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Protein

Probable acetoacetate decarboxylase

Gene

adc

Organism
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of acetoacetate to acetone and carbon dioxide.UniRule annotation

Catalytic activityi

Acetoacetate = acetone + CO2.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei116 – 1161Schiff-base intermediate with acetoacetateUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciCVIO243365:GHUD-3602-MONOMER.
BRENDAi4.1.1.4. 1370.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable acetoacetate decarboxylaseUniRule annotation (EC:4.1.1.4UniRule annotation)
Short name:
AADUniRule annotation
Short name:
ADCUniRule annotation
Gene namesi
Name:adcUniRule annotation
Ordered Locus Names:CV_3520
OrganismiChromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Taxonomic identifieri243365 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeChromobacterium
Proteomesi
  • UP000001424 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Probable acetoacetate decarboxylasePRO_0000207104Add
BLAST

Interactioni

Protein-protein interaction databases

DIPiDIP-59757N.
STRINGi243365.CV_3520.

Structurei

Secondary structure

1
246
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 97Combined sources
Beta strandi11 – 144Combined sources
Beta strandi25 – 3814Combined sources
Helixi41 – 455Combined sources
Beta strandi52 – 543Combined sources
Beta strandi56 – 6914Combined sources
Turni70 – 723Combined sources
Beta strandi73 – 8614Combined sources
Beta strandi89 – 10012Combined sources
Helixi102 – 1109Combined sources
Beta strandi116 – 1183Combined sources
Beta strandi120 – 1267Combined sources
Beta strandi129 – 1368Combined sources
Beta strandi139 – 14911Combined sources
Helixi155 – 1639Combined sources
Beta strandi166 – 1738Combined sources
Beta strandi177 – 18711Combined sources
Beta strandi189 – 19911Combined sources
Beta strandi202 – 2065Combined sources
Helixi214 – 2163Combined sources
Beta strandi220 – 23415Combined sources
Beta strandi238 – 2425Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BGTX-ray2.10A/B/C/D1-246[»]
3BH3X-ray2.10A/B/C/D1-246[»]
ProteinModelPortaliQ7NSA6.
SMRiQ7NSA6. Positions 3-245.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7NSA6.

Family & Domainsi

Sequence similaritiesi

Belongs to the ADC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107GD3. Bacteria.
COG4689. LUCA.
HOGENOMiHOG000063822.
KOiK01574.
OMAiPGPYRFV.
OrthoDBiPOG091H0QG4.

Family and domain databases

Gene3Di2.40.400.10. 1 hit.
HAMAPiMF_00597. ADC. 1 hit.
InterProiIPR010451. Acetoacetate_decarboxylase.
IPR023653. Acetoacetate_decarboxylase_bac.
IPR023375. Acetoacetate_decarboxylase_dom.
[Graphical view]
PfamiPF06314. ADC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7NSA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQQEVRQRA FAMPLTSPAF PPGPYRFVNR EYMIITYRTD PAAIEAVLPE
60 70 80 90 100
PLQMAEPVVR YEFIRMPDST GFGDYSESGQ VIPVTFRGER GSYTLAMFLD
110 120 130 140 150
DQPPLAGGRE LWGFPKKAGK PRLEVHQDTL VGSLDFGPVR IATGTMGYKY
160 170 180 190 200
EALDRSALLA SLAEPNFLLK IIPHVDGSPR ICELVRYHTT DVAIKGAWSA
210 220 230 240
PGSLELHPHA LAPVAALPVL EVLSARHFVC DLTLDLGTVV FDYLRQ
Length:246
Mass (Da):27,299
Last modified:December 15, 2003 - v1
Checksum:i3596958D9583E3E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016825 Genomic DNA. Translation: AAQ61181.1.
RefSeqiWP_011137067.1. NC_005085.1.

Genome annotation databases

EnsemblBacteriaiAAQ61181; AAQ61181; CV_3520.
GeneIDi24946939.
KEGGicvi:CV_3520.
PATRICi21441835. VBIChrVio67196_3446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016825 Genomic DNA. Translation: AAQ61181.1.
RefSeqiWP_011137067.1. NC_005085.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BGTX-ray2.10A/B/C/D1-246[»]
3BH3X-ray2.10A/B/C/D1-246[»]
ProteinModelPortaliQ7NSA6.
SMRiQ7NSA6. Positions 3-245.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59757N.
STRINGi243365.CV_3520.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAQ61181; AAQ61181; CV_3520.
GeneIDi24946939.
KEGGicvi:CV_3520.
PATRICi21441835. VBIChrVio67196_3446.

Phylogenomic databases

eggNOGiENOG4107GD3. Bacteria.
COG4689. LUCA.
HOGENOMiHOG000063822.
KOiK01574.
OMAiPGPYRFV.
OrthoDBiPOG091H0QG4.

Enzyme and pathway databases

BioCyciCVIO243365:GHUD-3602-MONOMER.
BRENDAi4.1.1.4. 1370.

Miscellaneous databases

EvolutionaryTraceiQ7NSA6.
PROiQ7NSA6.

Family and domain databases

Gene3Di2.40.400.10. 1 hit.
HAMAPiMF_00597. ADC. 1 hit.
InterProiIPR010451. Acetoacetate_decarboxylase.
IPR023653. Acetoacetate_decarboxylase_bac.
IPR023375. Acetoacetate_decarboxylase_dom.
[Graphical view]
PfamiPF06314. ADC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADC_CHRVO
AccessioniPrimary (citable) accession number: Q7NSA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: December 15, 2003
Last modified: September 7, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.