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Q7NSJ5 (GCSP_CHRVO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:CV_3429
OrganismChromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757) [Complete proteome] [HAMAP]
Taxonomic identifier243365 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeChromobacterium

Protein attributes

Sequence length950 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 950950Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000166911

Amino acid modifications

Modified residue6991N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7NSJ5 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 21635475A0621C2F

FASTA950102,268
        10         20         30         40         50         60 
MSLTELFNRH EFLARHIGPS DAERAEMLAA VGAPSIDALV DQTLPADIRL NRRLDLPSPQ 

        70         80         90        100        110        120 
PEAEALAALK AVASKNVVNK SFIGLGYYPV LTPTVILRNV LENPGWYTAY TPYQAEIAQG 

       130        140        150        160        170        180 
RLEALLNFQQ MVIDLTGLEM ANASLLDEAT AAAEAMAMAG RVSKSKSTRF FVDSRVLPQT 

       190        200        210        220        230        240 
LDVMKTRAKY FGFELVQGHP EEAGNGDYFG ALFQYPGEAG DLLDLTPHIA AVKAKGGVVA 

       250        260        270        280        290        300 
VAADVMALVA LKSPAEMGAD IALGNTQRFG VPMGFGGPHA AYFAFKDEMK RSAPGRIIGV 

       310        320        330        340        350        360 
SIDAKGKTAL RMALQTREQH IRREKANSNI CTSQVLLANI AGLYAVYHGA EGVRRIAARI 

       370        380        390        400        410        420 
HRLAAIFAHA VKEAGGKLVF DRFFDTVQVD APKADAIYAA ALAAGYNLRR VGKTVLGVAF 

       430        440        450        460        470        480 
HEAATESDLA KLIELFTGKP ADIAALDAAA LDAIPAALKR ESAILTHPVF NTHHSEHEML 

       490        500        510        520        530        540 
RYMKKLENRD LAMNHSMISL GSCTMKLNAT SEMIPITWPE FANMHPFAPR EQTVGYLELI 

       550        560        570        580        590        600 
EGLQKQLKAI TGFDAISMQP NSGAQGEYAG LLAISRYHES RGEAHRNICL IPQSAHGTNP 

       610        620        630        640        650        660 
ATAQMMNMQV VVVKCDEAGN VDVADLKAKA EQHAANLAAL MITYPSTHGV FEQGIKEICE 

       670        680        690        700        710        720 
IVHAHGGQVY MDGANLNAQV GLTRPADIGA DVSHMNLHKT FCIPHGGGGP GMGPIGLKAH 

       730        740        750        760        770        780 
LAPFIANHVV APVPGAVEGQ TAVSAAPFGS ASILPISYMY IAMMGAEGMK QATENALLSA 

       790        800        810        820        830        840 
NYLATRLSEH FPVLYTGANG RVAHECIIDL RPLKAASGVT EVDVAKRLMD YGFHAPTMSF 

       850        860        870        880        890        900 
PVPGTLMIEP TESEPKAELD RFIAAMAAIR AEIDRVQSGA WPADNNPLVN APHSKADIAG 

       910        920        930        940        950 
DWDRPYSREQ GLFPLPYVLE NKFWPSVNRI DDVYGDRNVV CSCPSTESYM 

« Hide

References

[1]"The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability."
Vasconcelos A.T.R., de Almeida D.F., Hungria M., Guimaraes C.T., Antonio R.V., Almeida F.C., de Almeida L.G.P., de Almeida R., Alves-Gomes J.A., Andrade E.M., Araripe J., de Araujo M.F.F., Astolfi-Filho S., Azevedo V., Baptista A.J., Bataus L.A.M., Batista J.S., Belo A. expand/collapse author list , van den Berg C., Bogo M., Bonatto S., Bordignon J., Brigido M.M., Brito C.A., Brocchi M., Burity H.A., Camargo A.A., Cardoso D.D.P., Carneiro N.P., Carraro D.M., Carvalho C.M.B., Cascardo J.C.M., Cavada B.S., Chueire L.M.O., Creczynski-Pasa T.B., Cunha-Junior N.C., Fagundes N., Falcao C.L., Fantinatti F., Farias I.P., Felipe M.S.S., Ferrari L.P., Ferro J.A., Ferro M.I.T., Franco G.R., Freitas N.S.A., Furlan L.R., Gazzinelli R.T., Gomes E.A., Goncalves P.R., Grangeiro T.B., Grattapaglia D., Grisard E.C., Hanna E.S., Jardim S.N., Laurino J., Leoi L.C.T., Lima L.F.A., Loureiro M.F., Lyra M.C.C.P., Madeira H.M.F., Manfio G.P., Maranhao A.Q., Martins W.S., di Mauro S.M.Z., de Medeiros S.R.B., Meissner R.V., Moreira M.A.M., Nascimento F.F., Nicolas M.F., Oliveira J.G., Oliveira S.C., Paixao R.F.C., Parente J.A., Pedrosa F.O., Pena S.D.J., Pereira J.O., Pereira M., Pinto L.S.R.C., Pinto L.S., Porto J.I.R., Potrich D.P., Ramalho-Neto C.E., Reis A.M.M., Rigo L.U., Rondinelli E., Santos E.B.P., Santos F.R., Schneider M.P.C., Seuanez H.N., Silva A.M.R., da Silva A.L.C., Silva D.W., Silva R., Simoes I.C., Simon D., Soares C.M.A., Soares R.B.A., Souza E.M., Souza K.R.L., Souza R.C., Steffens M.B.R., Steindel M., Teixeira S.R., Urmenyi T., Vettore A., Wassem R., Zaha A., Simpson A.J.G.
Proc. Natl. Acad. Sci. U.S.A. 100:11660-11665(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016825 Genomic DNA. Translation: AAQ61092.1.
RefSeqNP_903099.1. NC_005085.1.

3D structure databases

ProteinModelPortalQ7NSJ5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243365.CV_3429.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAQ61092; AAQ61092; CV_3429.
GeneID2548312.
KEGGcvi:CV_3429.
PATRIC21441646. VBIChrVio67196_3352.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAKATEHAI.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycCVIO243365:GHUD-3511-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_CHRVO
AccessionPrimary (citable) accession number: Q7NSJ5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families