Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG), ATP phosphoribosyltransferase regulatory subunit (hisZ)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei130NADUniRule annotation1
Binding sitei192NADUniRule annotation1
Binding sitei215NADUniRule annotation1
Binding sitei238SubstrateUniRule annotation1
Metal bindingi260ZincUniRule annotation1
Binding sitei260SubstrateUniRule annotation1
Metal bindingi263ZincUniRule annotation1
Binding sitei263SubstrateUniRule annotation1
Active sitei328Proton acceptorUniRule annotation1
Active sitei329Proton acceptorUniRule annotation1
Binding sitei329SubstrateUniRule annotation1
Metal bindingi362ZincUniRule annotation1
Binding sitei362SubstrateUniRule annotation1
Binding sitei416SubstrateUniRule annotation1
Metal bindingi421ZincUniRule annotation1
Binding sitei421SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:gll1324
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacteraceaeGloeobacter
Proteomesi
  • UP000000557 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001357751 – 445Histidinol dehydrogenaseAdd BLAST445

Interactioni

Protein-protein interaction databases

STRINGi251221.gvip194.

Structurei

3D structure databases

ProteinModelPortaliQ7NL02.
SMRiQ7NL02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CEK. Bacteria.
COG0141. LUCA.
InParanoidiQ7NL02.
KOiK00013.
OMAiGGTARFY.
OrthoDBiPOG091H03YX.
PhylomeDBiQ7NL02.

Family and domain databases

CDDicd06572. Histidinol_dh. 1 hit.
HAMAPiMF_01024. HisD. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7NL02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLITQLSE AQTEIKRIAA RTHSEQVQHQ EATVREILQN VRRQGDEALL
60 70 80 90 100
RYTLEFDQVR LAPGDLVVGA AELDAAYQRV STSLLKAIRL AKQRIEQFHR
110 120 130 140 150
ERICKSWVQF QDRGIVLGRR YTPVDAAGLY IPGGRASYPS SVLMSAIPAV
160 170 180 190 200
VAGVPRIVLV TPPNPEGKIN PAVLVAAQES GVHEIYRIGG AQAIGALTYG
210 220 230 240 250
TRTIAPVSVI AGPGNIYVTL AKKLVYGEVG IDSLAGPSEV LIIADSTANP
260 270 280 290 300
VFLAADMLAQ AEHDSLASAI LITPDGRLAE RTIEAVDRQL ENHPRRTLTE
310 320 330 340 350
KSLANYGLVI VTADLAEAAA LSNLFAPEHL ELEVEDPWEL LEKVRHAGAI
360 370 380 390 400
FLGHATPEAV GDYLAGPSHI LPTSGTARYA SGVGVETFQK CSSLVQYTPQ
410 420 430 440
ALAEVGEAID ALTAAEGLPS HGDSVRLRLQ QYENPHSPTQ QQQEE
Length:445
Mass (Da):48,032
Last modified:December 15, 2003 - v1
Checksum:iE74D1ABE35BBFDC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA. Translation: BAC89265.1.
RefSeqiNP_924270.1. NC_005125.1.
WP_011141324.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC89265; BAC89265; BAC89265.
GeneIDi2598786.
KEGGigvi:gvip194.
PATRICi22042073. VBIGloVio86258_1351.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA. Translation: BAC89265.1.
RefSeqiNP_924270.1. NC_005125.1.
WP_011141324.1. NC_005125.1.

3D structure databases

ProteinModelPortaliQ7NL02.
SMRiQ7NL02.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi251221.gvip194.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC89265; BAC89265; BAC89265.
GeneIDi2598786.
KEGGigvi:gvip194.
PATRICi22042073. VBIGloVio86258_1351.

Phylogenomic databases

eggNOGiENOG4105CEK. Bacteria.
COG0141. LUCA.
InParanoidiQ7NL02.
KOiK00013.
OMAiGGTARFY.
OrthoDBiPOG091H03YX.
PhylomeDBiQ7NL02.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Family and domain databases

CDDicd06572. Histidinol_dh. 1 hit.
HAMAPiMF_01024. HisD. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHISX_GLOVI
AccessioniPrimary (citable) accession number: Q7NL02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 15, 2003
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.