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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation
  • pyridoxal 5'-phosphateUniRule annotation

Pathwayi: agmatine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes agmatine from L-arginine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Biosynthetic arginine decarboxylase (speA)
This subpathway is part of the pathway agmatine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes agmatine from L-arginine, the pathway agmatine biosynthesis and in Amine and polyamine biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPolyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis
LigandMagnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCVIO243365:G1G08-2877-MONOMER
UniPathwayiUPA00186; UER00284

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
Ordered Locus Names:CV_2876
OrganismiChromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Taxonomic identifieri243365 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeChromobacterium
Proteomesi
  • UP000001424 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001499581 – 626Biosynthetic arginine decarboxylaseAdd BLAST626

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei99N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ7NU27

Interactioni

Protein-protein interaction databases

STRINGi243365.CV_2876

Structurei

3D structure databases

ProteinModelPortaliQ7NU27
SMRiQ7NU27
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni279 – 289Substrate-bindingUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DP5 Bacteria
COG1166 LUCA
HOGENOMiHOG000029191
KOiK01585
OMAiLFPIMPI
OrthoDBiPOG091H04NG

Family and domain databases

CDDicd06830 PLPDE_III_ADC, 1 hit
Gene3Di2.40.37.10, 3 hits
3.20.20.10, 1 hit
HAMAPiMF_01417 SpeA, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR002985 Arg_decrbxlase
IPR022657 De-COase2_CS
IPR022644 De-COase2_N
IPR000183 Orn/DAP/Arg_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR43295 PTHR43295, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PIRSFiPIRSF001336 Arg_decrbxlase, 1 hit
PRINTSiPR01180 ARGDCRBXLASE
PR01179 ODADCRBXLASE
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR01273 speA, 1 hit
PROSITEiView protein in PROSITE
PS00879 ODR_DC_2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7NU27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWSVADSRS LYGIRHWGAG YFDVGDSGNI VVRPNVRQRK EIDLYRLVRD
60 70 80 90 100
LGGKGLDLPL LVRFPDILQD RVTRLCGAFD KAIAEQGYGN RYTAIYPIKV
110 120 130 140 150
NQQEAVVKSI IATQDVSIGL EAGSKPELMA VLALAPKGCT IVCNGYKDRE
160 170 180 190 200
FIRLALIGER LGHQVFIVIE KESEVDLVIE ESRKLEVRPN IGLRVRLSSL
210 220 230 240 250
ASSKWSDTGG EKGKFGLSAG QLISATDKLI AAGLGDCVRL MHFHMGSQIA
260 270 280 290 300
NIADYRLGFR EAIRYFAELR ALGLPVDHVD VGGGLGVDYD GTHSRNDSSI
310 320 330 340 350
NYDMAEYAHV IVSMLSEFCA ENGIPHPRIL SESGRAMTAH HAVLLMNVTD
360 370 380 390 400
VERLPDTVAP IDKAEELSLP LRKLVELANL NDEELVTEIY YRASHCVSEV
410 420 430 440 450
SEMYAEGRLS LQEKALAEDL HATLCRRLHN QLQASQRSQR QVYDELTDRL
460 470 480 490 500
ADKYFCNFSV FQSLPDTWAI DQVLPIMPVH RLAEQPTRRA VLQDLTCDSD
510 520 530 540 550
GKLKQYVDQQ SIESSMSVHE VKQGDEYLIA VFLVGAYQEI LGDMHNLFGD
560 570 580 590 600
TDSVNVYVRE GGELEISGIE EHDTIEDMLR YVHLSPEDLL NRYEAKTREC
610 620
DLNPEERSLY FAEFCRGLKQ SSYLAV
Length:626
Mass (Da):70,119
Last modified:December 15, 2003 - v1
Checksum:i98A2CC60BACFB3F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016825 Genomic DNA Translation: AAQ60544.1
RefSeqiWP_011136423.1, NC_005085.1

Genome annotation databases

EnsemblBacteriaiAAQ60544; AAQ60544; CV_2876
GeneIDi24949145
KEGGicvi:CV_2876

Similar proteinsi

Entry informationi

Entry nameiSPEA_CHRVO
AccessioniPrimary (citable) accession number: Q7NU27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: December 15, 2003
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health