.M., Souza K.R.L., Souza R.C., Steffens M.B.R., Steindel M., Teixeira S.R., Urmenyi T., Vettore A., Wassem R., Zaha A., Simpson A.J.G. Proc. Natl. Acad. Sci. U.S.A. 100:11660-11665(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757.
[2]	"Crystal structures of the Chromobacterium violaceum?-transaminase reveal major structural rearrangements upon binding of coenzyme PLP." Humble M.S., Cassimjee K.E., Hakansson M., Kimbung Y.R., Walse B., Abedi V., Federsel H.J., Berglund P., Logan D.T. FEBS J. 279:779-792(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS).
[3]	"Structural studies of Pseudomonas and Chromobacterium ?-aminotransferases provide insights into their differing substrate specificity." Sayer C., Isupov M.N., Westlake A., Littlechild J.A. Acta Crystallogr. D 69:564-576(2013) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.57 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE016825 Genomic DNA. Translation: AAQ59697.1.

RefSeq

NP_901695.1. NC_005085.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4A6R	X-ray	1.35	A/B	1-459	[»]
4A6T	X-ray	1.80	A/B/C/D	1-459	[»]
4A6U	X-ray	1.69	A/B	1-459	[»]
4A72	X-ray	2.40	A/B/C/D	1-459	[»]
4AH3	X-ray	1.57	A/B/C/D	1-459	[»]
4BA4	X-ray	1.73	A/B	1-459	[»]
4BA5	X-ray	1.76	A/B	1-459	[»]

ProteinModelPortal

Q7NWG4.

ModBase

Search...

Protein-protein interaction databases

MINT

MINT-8300509.

STRING

243365.CV_2025.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAQ59697; AAQ59697; CV_2025.

GeneID

2547848.

KEGG

cvi:CV_2025.

PATRIC

21438840. VBIChrVio67196_1976.

Organism-specific databases

CMR

Search...

Phylogenomic databases

HOGENOM

HOG000020207.

KO

K12256.

OMA

FGAECQK.

ProtClustDB

PRK07480.

Enzyme and pathway databases

BioCyc

CVIO243365:GHUD-2080-MONOMER.

Family and domain databases

Gene3D

3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.

InterPro

IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]

PANTHER

PTHR11986. PTHR11986. 1 hit.

Pfam

PF00202. Aminotran_3. 1 hit.
[Graphical view]

SUPFAM

SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.

PROSITE

PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q7NWG4_CHRVO

Accession

Primary (citable) accession number: Q7NWG4

Entry history

Integrated into UniProtKB/TrEMBL:	December 15, 2003
Last sequence update:	December 15, 2003
Last modified:	May 29, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)