Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciCVIO243365:G1G08-4302-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:CV_4264
OrganismiChromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Taxonomic identifieri243365 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeChromobacterium
Proteomesi
  • UP000001424 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000829481 – 307Methionyl-tRNA formyltransferaseAdd BLAST307

Interactioni

Protein-protein interaction databases

STRINGi243365.CV_4264

Structurei

3D structure databases

ProteinModelPortaliQ7NQ76
SMRiQ7NQ76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 113Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
IPR001555 GART_AS
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit
PROSITEiView protein in PROSITE
PS00373 GART, 1 hit

Sequencei

Sequence statusi: Complete.

Q7NQ76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLIFAGTPE FAAAALRELI AAGHEIALVL TQPDRPAGRG MKLKPSPVKE
60 70 80 90 100
VALAHGLRVE QPEKLRGNQE AQQMLRDIQA DVMVVAAYGL ILPQDVLDIP
110 120 130 140 150
ARGCLNIHAS LLPRWRGAAP IQRAILAGDD ETGITIMQMD VGLDTGDMLS
160 170 180 190 200
IHPVAIAADE TAATLHDKLA ACGAQAIVET LGRLDRIVPR KQPEDGVTYA
210 220 230 240 250
QKLSKAEAEV DWALPAEQVA RAIRAYNPAP GAFTQLGGEP LKLWMASAEP
260 270 280 290 300
GSAEPGAVVS ADADGVLVGA GQGLVRVSVL QAAGGKRLAA RDFVAGKSLP

AGTRLGV
Length:307
Mass (Da):32,115
Last modified:December 15, 2003 - v1
Checksum:i225B6AF71FE1EE26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016825 Genomic DNA Translation: AAQ61924.1
RefSeqiWP_011137810.1, NC_005085.1

Genome annotation databases

EnsemblBacteriaiAAQ61924; AAQ61924; CV_4264
GeneIDi24946646
KEGGicvi:CV_4264

Similar proteinsi

Entry informationi

Entry nameiFMT_CHRVO
AccessioniPrimary (citable) accession number: Q7NQ76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health