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Q7NND8

- NADK1_GLOVI

UniProt

Q7NND8 - NADK1_GLOVI

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Protein

NAD kinase 1

Gene

nadK1

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei68 – 681Proton acceptorUniRule annotation
Binding sitei156 – 1561NADUniRule annotation
Binding sitei175 – 1751NADUniRule annotation
Binding sitei177 – 1771NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 692NADUniRule annotation
Nucleotide bindingi145 – 1462NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-476-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 1UniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinase 1UniRule annotation
Gene namesi
Name:nadK1UniRule annotation
Ordered Locus Names:gll0473
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
ProteomesiUP000000557: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310NAD kinase 1PRO_0000229641Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi251221.gll0473.

Structurei

3D structure databases

ProteinModelPortaliQ7NND8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
InParanoidiQ7NND8.
KOiK00858.
OMAiKLHWAGS.
OrthoDBiEOG6PZXDR.
PhylomeDBiQ7NND8.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7NND8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPAFETVVIA YRAEEAHSRI AADRCESLLH KVGCRVLKGP TGPQDNPYPH
60 70 80 90 100
FLEATGGHID LAIVLGGDGS ILAAARYLAA VDVPILAVNV GGHLGFLTQP
110 120 130 140 150
PEVLGGRYWE RLLAGEWELE KRMMLQASLT GPPPLPERQP YFCLNEFCLK
160 170 180 190 200
PASEMRLTSI ILELAIDGEI IDQIHGDGLL VSTPTGSTSY TVAANGPIIA
210 220 230 240 250
PSLQAITITP ICPLSLSSRP VVLPATGTIE VSPLRDPDLN IKLWSDGAFA
260 270 280 290 300
APVHPCQTVR IEVARHPTRL LILEEDHSYF RTLREKLKWA GTRIQAERDP
310
ECLLPPQNHP
Length:310
Mass (Da):33,780
Last modified:December 15, 2003 - v1
Checksum:iBE85CFDD100E021C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC88414.1.
RefSeqiNP_923419.1. NC_005125.1.
WP_011140476.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC88414; BAC88414; BAC88414.
GeneIDi2599674.
KEGGigvi:gll0473.
PATRICi22040311. VBIGloVio86258_0481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC88414.1 .
RefSeqi NP_923419.1. NC_005125.1.
WP_011140476.1. NC_005125.1.

3D structure databases

ProteinModelPortali Q7NND8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 251221.gll0473.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC88414 ; BAC88414 ; BAC88414 .
GeneIDi 2599674.
KEGGi gvi:gll0473.
PATRICi 22040311. VBIGloVio86258_0481.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
InParanoidi Q7NND8.
KOi K00858.
OMAi KLHWAGS.
OrthoDBi EOG6PZXDR.
PhylomeDBi Q7NND8.

Enzyme and pathway databases

BioCyci GVIO251221:GH9A-476-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7421.

Entry informationi

Entry nameiNADK1_GLOVI
AccessioniPrimary (citable) accession number: Q7NND8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 15, 2003
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3