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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciCVIO243365:G1G08-3438-MONOMER
UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:CV_3422
OrganismiChromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Taxonomic identifieri243365 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeChromobacterium
Proteomesi
  • UP000001424 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002058271 – 402Nicotinate phosphoribosyltransferaseAdd BLAST402

Proteomic databases

PRIDEiQ7NSK2

Interactioni

Protein-protein interaction databases

STRINGi243365.CV_3422

Structurei

3D structure databases

ProteinModelPortaliQ7NSK2
SMRiQ7NSK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RH7 Bacteria
COG1488 LUCA
HOGENOMiHOG000284928
KOiK00763
OMAiMGFEIFV
OrthoDBiPOG091H0197

Family and domain databases

CDDicd01401 PncB_like, 1 hit
HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

Q7NSK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKNTPIIRS LLDTDLYKFT MLQVVLHQFP AAHGEYEFRC RNHPDTPLTQ
60 70 80 90 100
LKQQLETQLD LLCELRFSQD ELDYLRGLRF IKSDYVDYLE LFHLQRRFIS
110 120 130 140 150
VSEEGEQLAI RIKGPMVQAM FFEIFVLAIV NELYFRPLDS KAVREEGRRR
160 170 180 190 200
LEAKLAELER FQREEAPGQR FPLLIADFGT RRRFSRDWQA HVVERLNHAL
210 220 230 240 250
PQVFRGTSNV YLARKLGITP IGTMAHEFFQ AFQALGVRLR DFQKAALESW
260 270 280 290 300
VQEYRGDLGI ALTDVVGMDA FLADFDLYFA KLFDGLRHDS GDPYIWGEKA
310 320 330 340 350
IAHYRKLRID PATKMLTFSD GLSVDSALQL QRHFSPHIQV SFGIGTHFTN
360 370 380 390 400
DMGLEPLQIV LKLVSCNGQP VAKLSDSPGK TMCSDETFLA YLRQVFKVPA

LA
Length:402
Mass (Da):46,340
Last modified:December 15, 2003 - v1
Checksum:i99494737859FE6E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016825 Genomic DNA Translation: AAQ61085.1
RefSeqiWP_011136969.1, NC_005085.1

Genome annotation databases

EnsemblBacteriaiAAQ61085; AAQ61085; CV_3422
GeneIDi24946192
KEGGicvi:CV_3422

Similar proteinsi

Entry informationi

Entry nameiPNCB_CHRVO
AccessioniPrimary (citable) accession number: Q7NSK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 15, 2003
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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