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Q7NPI4

- GSA_GLOVI

UniProt

Q7NPI4 - GSA_GLOVI

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. chlorophyll biosynthetic process Source: UniProtKB-HAMAP
    2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Chlorophyll biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciGVIO251221:GH9A-71-MONOMER.
    UniPathwayiUPA00251; UER00317.
    UPA00668.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:glr0071
    OrganismiGloeobacter violaceus (strain PCC 7421)
    Taxonomic identifieri251221 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
    ProteomesiUP000000557: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 432432Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000243577Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei272 – 2721N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi251221.gvip005.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7NPI4.
    SMRiQ7NPI4. Positions 6-432.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    KOiK01845.
    OMAiRAIKPYP.
    OrthoDBiEOG6QVRHN.
    PhylomeDBiQ7NPI4.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7NPI4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVTSAFQTAQ SHRLFAEAQQ LMPGGVNSPV RAFKSVGSEP VFIERAEGAY    50
    LWDVDGNRYI EYINTWGPSI VGHSHPEVIS ALREALPKGT SYGAPTRLEN 100
    QMARTVIDAI PAVEMVRFVN SGTEATMSAL RLARAFTGRE KIIKFEGCYH 150
    GHADMLLVQA GSGVATLGLP DSPGVPKSTT AATLTAPYND LAAVEALFKQ 200
    YPSDVAGLIL EPVVGNAGCL VPEIGFLEGL RDLTHAHGTV LIFDEVMTGF 250
    RLSYGGAQAR YGIEPDLTCL GKIIGGGLPV GAYAGRREIM QMVAPAGPMY 300
    QAGTLSGNPL AMTAGIKTLE ILQRPGTYER LEGLSARLAD GLLAAAREAG 350
    HAATGNRVGA MFTLFFTEGP VRNFADAKRS DLQKFARFHR GMLERGVYLA 400
    PSQFEAGFMS LAHTEEDIDY TVAAARTVLA AL 432
    Length:432
    Mass (Da):46,111
    Last modified:December 15, 2003 - v1
    Checksum:i6428A842926FD3D7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000045 Genomic DNA. Translation: BAC88012.1.
    RefSeqiNP_923017.1. NC_005125.1.
    WP_011140075.1. NC_005125.1.

    Genome annotation databases

    EnsemblBacteriaiBAC88012; BAC88012; BAC88012.
    GeneIDi2600048.
    KEGGigvi:gvip005.
    PATRICi22039491. VBIGloVio86258_0074.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000045 Genomic DNA. Translation: BAC88012.1 .
    RefSeqi NP_923017.1. NC_005125.1.
    WP_011140075.1. NC_005125.1.

    3D structure databases

    ProteinModelPortali Q7NPI4.
    SMRi Q7NPI4. Positions 6-432.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 251221.gvip005.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC88012 ; BAC88012 ; BAC88012 .
    GeneIDi 2600048.
    KEGGi gvi:gvip005.
    PATRICi 22039491. VBIGloVio86258_0074.

    Phylogenomic databases

    eggNOGi COG0001.
    KOi K01845.
    OMAi RAIKPYP.
    OrthoDBi EOG6QVRHN.
    PhylomeDBi Q7NPI4.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    UPA00668 .
    BioCyci GVIO251221:GH9A-71-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7421.

    Entry informationi

    Entry nameiGSA_GLOVI
    AccessioniPrimary (citable) accession number: Q7NPI4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3