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Reviewed, UniProtKB/Swiss-Prot Q7NQS0 (APAH_CHRVO)

Last modified June 16, 2009. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
    EC=3.6.1.41
Alternative name(s):
    Diadenosine tetraphosphatase
    Ap4A hydrolase
    Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Gene names
Name: apaH
Ordered Locus Names: CV_4067
OrganismChromobacterium violaceum [Complete proteome] [HAMAP]
Taxonomic identifier536 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Chromobacterium

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Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity.

Catalytic activity

P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP MF_00199

Sequence similarities

Belongs to the Ap4A hydrolase family.

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Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionbis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 277277Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP MF_00199
PRO_0000197986

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Sequences

Sequence LengthMass (Da)Tools
Q7NQS0-1 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: DA95697A48FF8A5F

FASTA27731,193
        10         20         30         40         50         60 
MAIYAIGDIQ GCFEPFQQLL RLIDFNPGKD TLWLTGDLVN RGPQSLEVLR WVFQHQDQVE 

        70         80         90        100        110        120 
MVLGNHDLHL LAVSEGFGKI HRDDTIDDVL NAADGKVLLD WLRCQPMMLE GHGYAMVHAG 

       130        140        150        160        170        180 
LLPEWTISKA LRLAEEVEFG LSGTRYREFL GRLYGNKPTR WTDDLKGVDR LRLIVNVMTR 

       190        200        210        220        230        240 
MRFLTRDGEL DLSYKGELEG APANLVPWFE APNRRHGGTP IVCGHWSALG VHLDEDILAI 

       250        260        270 
DSGCLWGGSL SALRLDDKQL FSLPCQAYRE IALATGR

« Hide

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References

[1]"The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability."
Vasconcelos A.T.R., de Almeida D.F., Hungria M., Guimaraes C.T., Antonio R.V., Almeida F.C., de Almeida L.G.P., de Almeida R., Alves-Gomes J.A., Andrade E.M., Araripe J., de Araujo M.F.F., Astolfi-Filho S., Azevedo V., Baptista A.J., Bataus L.A.M., Batista J.S., Belo A. expand/collapse author list , van den Berg C., Bogo M., Bonatto S., Bordignon J., Brigido M.M., Brito C.A., Brocchi M., Burity H.A., Camargo A.A., Cardoso D.D.P., Carneiro N.P., Carraro D.M., Carvalho C.M.B., Cascardo J.C.M., Cavada B.S., Chueire L.M.O., Creczynski-Pasa T.B., Cunha-Junior N.C., Fagundes N., Falcao C.L., Fantinatti F., Farias I.P., Felipe M.S.S., Ferrari L.P., Ferro J.A., Ferro M.I.T., Franco G.R., Freitas N.S.A., Furlan L.R., Gazzinelli R.T., Gomes E.A., Goncalves P.R., Grangeiro T.B., Grattapaglia D., Grisard E.C., Hanna E.S., Jardim S.N., Laurino J., Leoi L.C.T., Lima L.F.A., Loureiro M.F., Lyra M.C.C.P., Madeira H.M.F., Manfio G.P., Maranhao A.Q., Martins W.S., di Mauro S.M.Z., de Medeiros S.R.B., Meissner R.V., Moreira M.A.M., Nascimento F.F., Nicolas M.F., Oliveira J.G., Oliveira S.C., Paixao R.F.C., Parente J.A., Pedrosa F.O., Pena S.D.J., Pereira J.O., Pereira M., Pinto L.S.R.C., Pinto L.S., Porto J.I.R., Potrich D.P., Ramalho-Neto C.E., Reis A.M.M., Rigo L.U., Rondinelli E., Santos E.B.P., Santos F.R., Schneider M.P.C., Seuanez H.N., Silva A.M.R., da Silva A.L.C., Silva D.W., Silva R., Simoes I.C., Simon D., Soares C.M.A., Soares R.B.A., Souza E.M., Souza K.R.L., Souza R.C., Steffens M.B.R., Steindel M., Teixeira S.R., Urmenyi T., Vettore A., Wassem R., Zaha A., Simpson A.J.G.
Proc. Natl. Acad. Sci. U.S.A. 100:11660-11665(2003) [PubMed: 14500782] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 12472 / DSM 30191 / IFO 12614 / JCM 1249 / NCIB 9131.

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Cross-references

Sequence databases

AE016825 Genomic DNA. Translation: AAQ61727.1.
RefSeqNP_903737.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID2550938.
GenomeReviewsGene locus CV_4067 in contig AE016825_GR.
KEGGcvi:CV_4067.
NMPDRfig|243365.1.peg.4067.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ7NQS0.
OMAQ7NQS0. LVFGHWA.

Enzyme and pathway databases

BioCycCVIO243365:CV_4067-MON.
BRENDA3.6.1.41. 415.

Family and domain databases

HAMAPMF_00199.
[Tree]
InterProIPR004617. ApaH.
IPR004843. M-pesterase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFPIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMsTIGR00668. apaH. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameAPAH_CHRVO
AccessionPrimary (citable) accession number: Q7NQS0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: December 15, 2003
Last modified: June 16, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents