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Q7NSJ5

- GCSP_CHRVO

UniProt

Q7NSJ5 - GCSP_CHRVO

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciCVIO243365:GHUD-3511-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:CV_3429
    OrganismiChromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
    Taxonomic identifieri243365 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeChromobacterium
    ProteomesiUP000001424: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 950950Glycine dehydrogenase (decarboxylating)PRO_0000166911Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei699 – 6991N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi243365.CV_3429.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7NSJ5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiKATEHAI.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7NSJ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLTELFNRH EFLARHIGPS DAERAEMLAA VGAPSIDALV DQTLPADIRL    50
    NRRLDLPSPQ PEAEALAALK AVASKNVVNK SFIGLGYYPV LTPTVILRNV 100
    LENPGWYTAY TPYQAEIAQG RLEALLNFQQ MVIDLTGLEM ANASLLDEAT 150
    AAAEAMAMAG RVSKSKSTRF FVDSRVLPQT LDVMKTRAKY FGFELVQGHP 200
    EEAGNGDYFG ALFQYPGEAG DLLDLTPHIA AVKAKGGVVA VAADVMALVA 250
    LKSPAEMGAD IALGNTQRFG VPMGFGGPHA AYFAFKDEMK RSAPGRIIGV 300
    SIDAKGKTAL RMALQTREQH IRREKANSNI CTSQVLLANI AGLYAVYHGA 350
    EGVRRIAARI HRLAAIFAHA VKEAGGKLVF DRFFDTVQVD APKADAIYAA 400
    ALAAGYNLRR VGKTVLGVAF HEAATESDLA KLIELFTGKP ADIAALDAAA 450
    LDAIPAALKR ESAILTHPVF NTHHSEHEML RYMKKLENRD LAMNHSMISL 500
    GSCTMKLNAT SEMIPITWPE FANMHPFAPR EQTVGYLELI EGLQKQLKAI 550
    TGFDAISMQP NSGAQGEYAG LLAISRYHES RGEAHRNICL IPQSAHGTNP 600
    ATAQMMNMQV VVVKCDEAGN VDVADLKAKA EQHAANLAAL MITYPSTHGV 650
    FEQGIKEICE IVHAHGGQVY MDGANLNAQV GLTRPADIGA DVSHMNLHKT 700
    FCIPHGGGGP GMGPIGLKAH LAPFIANHVV APVPGAVEGQ TAVSAAPFGS 750
    ASILPISYMY IAMMGAEGMK QATENALLSA NYLATRLSEH FPVLYTGANG 800
    RVAHECIIDL RPLKAASGVT EVDVAKRLMD YGFHAPTMSF PVPGTLMIEP 850
    TESEPKAELD RFIAAMAAIR AEIDRVQSGA WPADNNPLVN APHSKADIAG 900
    DWDRPYSREQ GLFPLPYVLE NKFWPSVNRI DDVYGDRNVV CSCPSTESYM 950
    Length:950
    Mass (Da):102,268
    Last modified:December 15, 2003 - v1
    Checksum:i21635475A0621C2F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016825 Genomic DNA. Translation: AAQ61092.1.
    RefSeqiNP_903099.1. NC_005085.1.

    Genome annotation databases

    EnsemblBacteriaiAAQ61092; AAQ61092; CV_3429.
    GeneIDi2548312.
    KEGGicvi:CV_3429.
    PATRICi21441646. VBIChrVio67196_3352.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016825 Genomic DNA. Translation: AAQ61092.1 .
    RefSeqi NP_903099.1. NC_005085.1.

    3D structure databases

    ProteinModelPortali Q7NSJ5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243365.CV_3429.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAQ61092 ; AAQ61092 ; CV_3429 .
    GeneIDi 2548312.
    KEGGi cvi:CV_3429.
    PATRICi 21441646. VBIChrVio67196_3352.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi KATEHAI.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci CVIO243365:GHUD-3511-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability."
      Vasconcelos A.T.R., de Almeida D.F., Hungria M., Guimaraes C.T., Antonio R.V., Almeida F.C., de Almeida L.G.P., de Almeida R., Alves-Gomes J.A., Andrade E.M., Araripe J., de Araujo M.F.F., Astolfi-Filho S., Azevedo V., Baptista A.J., Bataus L.A.M., Batista J.S., Belo A.
      , van den Berg C., Bogo M., Bonatto S., Bordignon J., Brigido M.M., Brito C.A., Brocchi M., Burity H.A., Camargo A.A., Cardoso D.D.P., Carneiro N.P., Carraro D.M., Carvalho C.M.B., Cascardo J.C.M., Cavada B.S., Chueire L.M.O., Creczynski-Pasa T.B., Cunha-Junior N.C., Fagundes N., Falcao C.L., Fantinatti F., Farias I.P., Felipe M.S.S., Ferrari L.P., Ferro J.A., Ferro M.I.T., Franco G.R., Freitas N.S.A., Furlan L.R., Gazzinelli R.T., Gomes E.A., Goncalves P.R., Grangeiro T.B., Grattapaglia D., Grisard E.C., Hanna E.S., Jardim S.N., Laurino J., Leoi L.C.T., Lima L.F.A., Loureiro M.F., Lyra M.C.C.P., Madeira H.M.F., Manfio G.P., Maranhao A.Q., Martins W.S., di Mauro S.M.Z., de Medeiros S.R.B., Meissner R.V., Moreira M.A.M., Nascimento F.F., Nicolas M.F., Oliveira J.G., Oliveira S.C., Paixao R.F.C., Parente J.A., Pedrosa F.O., Pena S.D.J., Pereira J.O., Pereira M., Pinto L.S.R.C., Pinto L.S., Porto J.I.R., Potrich D.P., Ramalho-Neto C.E., Reis A.M.M., Rigo L.U., Rondinelli E., Santos E.B.P., Santos F.R., Schneider M.P.C., Seuanez H.N., Silva A.M.R., da Silva A.L.C., Silva D.W., Silva R., Simoes I.C., Simon D., Soares C.M.A., Soares R.B.A., Souza E.M., Souza K.R.L., Souza R.C., Steffens M.B.R., Steindel M., Teixeira S.R., Urmenyi T., Vettore A., Wassem R., Zaha A., Simpson A.J.G.
      Proc. Natl. Acad. Sci. U.S.A. 100:11660-11665(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757.

    Entry informationi

    Entry nameiGCSP_CHRVO
    AccessioniPrimary (citable) accession number: Q7NSJ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 2, 2004
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3