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Protein

Deoxyribose-phosphate aldolase

Gene

deoC

Organism
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.UniRule annotation

Catalytic activityi

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.UniRule annotation

Pathwayi: 2-deoxy-D-ribose 1-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Deoxyribose-phosphate aldolase (deoC)
This subpathway is part of the pathway 2-deoxy-D-ribose 1-phosphate degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate, the pathway 2-deoxy-D-ribose 1-phosphate degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei165 – 1651Schiff-base intermediate with acetaldehydeUniRule annotation
Active sitei197 – 1971UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciCVIO243365:GHUD-3796-MONOMER.
UniPathwayiUPA00002; UER00468.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribose-phosphate aldolaseUniRule annotation (EC:4.1.2.4UniRule annotation)
Short name:
DERAUniRule annotation
Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolaseUniRule annotation
PhosphodeoxyriboaldolaseUniRule annotation
Short name:
DeoxyriboaldolaseUniRule annotation
Gene namesi
Name:deoCUniRule annotation
Ordered Locus Names:CV_3701
OrganismiChromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Taxonomic identifieri243365 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeChromobacterium
Proteomesi
  • UP000001424 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255Deoxyribose-phosphate aldolasePRO_0000057295Add
BLAST

Proteomic databases

PRIDEiQ7NRS9.

Interactioni

Protein-protein interaction databases

STRINGi243365.CV_3701.

Structurei

3D structure databases

ProteinModelPortaliQ7NRS9.
SMRiQ7NRS9. Positions 1-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105FCI. Bacteria.
COG0274. LUCA.
HOGENOMiHOG000241644.
KOiK01619.
OMAiCIWPRFV.
OrthoDBiPOG091H00TV.

Family and domain databases

CDDicd00959. DeoC. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00592. DeoC_type2. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR023649. DeoC_typeII.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00126. deoC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7NRS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALIEAARR ALSLMDLTTL NDDDTDEKVA ALCRKAKSPD GTVAAVCVFP
60 70 80 90 100
RFVPIAKKTL REAGCPEVQV ATVTNFPHGN DDVSIAVAET RAAIAYGADE
110 120 130 140 150
VDVVFPYRAL MAGNRDIGFE LVKACKEACG GKLLKVIIES GELKDAALIR
160 170 180 190 200
EASEISIRAG ADFIKTSTGK VPVNATLPAA ETMLAVIKEQ GGQCGFKAAG
210 220 230 240 250
GVKSATEAAE YLALAARLLG EDWVSARHFR FGASSLLANL QIEIAGGVAK

PSSGY
Length:255
Mass (Da):26,702
Last modified:December 15, 2003 - v1
Checksum:iAD686DE7752802A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016825 Genomic DNA. Translation: AAQ61363.1.
RefSeqiWP_011137248.1. NC_005085.1.

Genome annotation databases

EnsemblBacteriaiAAQ61363; AAQ61363; CV_3701.
GeneIDi24949066.
KEGGicvi:CV_3701.
PATRICi21442229. VBIChrVio67196_3630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016825 Genomic DNA. Translation: AAQ61363.1.
RefSeqiWP_011137248.1. NC_005085.1.

3D structure databases

ProteinModelPortaliQ7NRS9.
SMRiQ7NRS9. Positions 1-232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243365.CV_3701.

Proteomic databases

PRIDEiQ7NRS9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAQ61363; AAQ61363; CV_3701.
GeneIDi24949066.
KEGGicvi:CV_3701.
PATRICi21442229. VBIChrVio67196_3630.

Phylogenomic databases

eggNOGiENOG4105FCI. Bacteria.
COG0274. LUCA.
HOGENOMiHOG000241644.
KOiK01619.
OMAiCIWPRFV.
OrthoDBiPOG091H00TV.

Enzyme and pathway databases

UniPathwayiUPA00002; UER00468.
BioCyciCVIO243365:GHUD-3796-MONOMER.

Family and domain databases

CDDicd00959. DeoC. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00592. DeoC_type2. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR023649. DeoC_typeII.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00126. deoC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDEOC_CHRVO
AccessioniPrimary (citable) accession number: Q7NRS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: September 7, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.