Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q7NNW1 (DDL_GLOVI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:gll0297
OrganismGloeobacter violaceus (strain PCC 7421) [Reference proteome] [HAMAP]
Taxonomic identifier251221 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter

Protein attributes

Sequence length302 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 302302D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000177825

Regions

Domain99 – 298200ATP-grasp
Nucleotide binding128 – 18356ATP By similarity

Sites

Metal binding2521Magnesium or manganese 1 By similarity
Metal binding2651Magnesium or manganese 1 By similarity
Metal binding2651Magnesium or manganese 2 By similarity
Metal binding2671Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7NNW1 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: BF8B16064F5A733A

FASTA30232,020
        10         20         30         40         50         60 
MRITVLSGSD SPEREVSLVS GRAVQAALET LGHEVTMVDP GPDLPVRLLE NPPDFVWIAL 

        70         80         90        100        110        120 
HGDKGENGKL QGLLDWLGLP YNGSGVTASA IAMDKVVSKR LFVAEGIPTP AYRVAEAVPQ 

       130        140        150        160        170        180 
VSECQAWLAA LGSPVVVKPA DGGSTVGVTI AREAGHLPEA VRLALQYSPQ VLIEQYIPGQ 

       190        200        210        220        230        240 
EITVALLDGL VLPAIEIVPQ GRDFYDYEAK YAPGGSRHLI PPNLAADVLK ASVDAAYRAC 

       250        260        270        280        290        300 
RAVGSTGLVR ADVRVDPEGR PWVLEVNTLP GMTATSLAPE AAQAAGIDFE QLIQRIIDRS 


LD 

« Hide

References

[1]"Complete genome structure of Gloeobacter violaceus PCC 7421, a cyanobacterium that lacks thylakoids."
Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T., Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M., Tabata S.
DNA Res. 10:137-145(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7421.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000045 Genomic DNA. Translation: BAC88238.1.
RefSeqNP_923243.1. NC_005125.1.

3D structure databases

ProteinModelPortalQ7NNW1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING251221.gll0297.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC88238; BAC88238; BAC88238.
GeneID2599893.
KEGGgvi:gll0297.
PATRIC22039945. VBIGloVio86258_0298.

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMAANDTQYR.
OrthoDBEOG6ND0KB.
PhylomeDBQ7NNW1.

Enzyme and pathway databases

BioCycGVIO251221:GH9A-300-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_GLOVI
AccessionPrimary (citable) accession number: Q7NNW1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways