Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q7NQS9 (KPRS_CHRVO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribose-phosphate pyrophosphokinase
Short name=RPPK
EC=2.7.6.1
Alternative name(s):
Phosphoribosyl pyrophosphate synthase
Short name=P-Rib-PP synthase
Short name=PRPP synthase
Gene names
Name:prs
Synonyms:prsA
Ordered Locus Names:CV_4058
OrganismChromobacterium violaceum [Complete proteome] [HAMAP]
Taxonomic identifier536 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Chromobacterium

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00583_B

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP MF_00583_B

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP MF_00583_B

Subcellular location

Cytoplasm By similarity HAMAP MF_00583_B.

Sequence similarities

Belongs to the ribose-phosphate pyrophosphokinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 327327Ribose-phosphate pyrophosphokinase HAMAP MF_00583_B
PRO_0000141125

Regions

Region215 – 22814Binding of phosphoribosylpyrophosphate Potential

Sites

Metal binding1321Magnesium Potential
Metal binding1341Magnesium Potential
Metal binding1431Magnesium Potential
Metal binding1471Magnesium Potential

Sequences

Sequence LengthMass (Da)Tools
Q7NQS9 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 4A202E62FEEF3374

FASTA32735,195
        10         20         30         40         50         60 
MAAYDSLMVF TGTANPELAQ NVVKHLDISL GRADVGKFSD GEVAVELLEN VRGRDVFILQ 

        70         80         90        100        110        120 
STCAPTNDNL MEILTMADAL KRASAGRITA AIPYFGYARQ DRRPRSARVP ISAKLVANML 

       130        140        150        160        170        180 
TSAGIDRVLT VDLHADQIQG FFDIPVDNVY ATPVLLKDIR AQRFDDLIVV SPDVGGVVRA 

       190        200        210        220        230        240 
RAVAKALNTD LAIIDKRRPK ANVAEVMNII GDVSGRTCLI VDDMIDTANT LCKAASALKE 

       250        260        270        280        290        300 
RGAERVLAYA THAIFSGQAV DRIKNSDIDM VVVTDTIPLT AAAKACPNIR VASIAGLLAE 

       310        320 
TLRRINNEES VSYLFNEELV ATGACLP

« Hide

References

[1]"The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability."
Vasconcelos A.T.R., de Almeida D.F., Hungria M., Guimaraes C.T., Antonio R.V., Almeida F.C., de Almeida L.G.P., de Almeida R., Alves-Gomes J.A., Andrade E.M., Araripe J., de Araujo M.F.F., Astolfi-Filho S., Azevedo V., Baptista A.J., Bataus L.A.M., Batista J.S., Belo A. expand/collapse author list , van den Berg C., Bogo M., Bonatto S., Bordignon J., Brigido M.M., Brito C.A., Brocchi M., Burity H.A., Camargo A.A., Cardoso D.D.P., Carneiro N.P., Carraro D.M., Carvalho C.M.B., Cascardo J.C.M., Cavada B.S., Chueire L.M.O., Creczynski-Pasa T.B., Cunha-Junior N.C., Fagundes N., Falcao C.L., Fantinatti F., Farias I.P., Felipe M.S.S., Ferrari L.P., Ferro J.A., Ferro M.I.T., Franco G.R., Freitas N.S.A., Furlan L.R., Gazzinelli R.T., Gomes E.A., Goncalves P.R., Grangeiro T.B., Grattapaglia D., Grisard E.C., Hanna E.S., Jardim S.N., Laurino J., Leoi L.C.T., Lima L.F.A., Loureiro M.F., Lyra M.C.C.P., Madeira H.M.F., Manfio G.P., Maranhao A.Q., Martins W.S., di Mauro S.M.Z., de Medeiros S.R.B., Meissner R.V., Moreira M.A.M., Nascimento F.F., Nicolas M.F., Oliveira J.G., Oliveira S.C., Paixao R.F.C., Parente J.A., Pedrosa F.O., Pena S.D.J., Pereira J.O., Pereira M., Pinto L.S.R.C., Pinto L.S., Porto J.I.R., Potrich D.P., Ramalho-Neto C.E., Reis A.M.M., Rigo L.U., Rondinelli E., Santos E.B.P., Santos F.R., Schneider M.P.C., Seuanez H.N., Silva A.M.R., da Silva A.L.C., Silva D.W., Silva R., Simoes I.C., Simon D., Soares C.M.A., Soares R.B.A., Souza E.M., Souza K.R.L., Souza R.C., Steffens M.B.R., Steindel M., Teixeira S.R., Urmenyi T., Vettore A., Wassem R., Zaha A., Simpson A.J.G.
Proc. Natl. Acad. Sci. U.S.A. 100:11660-11665(2003) [PubMed: 14500782] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016825 Genomic DNA. Translation: AAQ61718.1.
RefSeqNP_903728.1. NC_005085.1.

3D structure databases

ProteinModelPortalQ7NQS9.
SMRQ7NQS9. Positions 7-311.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2550095.
GenomeReviewsGene locus CV_4058 in contig AE016825_GR.
KEGGcvi:CV_4058.
NMPDRfig|243365.1.peg.4058.
PATRIC21442923. VBIChrVio67196_3970.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG519284.
OMATDTIPLT.
PhylomeDBQ7NQS9.
ProtClustDBPRK01259.

Enzyme and pathway databases

BioCycCVIO243365:CV_4058-MONOMER.

Family and domain databases

HAMAPMF_00583_B. RibP_PPkinase_B.
[Tree]
InterProIPR000842. PRib_PP_synth_CS.
IPR000836. PRibTrfase.
IPR005946. Rib-P_diPkinase.
[Graphical view]
KOK00948.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR01251. RibP_PPkin. 1 hit.
PROSITEPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPRS_CHRVO
AccessionPrimary (citable) accession number: Q7NQS9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 15, 2003
Last modified: January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents