Q7NMP5 (PUR5_GLOVI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase
EC=6.3.3.1

Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase

Gene names

Name:	purM
Ordered Locus Names:	gll0720

Organism

Gloeobacter violaceus (strain PCC 7421) [Reference proteome] [HAMAP]

Taxonomic identifier

251221 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Gloeobacteria › Gloeobacterales › Gloeobacter › Gloeobacter violaceus

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP-Rule MF_00741
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP-Rule MF_00741
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the AIR synthase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP-Rule MF_00741		PRO_0000148214

Sequences

	Sequence		Length	Mass (Da)
	Q7NMP5 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 35EF194D0C4E0B26	FASTA	337	35,366
	10 20 30 40 50 60 MDYKSAGVDV EAGYEFVARI RGAVERTRRP EQLGGLGGFG GLFALPAGYR EPVLVAGTDG 70 80 90 100 110 120 VGTKLKLAFA LDRHDTIGID CVAMCVNDVL AQGAEPLFFL DYLATGKLSP AQLAGVVEGI 130 140 150 160 170 180 AAGCLEAGCT LLGGETAEMP GFYAAGEYDV AGFCVGIVER SQIIDGNRVQ VGDALLGLSS 190 200 210 220 230 240 SGVHSNGFSL VRRIVELAGL DWHHRPEDFP ASLGEVLLTP TRIYVKPVRA ALEAGFDIRG 250 260 270 280 290 300 IAHITGGGLI ENVPRALGGL GACLERNSWP VPPVFTWLER TGGVGRQDMD QTFNLGLGLV 310 320 330 LACPTEQADA LQAYLAKQGE QVLRIGAVVE AAGVRFA

References

[1]

"Complete genome structure of Gloeobacter violaceus PCC 7421, a cyanobacterium that lacks thylakoids." Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T., Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M., Tabata S. DNA Res. 10:137-145(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7421.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000045 Genomic DNA. Translation: BAC88661.1.
RefSeq	NP_923666.1. NC_005125.1.
3D structure databases
ProteinModelPortal	Q7NMP5.
SMR	Q7NMP5. Positions 1-333.
ModBase	Search...
Protein-protein interaction databases
STRING	251221.gvip076.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAC88661; BAC88661; BAC88661.
GeneID	2599439.
KEGG	gvi:gvip076.
PATRIC	22040823. VBIGloVio86258_0733.
Phylogenomic databases
eggNOG	COG0150.
KO	K01933.
OMA	IDMIAMN.
ProtClustDB	PRK05385.
Enzyme and pathway databases
BioCyc	GVIO251221:GH9A-772-MONOMER.
UniPathway	UPA00074; UER00129.
Family and domain databases
HAMAP	MF_00741_B. AIRS_B.
InterPro	IPR010918. AIR_synth_C_dom. IPR000728. AIR_synth_N_dom. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00878. purM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_GLOVI

Accession

Primary (citable) accession number: Q7NMP5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	December 15, 2003
Last modified:	May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program