Reviewed, UniProtKB/Swiss-Prot Q7NU27 (SPEA_CHRVO)

Names and origin

Protein names

Recommended name:
    Biosynthetic arginine decarboxylase
      Short name=ADC
    EC=4.1.1.19

Gene names

Name:	speA
Ordered Locus Names:	CV_2876

Organism

Chromobacterium violaceum [Complete proteome] [HAMAP]

Taxonomic identifier

536 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Chromobacterium

Protein attributes

Sequence length	626 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the biosynthesis of agmatine from arginine By similarity.
Catalytic activity	L-arginine = agmatine + CO2. HAMAP MF_01417
Cofactor	Magnesium By similarity. Pyridoxal phosphate By similarity.
Pathway	Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. HAMAP MF_01417
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Ontologies

Keywords
Biological process	Polyamine biosynthesis Putrescine biosynthesis Spermidine biosynthesis
Ligand	Magnesium Metal-binding Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro putrescine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW spermidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 626	626	Biosynthetic arginine decarboxylase HAMAP MF_01417		PRO_0000149958
Regions
	Region	279 – 289	11	Substrate-binding Potential
Amino acid modifications
	Modified residue	99	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7NU27-1 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 98A2CC60BACFB3F3	FASTA	626	70,119
	10 20 30 40 50 60 MAWSVADSRS LYGIRHWGAG YFDVGDSGNI VVRPNVRQRK EIDLYRLVRD LGGKGLDLPL 70 80 90 100 110 120 LVRFPDILQD RVTRLCGAFD KAIAEQGYGN RYTAIYPIKV NQQEAVVKSI IATQDVSIGL 130 140 150 160 170 180 EAGSKPELMA VLALAPKGCT IVCNGYKDRE FIRLALIGER LGHQVFIVIE KESEVDLVIE 190 200 210 220 230 240 ESRKLEVRPN IGLRVRLSSL ASSKWSDTGG EKGKFGLSAG QLISATDKLI AAGLGDCVRL 250 260 270 280 290 300 MHFHMGSQIA NIADYRLGFR EAIRYFAELR ALGLPVDHVD VGGGLGVDYD GTHSRNDSSI 310 320 330 340 350 360 NYDMAEYAHV IVSMLSEFCA ENGIPHPRIL SESGRAMTAH HAVLLMNVTD VERLPDTVAP 370 380 390 400 410 420 IDKAEELSLP LRKLVELANL NDEELVTEIY YRASHCVSEV SEMYAEGRLS LQEKALAEDL 430 440 450 460 470 480 HATLCRRLHN QLQASQRSQR QVYDELTDRL ADKYFCNFSV FQSLPDTWAI DQVLPIMPVH 490 500 510 520 530 540 RLAEQPTRRA VLQDLTCDSD GKLKQYVDQQ SIESSMSVHE VKQGDEYLIA VFLVGAYQEI 550 560 570 580 590 600 LGDMHNLFGD TDSVNVYVRE GGELEISGIE EHDTIEDMLR YVHLSPEDLL NRYEAKTREC 610 620 DLNPEERSLY FAEFCRGLKQ SSYLAV

References

[1]

"The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability." Vasconcelos A.T.R., de Almeida D.F., Hungria M., Guimaraes C.T., Antonio R.V., Almeida F.C., de Almeida L.G.P., de Almeida R., Alves-Gomes J.A., Andrade E.M., Araripe J., de Araujo M.F.F., Astolfi-Filho S., Azevedo V., Baptista A.J., Bataus L.A.M., Batista J.S., Belo A. , van den Berg C., Bogo M., Bonatto S., Bordignon J., Brigido M.M., Brito C.A., Brocchi M., Burity H.A., Camargo A.A., Cardoso D.D.P., Carneiro N.P., Carraro D.M., Carvalho C.M.B., Cascardo J.C.M., Cavada B.S., Chueire L.M.O., Creczynski-Pasa T.B., Cunha-Junior N.C., Fagundes N., Falcao C.L., Fantinatti F., Farias I.P., Felipe M.S.S., Ferrari L.P., Ferro J.A., Ferro M.I.T., Franco G.R., Freitas N.S.A., Furlan L.R., Gazzinelli R.T., Gomes E.A., Goncalves P.R., Grangeiro T.B., Grattapaglia D., Grisard E.C., Hanna E.S., Jardim S.N., Laurino J., Leoi L.C.T., Lima L.F.A., Loureiro M.F., Lyra M.C.C.P., Madeira H.M.F., Manfio G.P., Maranhao A.Q., Martins W.S., di Mauro S.M.Z., de Medeiros S.R.B., Meissner R.V., Moreira M.A.M., Nascimento F.F., Nicolas M.F., Oliveira J.G., Oliveira S.C., Paixao R.F.C., Parente J.A., Pedrosa F.O., Pena S.D.J., Pereira J.O., Pereira M., Pinto L.S.R.C., Pinto L.S., Porto J.I.R., Potrich D.P., Ramalho-Neto C.E., Reis A.M.M., Rigo L.U., Rondinelli E., Santos E.B.P., Santos F.R., Schneider M.P.C., Seuanez H.N., Silva A.M.R., da Silva A.L.C., Silva D.W., Silva R., Simoes I.C., Simon D., Soares C.M.A., Soares R.B.A., Souza E.M., Souza K.R.L., Souza R.C., Steffens M.B.R., Steindel M., Teixeira S.R., Urmenyi T., Vettore A., Wassem R., Zaha A., Simpson A.J.G. Proc. Natl. Acad. Sci. U.S.A. 100:11660-11665(2003) [PubMed: 14500782] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 12472 / DSM 30191 / IFO 12614 / JCM 1249 / NCIB 9131.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016825 Genomic DNA. Translation: AAQ60544.1.
RefSeq	NP_902546.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2548774.
GenomeReviews	Gene locus CV_2876 in contig AE016825_GR.
KEGG	cvi:CV_2876.
NMPDR	fig|243365.1.peg.2876.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7NU27.
OMA	LICNGYK.
Enzyme and pathway databases
BioCyc	CVIO243365:CV_2876-MON.
BRENDA	4.1.1.19. 415.
Family and domain databases
HAMAP	MF_01417. [Tree]
InterPro	IPR002985. Arg_decrbxlase. IPR000183. De-COase2. [Graphical view]
PANTHER	PTHR11482:SF3. Arg_decrbxlase. 1 hit.
Pfam	PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view]
PIRSF	PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTS	PR01180. ARGDCRBXLASE. PR01179. ODADCRBXLASE.
TIGRFAMs	TIGR01273. speA. 1 hit.
PROSITE	PS00878. ODR_DC_2_1. False negative. PS00879. ODR_DC_2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SPEA_CHRVO

Accession

Primary (citable) accession number: Q7NU27

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
Last sequence update:	December 15, 2003
Last modified:	November 3, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)