Reviewed,
UniProtKB/Swiss-Prot Q7NTY1 (GUAC_CHRVO)
Last modified
January 19, 2010.
Version 41.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: GMP reductase EC=1.7.1.7 Alternative name(s): Guanosine 5'-monophosphate oxidoreductase Short name=Guanosine monophosphate reductase | ||||
| Gene names |
| ||||
| Organism | Chromobacterium violaceum [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 536 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Chromobacterium |
Protein attributes
| Sequence length | 316 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. HAMAP MF_01511 |
| Catalytic activity | Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. HAMAP MF_01511 |
| Sequence similarities | Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW purine nucleotide metabolic processInferred from electronic annotation. Source: HAMAP |
| Molecular function | GMP reductase activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 316 | 316 | GMP reductase HAMAP MF_01511 | PRO_0000294271 | |||||
Regions | |||||||||
| Nucleotide binding | 202 – 225 | 24 | NADP Potential | ||||||
Sites | |||||||||
| Active site | 175 | 1 | Thioimidate intermediate By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability." Vasconcelos A.T.R., de Almeida D.F., Hungria M., Guimaraes C.T., Antonio R.V., Almeida F.C., de Almeida L.G.P., de Almeida R., Alves-Gomes J.A., Andrade E.M., Araripe J., de Araujo M.F.F., Astolfi-Filho S., Azevedo V., Baptista A.J., Bataus L.A.M., Batista J.S., Belo A. Simpson A.J.G.Proc. Natl. Acad. Sci. U.S.A. 100:11660-11665(2003) [PubMed: 14500782] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 12472 / DSM 30191 / IFO 12614 / JCM 1249 / NCIB 9131. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE016825 Genomic DNA. Translation: AAQ60590.1. |
| RefSeq | NP_902592.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1YPF based on UniProtKB Q81JJ9. |
| SMR | Q7NTY1. Positions 5-315. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2547468. |
| GenomeReviews | Gene locus CV_2922 in contig AE016825_GR. |
| KEGG | cvi:CV_2922. |
| NMPDR | fig|243365.1.peg.2922. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG298985. |
| OMA | FAGHEES. |
Enzyme and pathway databases | |
| BioCyc | CVIO243365:CV_2922-MONOMER. |
| BRENDA | 1.7.1.7. 415. |
Family and domain databases | |
| HAMAP | MF_01511. GMP_reduct_type2. [Tree] |
| InterPro | IPR013785. Aldolase_TIM. IPR005994. GMP_reduct2. IPR001093. IMP_DH_GMPRt. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| Pfam | PF00478. IMPDH. 1 hit. [Graphical view] |
| PIRSF | PIRSF036500. GMP_red_Firmic. 1 hit. |
| PROSITE | PS00487. IMP_DH_GMP_RED. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GUAC_CHRVO | ||||||||
| Accession | Primary (citable) accession number: Q7NTY1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

Clusters with


