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Protein

Probable acetoacetate decarboxylase

Gene

adc

Organism
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of acetoacetate to acetone and carbon dioxide.UniRule annotation

Catalytic activityi

Acetoacetate = acetone + CO2.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei116Schiff-base intermediate with acetoacetateUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BRENDAi4.1.1.4. 1370.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable acetoacetate decarboxylaseUniRule annotation (EC:4.1.1.4UniRule annotation)
Short name:
AADUniRule annotation
Short name:
ADCUniRule annotation
Gene namesi
Name:adcUniRule annotation
Ordered Locus Names:CV_3520
OrganismiChromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Taxonomic identifieri243365 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeChromobacterium
Proteomesi
  • UP000001424 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002071041 – 246Probable acetoacetate decarboxylaseAdd BLAST246

Interactioni

Protein-protein interaction databases

DIPiDIP-59757N.
STRINGi243365.CV_3520.

Structurei

Secondary structure

1246
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 9Combined sources7
Beta strandi11 – 14Combined sources4
Beta strandi25 – 38Combined sources14
Helixi41 – 45Combined sources5
Beta strandi52 – 54Combined sources3
Beta strandi56 – 69Combined sources14
Turni70 – 72Combined sources3
Beta strandi73 – 86Combined sources14
Beta strandi89 – 100Combined sources12
Helixi102 – 110Combined sources9
Beta strandi116 – 118Combined sources3
Beta strandi120 – 126Combined sources7
Beta strandi129 – 136Combined sources8
Beta strandi139 – 149Combined sources11
Helixi155 – 163Combined sources9
Beta strandi166 – 173Combined sources8
Beta strandi177 – 187Combined sources11
Beta strandi189 – 199Combined sources11
Beta strandi202 – 206Combined sources5
Helixi214 – 216Combined sources3
Beta strandi220 – 234Combined sources15
Beta strandi238 – 242Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BGTX-ray2.10A/B/C/D1-246[»]
3BH3X-ray2.10A/B/C/D1-246[»]
ProteinModelPortaliQ7NSA6.
SMRiQ7NSA6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7NSA6.

Family & Domainsi

Sequence similaritiesi

Belongs to the ADC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107GD3. Bacteria.
COG4689. LUCA.
HOGENOMiHOG000063822.
KOiK01574.
OMAiPGPYRFV.
OrthoDBiPOG091H0QG4.

Family and domain databases

Gene3Di2.40.400.10. 1 hit.
HAMAPiMF_00597. ADC. 1 hit.
InterProiIPR010451. Acetoacetate_decarboxylase.
IPR023653. Acetoacetate_decarboxylase_bac.
IPR023375. Acetoacetate_decarboxylase_dom.
[Graphical view]
PfamiPF06314. ADC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7NSA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQQEVRQRA FAMPLTSPAF PPGPYRFVNR EYMIITYRTD PAAIEAVLPE
60 70 80 90 100
PLQMAEPVVR YEFIRMPDST GFGDYSESGQ VIPVTFRGER GSYTLAMFLD
110 120 130 140 150
DQPPLAGGRE LWGFPKKAGK PRLEVHQDTL VGSLDFGPVR IATGTMGYKY
160 170 180 190 200
EALDRSALLA SLAEPNFLLK IIPHVDGSPR ICELVRYHTT DVAIKGAWSA
210 220 230 240
PGSLELHPHA LAPVAALPVL EVLSARHFVC DLTLDLGTVV FDYLRQ
Length:246
Mass (Da):27,299
Last modified:December 15, 2003 - v1
Checksum:i3596958D9583E3E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016825 Genomic DNA. Translation: AAQ61181.1.
RefSeqiWP_011137067.1. NC_005085.1.

Genome annotation databases

EnsemblBacteriaiAAQ61181; AAQ61181; CV_3520.
GeneIDi24946939.
KEGGicvi:CV_3520.
PATRICi21441835. VBIChrVio67196_3446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016825 Genomic DNA. Translation: AAQ61181.1.
RefSeqiWP_011137067.1. NC_005085.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BGTX-ray2.10A/B/C/D1-246[»]
3BH3X-ray2.10A/B/C/D1-246[»]
ProteinModelPortaliQ7NSA6.
SMRiQ7NSA6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59757N.
STRINGi243365.CV_3520.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAQ61181; AAQ61181; CV_3520.
GeneIDi24946939.
KEGGicvi:CV_3520.
PATRICi21441835. VBIChrVio67196_3446.

Phylogenomic databases

eggNOGiENOG4107GD3. Bacteria.
COG4689. LUCA.
HOGENOMiHOG000063822.
KOiK01574.
OMAiPGPYRFV.
OrthoDBiPOG091H0QG4.

Enzyme and pathway databases

BRENDAi4.1.1.4. 1370.

Miscellaneous databases

EvolutionaryTraceiQ7NSA6.
PROiQ7NSA6.

Family and domain databases

Gene3Di2.40.400.10. 1 hit.
HAMAPiMF_00597. ADC. 1 hit.
InterProiIPR010451. Acetoacetate_decarboxylase.
IPR023653. Acetoacetate_decarboxylase_bac.
IPR023375. Acetoacetate_decarboxylase_dom.
[Graphical view]
PfamiPF06314. ADC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADC_CHRVO
AccessioniPrimary (citable) accession number: Q7NSA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: December 15, 2003
Last modified: November 2, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.