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Q7NKL2

- DUT_GLOVI

UniProt

Q7NKL2 - DUT_GLOVI

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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene
dut, glr1465
Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei80 – 801Substrate By similarity

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
  2. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-1485-MONOMER.
UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:dut
Ordered Locus Names:glr1465
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
ProteomesiUP000000557: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 147147Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotationPRO_0000182865Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi251221.glr1465.

Structurei

3D structure databases

ProteinModelPortaliQ7NKL2.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni67 – 693Substrate binding By similarity
Regioni84 – 863Substrate binding By similarity

Sequence similaritiesi

Belongs to the dUTPase family.

Phylogenomic databases

eggNOGiCOG0756.
HOGENOMiHOG000028968.
KOiK01520.
OrthoDBiEOG689HXK.
PhylomeDBiQ7NKL2.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00116. dUTPase_bact.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR00576. dut. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7NKL2-1 [UniParc]FASTAAdd to Basket

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MDPVRVAIQR LAHCFALPTC AHPGDAGLDL FAAHAVPLSI APGRFTRVPT    50
GIALGLPAGY MAFVQPRSGL AARHGISVLN TPGLIDCGYR GEIQVLLINH 100
GEVPVVVSRG DRIAQLVVLP VPQVQFVEVS TLESSERQTG SFGSSGY 147
Length:147
Mass (Da):15,466
Last modified:June 7, 2004 - v2
Checksum:i27730B315D71B34C
GO

Sequence cautioni

The sequence BAC89406.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC89406.1. Different initiation.
RefSeqiNP_924411.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC89406; BAC89406; BAC89406.
GeneIDi2598643.
KEGGigvi:glr1465.
PATRICi22042377. VBIGloVio86258_1497.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC89406.1 . Different initiation.
RefSeqi NP_924411.1. NC_005125.1.

3D structure databases

ProteinModelPortali Q7NKL2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 251221.glr1465.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC89406 ; BAC89406 ; BAC89406 .
GeneIDi 2598643.
KEGGi gvi:glr1465.
PATRICi 22042377. VBIGloVio86258_1497.

Phylogenomic databases

eggNOGi COG0756.
HOGENOMi HOG000028968.
KOi K01520.
OrthoDBi EOG689HXK.
PhylomeDBi Q7NKL2.

Enzyme and pathway databases

UniPathwayi UPA00610 ; UER00666 .
BioCyci GVIO251221:GH9A-1485-MONOMER.

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
HAMAPi MF_00116. dUTPase_bact.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
TIGRFAMsi TIGR00576. dut. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7421.

Entry informationi

Entry nameiDUT_GLOVI
AccessioniPrimary (citable) accession number: Q7NKL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: July 9, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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