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Protein

Thymidine phosphorylase

Gene

deoA

Organism
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.UniRule annotation

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: dTMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes dTMP from thymine.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Thymidine phosphorylase (deoA)
  2. no protein annotated in this organism
This subpathway is part of the pathway dTMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dTMP from thymine, the pathway dTMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciCVIO243365:G1G08-3725-MONOMER
UniPathwayiUPA00578; UER00638

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine phosphorylaseUniRule annotation (EC:2.4.2.4UniRule annotation)
Alternative name(s):
TdRPaseUniRule annotation
Gene namesi
Name:deoAUniRule annotation
Ordered Locus Names:CV_3700
OrganismiChromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Taxonomic identifieri243365 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeChromobacterium
Proteomesi
  • UP000001424 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000590511 – 441Thymidine phosphorylaseAdd BLAST441

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi243365.CV_3700

Structurei

3D structure databases

ProteinModelPortaliQ7NRT0
SMRiQ7NRT0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMW Bacteria
COG0213 LUCA
HOGENOMiHOG000047313
KOiK00758
OMAiVHSIGGV
OrthoDBiPOG091H02BC

Family and domain databases

Gene3Di3.40.1030.10, 2 hits
3.90.1170.30, 1 hit
HAMAPiMF_01628 Thymid_phosp, 1 hit
InterProiView protein in InterPro
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR018090 Pyrmidine_PPas_bac/euk
IPR017872 Pyrmidine_PPase_CS
IPR000053 Thymidine/pyrmidine_PPase
IPR013465 Thymidine_Pase
PANTHERiPTHR10515 PTHR10515, 1 hit
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit
PIRSFiPIRSF000478 TP_PyNP, 1 hit
SMARTiView protein in SMART
SM00941 PYNP_C, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
SSF54680 SSF54680, 1 hit
TIGRFAMsiTIGR02643 T_phosphoryl, 1 hit
TIGR02644 Y_phosphoryl, 1 hit
PROSITEiView protein in PROSITE
PS00647 THYMID_PHOSPHORYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q7NRT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLPQEIIRK KRDNLTLSQQ EIQQFVAGIT DNSVADSQIA ALAMAIYFNG
60 70 80 90 100
MELEENVHLA LAMRDSGRRM HWKDLNLPGP IVDKHSTGGV GDVVSLMLGP
110 120 130 140 150
MVAACGGFVP MISGRGLGHT GGTLDKLSAV PGYNPFPEPE LFRKVVKDVG
160 170 180 190 200
VAIIGQTSDL APADRRFYAT RDVTATVESI ALITASILSK KLAAGLDVLV
210 220 230 240 250
MDVKAGSGAF MPTMQKSIEL AERIVKVGNG AGVATTALIT EMSQPLASTA
260 270 280 290 300
GNSIETREAV RYLKGDQRNP RLHEVTMALC AQMLIGGKLA ADEADARAKL
310 320 330 340 350
QAALDSGRAA EIFGRMVTAL GGPADFMEHY DRHLAPAPIM RPVYADRAGY
360 370 380 390 400
VGAMDTRGIG MAVCALGGGR RLATDVLDFR VGLSQFVELG QNIGKDTPLM
410 420 430 440
MIHAADEASF EDAARRVKAA IRIDEAAPSE LPLVYQIIRG E
Length:441
Mass (Da):47,055
Last modified:December 15, 2003 - v1
Checksum:iAB836251BC332CB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016825 Genomic DNA Translation: AAQ61362.1
RefSeqiWP_011137247.1, NC_005085.1

Genome annotation databases

EnsemblBacteriaiAAQ61362; AAQ61362; CV_3700
GeneIDi24948396
KEGGicvi:CV_3700

Similar proteinsi

Entry informationi

Entry nameiTYPH_CHRVO
AccessioniPrimary (citable) accession number: Q7NRT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: December 15, 2003
Last modified: June 20, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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