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Q7NSJ5

- GCSP_CHRVO

UniProt

Q7NSJ5 - GCSP_CHRVO

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, CV_3429
Organism
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCVIO243365:GHUD-3511-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:CV_3429
OrganismiChromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Taxonomic identifieri243365 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeChromobacterium
ProteomesiUP000001424: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 950950Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_0000166911Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei699 – 6991N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi243365.CV_3429.

Structurei

3D structure databases

ProteinModelPortaliQ7NSJ5.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiKATEHAI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7NSJ5-1 [UniParc]FASTAAdd to Basket

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MSLTELFNRH EFLARHIGPS DAERAEMLAA VGAPSIDALV DQTLPADIRL    50
NRRLDLPSPQ PEAEALAALK AVASKNVVNK SFIGLGYYPV LTPTVILRNV 100
LENPGWYTAY TPYQAEIAQG RLEALLNFQQ MVIDLTGLEM ANASLLDEAT 150
AAAEAMAMAG RVSKSKSTRF FVDSRVLPQT LDVMKTRAKY FGFELVQGHP 200
EEAGNGDYFG ALFQYPGEAG DLLDLTPHIA AVKAKGGVVA VAADVMALVA 250
LKSPAEMGAD IALGNTQRFG VPMGFGGPHA AYFAFKDEMK RSAPGRIIGV 300
SIDAKGKTAL RMALQTREQH IRREKANSNI CTSQVLLANI AGLYAVYHGA 350
EGVRRIAARI HRLAAIFAHA VKEAGGKLVF DRFFDTVQVD APKADAIYAA 400
ALAAGYNLRR VGKTVLGVAF HEAATESDLA KLIELFTGKP ADIAALDAAA 450
LDAIPAALKR ESAILTHPVF NTHHSEHEML RYMKKLENRD LAMNHSMISL 500
GSCTMKLNAT SEMIPITWPE FANMHPFAPR EQTVGYLELI EGLQKQLKAI 550
TGFDAISMQP NSGAQGEYAG LLAISRYHES RGEAHRNICL IPQSAHGTNP 600
ATAQMMNMQV VVVKCDEAGN VDVADLKAKA EQHAANLAAL MITYPSTHGV 650
FEQGIKEICE IVHAHGGQVY MDGANLNAQV GLTRPADIGA DVSHMNLHKT 700
FCIPHGGGGP GMGPIGLKAH LAPFIANHVV APVPGAVEGQ TAVSAAPFGS 750
ASILPISYMY IAMMGAEGMK QATENALLSA NYLATRLSEH FPVLYTGANG 800
RVAHECIIDL RPLKAASGVT EVDVAKRLMD YGFHAPTMSF PVPGTLMIEP 850
TESEPKAELD RFIAAMAAIR AEIDRVQSGA WPADNNPLVN APHSKADIAG 900
DWDRPYSREQ GLFPLPYVLE NKFWPSVNRI DDVYGDRNVV CSCPSTESYM 950
Length:950
Mass (Da):102,268
Last modified:December 15, 2003 - v1
Checksum:i21635475A0621C2F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016825 Genomic DNA. Translation: AAQ61092.1.
RefSeqiNP_903099.1. NC_005085.1.

Genome annotation databases

EnsemblBacteriaiAAQ61092; AAQ61092; CV_3429.
GeneIDi2548312.
KEGGicvi:CV_3429.
PATRICi21441646. VBIChrVio67196_3352.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016825 Genomic DNA. Translation: AAQ61092.1 .
RefSeqi NP_903099.1. NC_005085.1.

3D structure databases

ProteinModelPortali Q7NSJ5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243365.CV_3429.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAQ61092 ; AAQ61092 ; CV_3429 .
GeneIDi 2548312.
KEGGi cvi:CV_3429.
PATRICi 21441646. VBIChrVio67196_3352.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi KATEHAI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci CVIO243365:GHUD-3511-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability."
    Vasconcelos A.T.R., de Almeida D.F., Hungria M., Guimaraes C.T., Antonio R.V., Almeida F.C., de Almeida L.G.P., de Almeida R., Alves-Gomes J.A., Andrade E.M., Araripe J., de Araujo M.F.F., Astolfi-Filho S., Azevedo V., Baptista A.J., Bataus L.A.M., Batista J.S., Belo A.
    , van den Berg C., Bogo M., Bonatto S., Bordignon J., Brigido M.M., Brito C.A., Brocchi M., Burity H.A., Camargo A.A., Cardoso D.D.P., Carneiro N.P., Carraro D.M., Carvalho C.M.B., Cascardo J.C.M., Cavada B.S., Chueire L.M.O., Creczynski-Pasa T.B., Cunha-Junior N.C., Fagundes N., Falcao C.L., Fantinatti F., Farias I.P., Felipe M.S.S., Ferrari L.P., Ferro J.A., Ferro M.I.T., Franco G.R., Freitas N.S.A., Furlan L.R., Gazzinelli R.T., Gomes E.A., Goncalves P.R., Grangeiro T.B., Grattapaglia D., Grisard E.C., Hanna E.S., Jardim S.N., Laurino J., Leoi L.C.T., Lima L.F.A., Loureiro M.F., Lyra M.C.C.P., Madeira H.M.F., Manfio G.P., Maranhao A.Q., Martins W.S., di Mauro S.M.Z., de Medeiros S.R.B., Meissner R.V., Moreira M.A.M., Nascimento F.F., Nicolas M.F., Oliveira J.G., Oliveira S.C., Paixao R.F.C., Parente J.A., Pedrosa F.O., Pena S.D.J., Pereira J.O., Pereira M., Pinto L.S.R.C., Pinto L.S., Porto J.I.R., Potrich D.P., Ramalho-Neto C.E., Reis A.M.M., Rigo L.U., Rondinelli E., Santos E.B.P., Santos F.R., Schneider M.P.C., Seuanez H.N., Silva A.M.R., da Silva A.L.C., Silva D.W., Silva R., Simoes I.C., Simon D., Soares C.M.A., Soares R.B.A., Souza E.M., Souza K.R.L., Souza R.C., Steffens M.B.R., Steindel M., Teixeira S.R., Urmenyi T., Vettore A., Wassem R., Zaha A., Simpson A.J.G.
    Proc. Natl. Acad. Sci. U.S.A. 100:11660-11665(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757.

Entry informationi

Entry nameiGCSP_CHRVO
AccessioniPrimary (citable) accession number: Q7NSJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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