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Q7NS23 (METE_CHRVO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

EC=2.1.1.14
Alternative name(s):
Cobalamin-independent methionine synthase
Methionine synthase, vitamin-B12 independent isozyme
Gene names
Name:metE
Ordered Locus Names:CV_3604
OrganismChromobacterium violaceum [Complete proteome] [HAMAP]
Taxonomic identifier536 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeChromobacterium

Protein attributes

Sequence length760 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. HAMAP MF_00172

Catalytic activity

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP MF_00172

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00172

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP MF_00172

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7607605-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP MF_00172
PRO_0000098625

Sites

Metal binding6431Zinc By similarity
Metal binding6451Zinc By similarity
Metal binding7281Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7NS23 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 3B4E621C52B06B6C

FASTA76083,581
        10         20         30         40         50         60 
MSHATHLLGF PRIGAKRELK TLLERYWKQE LDEAALSQGA KELRQKHWLL QKGAGVELSP 

        70         80         90        100        110        120 
VGDFSLYDHV LDAQLLVGAA PARFGFDAAA LTTGQYFELA RGNAVQPAME MTKWFDTNYH 

       130        140        150        160        170        180 
YLVPEWHADT AFSAQPERLL SQLREARALG VAAKPVLLGP LSLLWLGKAK GRPFDRLALL 

       190        200        210        220        230        240 
PGLVAAYREL LSSLRAAGAE WAQIDEPILA LDLEPSWLDA FAPAYAQLSR HAPKLLLATY 

       250        260        270        280        290        300 
FGDVSEHAAR LKSLPVAGLH LDLVRAPEQI SAFLPDYPAD KVLSAGIVDG RNIWRADLSA 

       310        320        330        340        350        360 
LLDRLAPLAQ QLGDRLWLAP SCSLLHSPFD AAAETGLDPE LKNWLAFAVQ KLNELKTLKR 

       370        380        390        400        410        420 
GLEHGRSAIA GELSGSDFAR EQRRASPRIH DPAVARRLAA LPEGTDRRAS PYPIRAERQQ 

       430        440        450        460        470        480 
AWLKLPPLPT TTIGSFPQTP AIRASRAAFK KGELSAAGYR QAMEKEIELA IRRQEALGLD 

       490        500        510        520        530        540 
VLVHGEAERN DMVEYFGEQL AGFAFTAGGW VQSYGSRCVK PPIIFGDVAR PKPMTVDWAR 

       550        560        570        580        590        600 
YAQSLTAKPV KGMLTGPVTI LQWSFVRDDL PRREVCRQIA LALNDEVLDL EAAGIRVIQI 

       610        620        630        640        650        660 
DEPAIREGLP LKRAGRDVYL AWAGEAFRLS SRGVDDATQI HTHMCYSEFG DILPAIAALD 

       670        680        690        700        710        720 
ADVITIETSR SDMALLADFG RFRYPNAIGP GVYDIHSPRV PSAAEIRALL DKALRVIPAE 

       730        740        750        760 
RLWVNPDCGL KTRGWPEVEA ALAAMVAVGR ELREKLAQAA 

« Hide

References

[1]"The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability."
Vasconcelos A.T.R., de Almeida D.F., Hungria M., Guimaraes C.T., Antonio R.V., Almeida F.C., de Almeida L.G.P., de Almeida R., Alves-Gomes J.A., Andrade E.M., Araripe J., de Araujo M.F.F., Astolfi-Filho S., Azevedo V., Baptista A.J., Bataus L.A.M., Batista J.S., Belo A. expand/collapse author list , van den Berg C., Bogo M., Bonatto S., Bordignon J., Brigido M.M., Brito C.A., Brocchi M., Burity H.A., Camargo A.A., Cardoso D.D.P., Carneiro N.P., Carraro D.M., Carvalho C.M.B., Cascardo J.C.M., Cavada B.S., Chueire L.M.O., Creczynski-Pasa T.B., Cunha-Junior N.C., Fagundes N., Falcao C.L., Fantinatti F., Farias I.P., Felipe M.S.S., Ferrari L.P., Ferro J.A., Ferro M.I.T., Franco G.R., Freitas N.S.A., Furlan L.R., Gazzinelli R.T., Gomes E.A., Goncalves P.R., Grangeiro T.B., Grattapaglia D., Grisard E.C., Hanna E.S., Jardim S.N., Laurino J., Leoi L.C.T., Lima L.F.A., Loureiro M.F., Lyra M.C.C.P., Madeira H.M.F., Manfio G.P., Maranhao A.Q., Martins W.S., di Mauro S.M.Z., de Medeiros S.R.B., Meissner R.V., Moreira M.A.M., Nascimento F.F., Nicolas M.F., Oliveira J.G., Oliveira S.C., Paixao R.F.C., Parente J.A., Pedrosa F.O., Pena S.D.J., Pereira J.O., Pereira M., Pinto L.S.R.C., Pinto L.S., Porto J.I.R., Potrich D.P., Ramalho-Neto C.E., Reis A.M.M., Rigo L.U., Rondinelli E., Santos E.B.P., Santos F.R., Schneider M.P.C., Seuanez H.N., Silva A.M.R., da Silva A.L.C., Silva D.W., Silva R., Simoes I.C., Simon D., Soares C.M.A., Soares R.B.A., Souza E.M., Souza K.R.L., Souza R.C., Steffens M.B.R., Steindel M., Teixeira S.R., Urmenyi T., Vettore A., Wassem R., Zaha A., Simpson A.J.G.
Proc. Natl. Acad. Sci. U.S.A. 100:11660-11665(2003) [PubMed: 14500782] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016825 Genomic DNA. Translation: AAQ61266.1.
RefSeqNP_903274.1. NC_005085.1.

3D structure databases

ProteinModelPortalQ7NS23.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2548455.
GenomeReviewsGene locus CV_3604 in contig AE016825_GR.
KEGGcvi:CV_3604.
NMPDRfig|243365.1.peg.3604.
PATRIC21442029. VBIChrVio67196_3530.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG287495.
OMARNIWRAN.
PhylomeDBQ7NS23.
ProtClustDBPRK05222.

Enzyme and pathway databases

BioCycCVIO243365:CV_3604-MONOMER.

Family and domain databases

HAMAPMF_00172. Meth_synth.
[Tree]
InterProIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Methionine_synth.
[Graphical view]
KOK00549.
PfamPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsTIGR01371. Met_syn_B12ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMETE_CHRVO
AccessionPrimary (citable) accession number: Q7NS23
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: December 15, 2003
Last modified: January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families