Q7NP63 (DXS_GLOVI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7

Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	gll0194

Organism

Gloeobacter violaceus (strain PCC 7421)

Taxonomic identifier

251221 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Gloeobacteria › Gloeobacterales › Gloeobacter

Protein attributes

Sequence length	638 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity. HAMAP MF_00315
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 638	638	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_0000189115

Sequences

	Sequence		Length	Mass (Da)
	Q7NP63 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 8F98EF3AB8211F2E	FASTA	638	68,802
	10 20 30 40 50 60 MNLSDLSHPN QLRDLSVSQL GRLAQQIRDK HLQTVAATGG HLGPGLGVVE LTLALYKTLD 70 80 90 100 110 120 LDRDRVVWDV GHQAYPHKML TGRYANFHTL RQKDGLAGYL KRAESPFDCW GAGHASTSIS 130 140 150 160 170 180 AALGMALARD FQGLNRKVVA IIGDGALTGG MALEALNHAG HLSKTNLMVI LNDNEMSISE 190 200 210 220 230 240 NVGGLSLYLN RLRTDPALRQ IRSNLETQLR NIPLVGPTFS PEFERFKDTV KYMTMTRSKA 250 260 270 280 290 300 GVIFEELGFT YLGPIDGHNL GDLIETFEFA HSLPGPVFLH AITVKGKGYE VAEQNQIKYH 310 320 330 340 350 360 AQSAFDLATG KAKPASKPTP PAYTSVFAQT LVKLAEQNEK IVGITAAMPT GTGLDKFKER 370 380 390 400 410 420 FADRYFDVGI AEQHAVTMAA GLAADGMRPV AAIYSTFLQR AFDQIIHDVA IQDLPVFFCL 430 440 450 460 470 480 DRAGVVGEDG PTHHGVFDLA YLRQIPGLVV MAPKDEAELQ RMMVTGIQYT KGPIAVRYPR 490 500 510 520 530 540 GSGSGAPLMA EGWDPVPIGK AEVLRSGDDL LIVAIGTMVH PSLQAAALLS EHGIDATVVN 550 560 570 580 590 600 ARFAKPLDTE LLLPLARRIG RVVTVEEGCR MGGFGSAVLE ALMDGGIAVP TLRIGIDDKF 610 620 630 VTHAGRSQLL DLLGLTPSGI AKTIRESLST EPVSAPRA

References

[1]

"Complete genome structure of Gloeobacter violaceus PCC 7421, a cyanobacterium that lacks thylakoids." Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T., Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M., Tabata S. DNA Res. 10:137-145(2003) [PubMed: 14621292] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7421.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000045 Genomic DNA. Translation: BAC88135.1.
RefSeq	NP_923140.1. NC_005125.1.
3D structure databases
ProteinModelPortal	Q7NP63.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2599979.
GenomeReviews	Gene locus gll0194 in contig BA000045_GR.
KEGG	gvi:gll0194.
NMPDR	fig|251221.1.peg.194.
PATRIC	22039737. VBIGloVio86258_0195.
Phylogenomic databases
HOGENOM	HBG571647.
OMA	RAHEFES.
PhylomeDB	Q7NP63.
ProtClustDB	PRK05444.
Enzyme and pathway databases
BioCyc	GVIO251221:GLL0194-MONOMER.
Family and domain databases
HAMAP	MF_00315. DXP_synth. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR020826. Transketolase_BS. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K01662.
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. PF00456. Transketolase_N. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00204. Dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_GLOVI

Accession

Primary (citable) accession number: Q7NP63

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	December 15, 2003
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program