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Q7NL02

- HISX_GLOVI

UniProt

Q7NL02 - HISX_GLOVI

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Protein
Histidinol dehydrogenase
Gene
hisD, gll1324
Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei130 – 1301NAD By similarity
Binding sitei192 – 1921NAD By similarity
Binding sitei215 – 2151NAD By similarity
Binding sitei238 – 2381Substrate By similarity
Metal bindingi260 – 2601Zinc By similarity
Binding sitei260 – 2601Substrate By similarity
Metal bindingi263 – 2631Zinc By similarity
Binding sitei263 – 2631Substrate By similarity
Active sitei328 – 3281Proton acceptor By similarity
Active sitei329 – 3291Proton acceptor By similarity
Binding sitei329 – 3291Substrate By similarity
Metal bindingi362 – 3621Zinc By similarity
Binding sitei362 – 3621Substrate By similarity
Binding sitei416 – 4161Substrate By similarity
Metal bindingi421 – 4211Zinc By similarity
Binding sitei421 – 4211Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-1338-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:gll1324
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
ProteomesiUP000000557: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Histidinol dehydrogenaseUniRule annotation
PRO_0000135775Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi251221.gvip194.

Structurei

3D structure databases

ProteinModelPortaliQ7NL02.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.
PhylomeDBiQ7NL02.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7NL02-1 [UniParc]FASTAAdd to Basket

« Hide

MLRLITQLSE AQTEIKRIAA RTHSEQVQHQ EATVREILQN VRRQGDEALL    50
RYTLEFDQVR LAPGDLVVGA AELDAAYQRV STSLLKAIRL AKQRIEQFHR 100
ERICKSWVQF QDRGIVLGRR YTPVDAAGLY IPGGRASYPS SVLMSAIPAV 150
VAGVPRIVLV TPPNPEGKIN PAVLVAAQES GVHEIYRIGG AQAIGALTYG 200
TRTIAPVSVI AGPGNIYVTL AKKLVYGEVG IDSLAGPSEV LIIADSTANP 250
VFLAADMLAQ AEHDSLASAI LITPDGRLAE RTIEAVDRQL ENHPRRTLTE 300
KSLANYGLVI VTADLAEAAA LSNLFAPEHL ELEVEDPWEL LEKVRHAGAI 350
FLGHATPEAV GDYLAGPSHI LPTSGTARYA SGVGVETFQK CSSLVQYTPQ 400
ALAEVGEAID ALTAAEGLPS HGDSVRLRLQ QYENPHSPTQ QQQEE 445
Length:445
Mass (Da):48,032
Last modified:December 15, 2003 - v1
Checksum:iE74D1ABE35BBFDC7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC89265.1.
RefSeqiNP_924270.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC89265; BAC89265; BAC89265.
GeneIDi2598786.
KEGGigvi:gvip194.
PATRICi22042073. VBIGloVio86258_1351.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC89265.1 .
RefSeqi NP_924270.1. NC_005125.1.

3D structure databases

ProteinModelPortali Q7NL02.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 251221.gvip194.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC89265 ; BAC89265 ; BAC89265 .
GeneIDi 2598786.
KEGGi gvi:gvip194.
PATRICi 22042073. VBIGloVio86258_1351.

Phylogenomic databases

eggNOGi COG0141.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.
PhylomeDBi Q7NL02.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci GVIO251221:GH9A-1338-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7421.

Entry informationi

Entry nameiHISX_GLOVI
AccessioniPrimary (citable) accession number: Q7NL02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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