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Q7NSJ5

- GCSP_CHRVO

UniProt

Q7NSJ5 - GCSP_CHRVO

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCVIO243365:GHUD-3511-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:CV_3429
OrganismiChromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Taxonomic identifieri243365 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeChromobacterium
ProteomesiUP000001424: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 950950Glycine dehydrogenase (decarboxylating)PRO_0000166911Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei699 – 6991N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi243365.CV_3429.

Structurei

3D structure databases

ProteinModelPortaliQ7NSJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiKATEHAI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7NSJ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLTELFNRH EFLARHIGPS DAERAEMLAA VGAPSIDALV DQTLPADIRL
60 70 80 90 100
NRRLDLPSPQ PEAEALAALK AVASKNVVNK SFIGLGYYPV LTPTVILRNV
110 120 130 140 150
LENPGWYTAY TPYQAEIAQG RLEALLNFQQ MVIDLTGLEM ANASLLDEAT
160 170 180 190 200
AAAEAMAMAG RVSKSKSTRF FVDSRVLPQT LDVMKTRAKY FGFELVQGHP
210 220 230 240 250
EEAGNGDYFG ALFQYPGEAG DLLDLTPHIA AVKAKGGVVA VAADVMALVA
260 270 280 290 300
LKSPAEMGAD IALGNTQRFG VPMGFGGPHA AYFAFKDEMK RSAPGRIIGV
310 320 330 340 350
SIDAKGKTAL RMALQTREQH IRREKANSNI CTSQVLLANI AGLYAVYHGA
360 370 380 390 400
EGVRRIAARI HRLAAIFAHA VKEAGGKLVF DRFFDTVQVD APKADAIYAA
410 420 430 440 450
ALAAGYNLRR VGKTVLGVAF HEAATESDLA KLIELFTGKP ADIAALDAAA
460 470 480 490 500
LDAIPAALKR ESAILTHPVF NTHHSEHEML RYMKKLENRD LAMNHSMISL
510 520 530 540 550
GSCTMKLNAT SEMIPITWPE FANMHPFAPR EQTVGYLELI EGLQKQLKAI
560 570 580 590 600
TGFDAISMQP NSGAQGEYAG LLAISRYHES RGEAHRNICL IPQSAHGTNP
610 620 630 640 650
ATAQMMNMQV VVVKCDEAGN VDVADLKAKA EQHAANLAAL MITYPSTHGV
660 670 680 690 700
FEQGIKEICE IVHAHGGQVY MDGANLNAQV GLTRPADIGA DVSHMNLHKT
710 720 730 740 750
FCIPHGGGGP GMGPIGLKAH LAPFIANHVV APVPGAVEGQ TAVSAAPFGS
760 770 780 790 800
ASILPISYMY IAMMGAEGMK QATENALLSA NYLATRLSEH FPVLYTGANG
810 820 830 840 850
RVAHECIIDL RPLKAASGVT EVDVAKRLMD YGFHAPTMSF PVPGTLMIEP
860 870 880 890 900
TESEPKAELD RFIAAMAAIR AEIDRVQSGA WPADNNPLVN APHSKADIAG
910 920 930 940 950
DWDRPYSREQ GLFPLPYVLE NKFWPSVNRI DDVYGDRNVV CSCPSTESYM
Length:950
Mass (Da):102,268
Last modified:December 15, 2003 - v1
Checksum:i21635475A0621C2F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016825 Genomic DNA. Translation: AAQ61092.1.
RefSeqiNP_903099.1. NC_005085.1.

Genome annotation databases

EnsemblBacteriaiAAQ61092; AAQ61092; CV_3429.
GeneIDi2548312.
KEGGicvi:CV_3429.
PATRICi21441646. VBIChrVio67196_3352.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016825 Genomic DNA. Translation: AAQ61092.1 .
RefSeqi NP_903099.1. NC_005085.1.

3D structure databases

ProteinModelPortali Q7NSJ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243365.CV_3429.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAQ61092 ; AAQ61092 ; CV_3429 .
GeneIDi 2548312.
KEGGi cvi:CV_3429.
PATRICi 21441646. VBIChrVio67196_3352.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi KATEHAI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci CVIO243365:GHUD-3511-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability."
    Vasconcelos A.T.R., de Almeida D.F., Hungria M., Guimaraes C.T., Antonio R.V., Almeida F.C., de Almeida L.G.P., de Almeida R., Alves-Gomes J.A., Andrade E.M., Araripe J., de Araujo M.F.F., Astolfi-Filho S., Azevedo V., Baptista A.J., Bataus L.A.M., Batista J.S., Belo A.
    , van den Berg C., Bogo M., Bonatto S., Bordignon J., Brigido M.M., Brito C.A., Brocchi M., Burity H.A., Camargo A.A., Cardoso D.D.P., Carneiro N.P., Carraro D.M., Carvalho C.M.B., Cascardo J.C.M., Cavada B.S., Chueire L.M.O., Creczynski-Pasa T.B., Cunha-Junior N.C., Fagundes N., Falcao C.L., Fantinatti F., Farias I.P., Felipe M.S.S., Ferrari L.P., Ferro J.A., Ferro M.I.T., Franco G.R., Freitas N.S.A., Furlan L.R., Gazzinelli R.T., Gomes E.A., Goncalves P.R., Grangeiro T.B., Grattapaglia D., Grisard E.C., Hanna E.S., Jardim S.N., Laurino J., Leoi L.C.T., Lima L.F.A., Loureiro M.F., Lyra M.C.C.P., Madeira H.M.F., Manfio G.P., Maranhao A.Q., Martins W.S., di Mauro S.M.Z., de Medeiros S.R.B., Meissner R.V., Moreira M.A.M., Nascimento F.F., Nicolas M.F., Oliveira J.G., Oliveira S.C., Paixao R.F.C., Parente J.A., Pedrosa F.O., Pena S.D.J., Pereira J.O., Pereira M., Pinto L.S.R.C., Pinto L.S., Porto J.I.R., Potrich D.P., Ramalho-Neto C.E., Reis A.M.M., Rigo L.U., Rondinelli E., Santos E.B.P., Santos F.R., Schneider M.P.C., Seuanez H.N., Silva A.M.R., da Silva A.L.C., Silva D.W., Silva R., Simoes I.C., Simon D., Soares C.M.A., Soares R.B.A., Souza E.M., Souza K.R.L., Souza R.C., Steffens M.B.R., Steindel M., Teixeira S.R., Urmenyi T., Vettore A., Wassem R., Zaha A., Simpson A.J.G.
    Proc. Natl. Acad. Sci. U.S.A. 100:11660-11665(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757.

Entry informationi

Entry nameiGCSP_CHRVO
AccessioniPrimary (citable) accession number: Q7NSJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: December 15, 2003
Last modified: October 1, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3