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Protein

Sulfate adenylyltransferase subunit 1

Gene

cysN

Organism
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May be the GTPase, regulating ATP sulfurylase activity.UniRule annotation

Catalytic activityi

ATP + sulfate = diphosphate + adenylyl sulfate.UniRule annotation

Pathwayi: hydrogen sulfide biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes sulfite from sulfate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Sulfate adenylyltransferase subunit 1 (cysN), Sulfate adenylyltransferase subunit 2 (cysD)
  2. Adenylyl-sulfate kinase (cysC)
  3. Phosphoadenylyl-sulfate reductase (cysH)
This subpathway is part of the pathway hydrogen sulfide biosynthesis, which is itself part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sulfite from sulfate, the pathway hydrogen sulfide biosynthesis and in Sulfur metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi31 – 38GTPUniRule annotation8
Nucleotide bindingi110 – 114GTPUniRule annotation5
Nucleotide bindingi165 – 168GTPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandATP-binding, GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCVIO243365:G1G08-2309-MONOMER
UniPathwayiUPA00140; UER00204

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfate adenylyltransferase subunit 1UniRule annotation (EC:2.7.7.4UniRule annotation)
Alternative name(s):
ATP-sulfurylase large subunitUniRule annotation
Sulfate adenylate transferaseUniRule annotation
Short name:
SATUniRule annotation
Gene namesi
Name:cysNUniRule annotation
Ordered Locus Names:CV_2307
OrganismiChromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Taxonomic identifieri243365 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeChromobacterium
Proteomesi
  • UP000001424 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000915211 – 477Sulfate adenylyltransferase subunit 1Add BLAST477

Proteomic databases

PRIDEiQ7NVN5

Interactioni

Subunit structurei

Heterodimer composed of CysD, the smaller subunit, and CysN.UniRule annotation

Protein-protein interaction databases

STRINGi243365.CV_2307

Structurei

3D structure databases

ProteinModelPortaliQ7NVN5
SMRiQ7NVN5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 239tr-type GAdd BLAST218

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni31 – 38G1By similarity8
Regioni89 – 93G2By similarity5
Regioni110 – 113G3By similarity4
Regioni165 – 168G4By similarity4
Regioni202 – 204G5By similarity3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3T Bacteria
COG2895 LUCA
HOGENOMiHOG000229289
KOiK00956
OMAiFDPYEQN
OrthoDBiPOG091H06C6

Family and domain databases

HAMAPiMF_00062 Sulf_adenylyltr_sub1, 1 hit
InterProiView protein in InterPro
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR011779 SO4_adenylTrfase_lsu
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR02034 CysN, 1 hit
PROSITEiView protein in PROSITE
PS00301 G_TR_1, 1 hit
PS51722 G_TR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7NVN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHQSELIAG DILEYLSQHE NKDMLRFITC GSVDDGKSTL IGRLLHDSKL
60 70 80 90 100
IFEDQLAAIE RDSKKYNTTD QDIDLALLVD GLQAEREQGI TIDVAYRYFS
110 120 130 140 150
TDKRKFIIAD CPGHEQYTRN MATGASTSNL AIILIDARRG VQTQTRRHSY
160 170 180 190 200
IVSLLGIRHV IVAVNKMDLV DYSEDVYNRI RDEYLTFAEH LDIPDIHFVP
210 220 230 240 250
ISALRGDNVV SRTEAAPWYQ GATLMHLLET VQISHDAPLS AFRLPVQYVN
260 270 280 290 300
RPNLDFRGFC GTIASGAVHP GDAVVALPSG KESRVKEIVT FDGSLSRAGA
310 320 330 340 350
GQAVTLTLED EIDISRGDML VRADEARPHV SRSFDAHLVA MGEAPLRPGK
360 370 380 390 400
EYGFKLAGKY VTGRIEAILH RTDVNTLQDS PADALALNEI GLCRISLNSP
410 420 430 440 450
AAFDAYRDCR GSGSLILIDR LSNGTVAAGM IVAQSEEASP AALSPWALFE
460 470
QELDQLLQRY FPQMTRAELA RRLRDEL
Length:477
Mass (Da):52,841
Last modified:December 15, 2003 - v1
Checksum:i2256306774D4BE87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016825 Genomic DNA Translation: AAQ59979.1
RefSeqiWP_011135854.1, NC_005085.1

Genome annotation databases

EnsemblBacteriaiAAQ59979; AAQ59979; CV_2307
GeneIDi24947089
KEGGicvi:CV_2307

Similar proteinsi

Entry informationi

Entry nameiCYSN_CHRVO
AccessioniPrimary (citable) accession number: Q7NVN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: March 28, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health