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Q7NL02

- HISX_GLOVI

UniProt

Q7NL02 - HISX_GLOVI

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei130 – 1301NADUniRule annotation
Binding sitei192 – 1921NADUniRule annotation
Binding sitei215 – 2151NADUniRule annotation
Binding sitei238 – 2381SubstrateUniRule annotation
Metal bindingi260 – 2601ZincUniRule annotation
Binding sitei260 – 2601SubstrateUniRule annotation
Metal bindingi263 – 2631ZincUniRule annotation
Binding sitei263 – 2631SubstrateUniRule annotation
Active sitei328 – 3281Proton acceptorUniRule annotation
Active sitei329 – 3291Proton acceptorUniRule annotation
Binding sitei329 – 3291SubstrateUniRule annotation
Metal bindingi362 – 3621ZincUniRule annotation
Binding sitei362 – 3621SubstrateUniRule annotation
Binding sitei416 – 4161SubstrateUniRule annotation
Metal bindingi421 – 4211ZincUniRule annotation
Binding sitei421 – 4211SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-1338-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:gll1324
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
ProteomesiUP000000557: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Histidinol dehydrogenasePRO_0000135775Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi251221.gvip194.

Structurei

3D structure databases

ProteinModelPortaliQ7NL02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
InParanoidiQ7NL02.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.
PhylomeDBiQ7NL02.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7NL02-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRLITQLSE AQTEIKRIAA RTHSEQVQHQ EATVREILQN VRRQGDEALL
60 70 80 90 100
RYTLEFDQVR LAPGDLVVGA AELDAAYQRV STSLLKAIRL AKQRIEQFHR
110 120 130 140 150
ERICKSWVQF QDRGIVLGRR YTPVDAAGLY IPGGRASYPS SVLMSAIPAV
160 170 180 190 200
VAGVPRIVLV TPPNPEGKIN PAVLVAAQES GVHEIYRIGG AQAIGALTYG
210 220 230 240 250
TRTIAPVSVI AGPGNIYVTL AKKLVYGEVG IDSLAGPSEV LIIADSTANP
260 270 280 290 300
VFLAADMLAQ AEHDSLASAI LITPDGRLAE RTIEAVDRQL ENHPRRTLTE
310 320 330 340 350
KSLANYGLVI VTADLAEAAA LSNLFAPEHL ELEVEDPWEL LEKVRHAGAI
360 370 380 390 400
FLGHATPEAV GDYLAGPSHI LPTSGTARYA SGVGVETFQK CSSLVQYTPQ
410 420 430 440
ALAEVGEAID ALTAAEGLPS HGDSVRLRLQ QYENPHSPTQ QQQEE
Length:445
Mass (Da):48,032
Last modified:December 15, 2003 - v1
Checksum:iE74D1ABE35BBFDC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA. Translation: BAC89265.1.
RefSeqiNP_924270.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC89265; BAC89265; BAC89265.
GeneIDi2598786.
KEGGigvi:gvip194.
PATRICi22042073. VBIGloVio86258_1351.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA. Translation: BAC89265.1 .
RefSeqi NP_924270.1. NC_005125.1.

3D structure databases

ProteinModelPortali Q7NL02.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 251221.gvip194.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC89265 ; BAC89265 ; BAC89265 .
GeneIDi 2598786.
KEGGi gvi:gvip194.
PATRICi 22042073. VBIGloVio86258_1351.

Phylogenomic databases

eggNOGi COG0141.
InParanoidi Q7NL02.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.
PhylomeDBi Q7NL02.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci GVIO251221:GH9A-1338-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7421.

Entry informationi

Entry nameiHISX_GLOVI
AccessioniPrimary (citable) accession number: Q7NL02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 15, 2003
Last modified: November 26, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3