Reviewed,
UniProtKB/Swiss-Prot Q7NQ65 (GSHB_CHRVO)
Last modified
June 16, 2009.
Version 38.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Glutathione synthetase EC=6.3.2.3 Alternative name(s): Glutathione synthase GSH synthetase Short name=GSH-S Short name=GSHase | ||||
| Gene names |
| ||||
| Organism | Chromobacterium violaceum [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 536 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Chromobacterium |
Protein attributes
| Sequence length | 314 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione. HAMAP MF_00162 |
| Cofactor | Binds 1 magnesium or manganese ion per subunit By similarity. |
| Pathway | Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2. HAMAP MF_00162 |
| Sequence similarities | Belongs to the prokaryotic GSH synthase family. Contains 1 ATP-grasp domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glutathione biosynthesis |
| Ligand | ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | glutathione biosynthetic process Inferred from electronic annotation. Source: HAMAP |
| Molecular function | ATP binding Inferred from electronic annotation. Source: HAMAP glutathione synthase activityInferred from electronic annotation. Source: HAMAP magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW manganese ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 314 | 314 | Glutathione synthetase HAMAP MF_00162 | PRO_0000197463 | |||||
Regions | |||||||||
| Domain | 122 – 309 | 188 | ATP-grasp | ||||||
| Nucleotide binding | 149 – 206 | 58 | ATP By similarity | ||||||
Sites | |||||||||
| Metal binding | 280 | 1 | Magnesium or manganese By similarity | ||||||
| Metal binding | 282 | 1 | Magnesium or manganese By similarity | ||||||
Sequences
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References
| [1] | "The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability." Vasconcelos A.T.R., de Almeida D.F., Hungria M., Guimaraes C.T., Antonio R.V., Almeida F.C., de Almeida L.G.P., de Almeida R., Alves-Gomes J.A., Andrade E.M., Araripe J., de Araujo M.F.F., Astolfi-Filho S., Azevedo V., Baptista A.J., Bataus L.A.M., Batista J.S., Belo A. Simpson A.J.G.Proc. Natl. Acad. Sci. U.S.A. 100:11660-11665(2003) [PubMed: 14500782] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 12472 / DSM 30191 / IFO 12614 / JCM 1249 / NCIB 9131. |
Cross-references
Sequence databases | |
|---|---|
| AE016825 Genomic DNA. Translation: AAQ61935.1. | |
| RefSeq | NP_903945.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2548852. |
| GenomeReviews | Gene locus CV_4275 in contig AE016825_GR. |
| KEGG | cvi:CV_4275. |
| NMPDR | fig|243365.1.peg.4275. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q7NQ65. |
| OMA | Q7NQ65. VRNAPEK. |
Enzyme and pathway databases | |
| BioCyc | CVIO243365:CV_4275-MON. |
| BRENDA | 6.3.2.3. 415. |
Family and domain databases | |
| HAMAP | MF_00162. [Tree] |
| InterPro | IPR011761. ATP-grasp. IPR013816. ATP_grasp_subdomain_2. IPR006284. Glut_synth_pro. IPR004218. GSHS_ATP_bd. IPR004215. GSHS_N. IPR013817. Pre-ATP_grasp. [Graphical view] |
| Gene3D | G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit. G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit. |
| Pfam | PF02955. GSH-S_ATP. 1 hit. PF02951. GSH-S_N. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01380. glut_syn. 1 hit. |
| PROSITE | PS50975. ATP_GRASP. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GSHB_CHRVO | ||||||||
| Accession | Primary (citable) accession number: Q7NQ65 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


