Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q7NKL2

- DUT_GLOVI

UniProt

Q7NKL2 - DUT_GLOVI

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

dut

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 2 (07 Jun 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.UniRule annotation

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei80 – 801SubstrateUniRule annotation

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dUMP biosynthetic process Source: UniProtKB-UniPathway
    2. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciGVIO251221:GH9A-1485-MONOMER.
    UniPathwayiUPA00610; UER00666.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
    Short name:
    dUTPaseUniRule annotation
    Alternative name(s):
    dUTP pyrophosphataseUniRule annotation
    Gene namesi
    Name:dutUniRule annotation
    Ordered Locus Names:glr1465
    OrganismiGloeobacter violaceus (strain PCC 7421)
    Taxonomic identifieri251221 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
    ProteomesiUP000000557: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 147147Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182865Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi251221.glr1465.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7NKL2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni67 – 693Substrate bindingUniRule annotation
    Regioni84 – 863Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the dUTPase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0756.
    HOGENOMiHOG000028968.
    KOiK01520.
    OrthoDBiEOG689HXK.
    PhylomeDBiQ7NKL2.

    Family and domain databases

    Gene3Di2.70.40.10. 1 hit.
    HAMAPiMF_00116. dUTPase_bact.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 1 hit.
    TIGRFAMsiTIGR00576. dut. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7NKL2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPVRVAIQR LAHCFALPTC AHPGDAGLDL FAAHAVPLSI APGRFTRVPT    50
    GIALGLPAGY MAFVQPRSGL AARHGISVLN TPGLIDCGYR GEIQVLLINH 100
    GEVPVVVSRG DRIAQLVVLP VPQVQFVEVS TLESSERQTG SFGSSGY 147
    Length:147
    Mass (Da):15,466
    Last modified:June 7, 2004 - v2
    Checksum:i27730B315D71B34C
    GO

    Sequence cautioni

    The sequence BAC89406.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000045 Genomic DNA. Translation: BAC89406.1. Different initiation.
    RefSeqiNP_924411.1. NC_005125.1.

    Genome annotation databases

    EnsemblBacteriaiBAC89406; BAC89406; BAC89406.
    GeneIDi2598643.
    KEGGigvi:glr1465.
    PATRICi22042377. VBIGloVio86258_1497.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000045 Genomic DNA. Translation: BAC89406.1 . Different initiation.
    RefSeqi NP_924411.1. NC_005125.1.

    3D structure databases

    ProteinModelPortali Q7NKL2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 251221.glr1465.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC89406 ; BAC89406 ; BAC89406 .
    GeneIDi 2598643.
    KEGGi gvi:glr1465.
    PATRICi 22042377. VBIGloVio86258_1497.

    Phylogenomic databases

    eggNOGi COG0756.
    HOGENOMi HOG000028968.
    KOi K01520.
    OrthoDBi EOG689HXK.
    PhylomeDBi Q7NKL2.

    Enzyme and pathway databases

    UniPathwayi UPA00610 ; UER00666 .
    BioCyci GVIO251221:GH9A-1485-MONOMER.

    Family and domain databases

    Gene3Di 2.70.40.10. 1 hit.
    HAMAPi MF_00116. dUTPase_bact.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 1 hit.
    TIGRFAMsi TIGR00576. dut. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7421.

    Entry informationi

    Entry nameiDUT_GLOVI
    AccessioniPrimary (citable) accession number: Q7NKL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 7, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3