Q7NP98 (Q7NP98_GLOVI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123

Alternative name(s):
Acetate--CoA ligase HAMAP MF_01123
Acyl-activating enzyme HAMAP MF_01123

Gene names

Name:	acsA HAMAP MF_01123
Ordered Locus Names:	gll0159

Organism

Gloeobacter violaceus (strain PCC 7421)

Taxonomic identifier

251221 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Gloeobacteria › Gloeobacterales › Gloeobacter

Protein attributes

Sequence length	647 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_01123 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01123
PTM	Acetylation HAMAP MF_01123
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	521	1	By similarity HAMAP MF_01123
Amino acid modifications
	Modified residue	613	1	N6-acetyllysine By similarity HAMAP MF_01123

Sequences

	Sequence		Length	Mass (Da)
	Q7NP98 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 6F6780820B1E49AD	FASTA	647	72,082
	10 20 30 40 50 60 MSSFEIESLL HENRRFAPPA GFGEGAWIKS LEHYRELCAR AEADPEGFWA DLARSELHWF 70 80 90 100 110 120 TPWQQVLDWQ EPTARWFVGG KLNLAYNCLD RHLQTRGDKV AVLWEGEPGE VRALTYRELH 130 140 150 160 170 180 AEVCRFANAL KALGVGKGDV VAIYMPLVPE AAVAMLGCAR IGAPHTVVFG GFSGDALRDR 190 200 210 220 230 240 LIDAQARVVV TADGGWRKGA IVPLKPRVDE AVAQAPGVAH VICLKRVGQE VAMEPGRDHW 250 260 270 280 290 300 WHELVASRSA ECPAEAMDSE DLLFILYTSG TTGKPKGVVH TTGGYNLYTH ITSKWIFDLH 310 320 330 340 350 360 DEDVYWCTAD VGWITGHSYV VYGPLSNGAT TFMFEGAPNQ PDPGRFWQLI EKHRIGIFYT 370 380 390 400 410 420 APTAIRTFIK WGDDWPARYD LSSLRLLGTV GEPINPEAWM WYHRVIGQER CPIVDTWWQT 430 440 450 460 470 480 ETGGIMITPL PGATITKPGS ATMPFPGIVA DVVDREGNSC PPNQGGYLVI RRPWPSMLRT 490 500 510 520 530 540 VYRDPERYRQ NYWSQVPHAY FAGDGARRDE EGYFWVMGRV DDVINVSGHR LGTMEIESAL 550 560 570 580 590 600 VSHPAVAEAA VVGRPDEIKG EAIVAFVTVE SEVETTPQLL EELRAHVVKE IGALARPEEI 610 620 630 640 RYAEALPKTR SGKIMRRLLR SLASGSDLTG DTSTLEDRSV LEKLREG

References

[1]

"Complete genome structure of Gloeobacter violaceus PCC 7421, a cyanobacterium that lacks thylakoids." Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T., Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M., Tabata S. DNA Res. 10:137-145(2003) [PubMed: 14621292] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7421.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000045 Genomic DNA. Translation: BAC88100.1.
RefSeq	NP_923105.1. NC_005125.1.
3D structure databases
ProteinModelPortal	Q7NP98.
SMR	Q7NP98. Positions 15-646.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2599944.
GenomeReviews	Gene locus gll0159 in contig BA000045_GR.
KEGG	gvi:gll0159.
NMPDR	fig|251221.1.peg.159.
PATRIC	22039661. VBIGloVio86258_0159.
Phylogenomic databases
HOGENOM	HBG547964.
OMA	VISVSGH.
PhylomeDB	Q7NP98.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q7NP98_GLOVI

Accession

Primary (citable) accession number: Q7NP98

Entry history

Integrated into UniProtKB/TrEMBL:	December 15, 2003
Last sequence update:	December 15, 2003
Last modified:	December 14, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)