Q7NKK4 (DNAA_GLOVI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA

Gene names

Name:	dnaA
Ordered Locus Names:	gll1473

Organism

Gloeobacter violaceus (strain PCC 7421)

Taxonomic identifier

251221 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Gloeobacteria › Gloeobacterales › Gloeobacter

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Cytoplasm
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: InterPro regulation of DNA replication Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA replication origin binding Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 442	442	Chromosomal replication initiator protein DnaA HAMAP MF_00377		PRO_0000114183
Regions
	Nucleotide binding	145 – 152	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7NKK4 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 6993824B92B91B65	FASTA	442	50,134
	10 20 30 40 50 60 METLWDGILS HLKGRLSRPT FETWIKPATA QQFEQDCLII RTPNPFARSW LQQHYAGAIA 70 80 90 100 110 120 QAGEQVIGRP IQVDFIVSEQ SEEALKPVIE REPAPAAPPA NVASLNSKYT FSRFVVGANN 130 140 150 160 170 180 RMAHVAALAV AEMPGCNYNP LFLCGGVGLG KTHLMQAIGH YRLDIDTRTK IAYVSTERFA 190 200 210 220 230 240 NELIEAIRRD AMQTFREHYR RVDLLMIDDI QFIEGKEYTQ EEFFHTFNAL YESGKQIVIA 250 260 270 280 290 300 SDRPPQLIPR LQERLSSRFS MGLITDIQQP DIETRMAILQ KKAEYENMFV PQDVIHHIAS 310 320 330 340 350 360 AYTTNIRELE GALIRAVAYV SISGLPMTVE TISPILSPPR TRGEITDEAI LELVCDELKV 370 380 390 400 410 420 SAEDMRSDSR RRDISQARQL CMYLLRKYTD LSLPKIGQAL GGKDHTTVLY AIDKIEQSKI 430 440 RDPEVQRLLQ RLGNRLEADA RH

References

[1]

"Complete genome structure of Gloeobacter violaceus PCC 7421, a cyanobacterium that lacks thylakoids." Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T., Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M., Tabata S. DNA Res. 10:137-145(2003) [PubMed: 14621292] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7421.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000045 Genomic DNA. Translation: BAC89414.1.
RefSeq	NP_924419.1. NC_005125.1.
3D structure databases
ProteinModelPortal	Q7NKK4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2598651.
GenomeReviews	Gene locus gll1473 in contig BA000045_GR.
NMPDR	fig|251221.1.peg.1473.
PATRIC	22042393. VBIGloVio86258_1505.
Phylogenomic databases
HOGENOM	HBG695666.
OMA	CHTLNAL.
PhylomeDB	Q7NKK4.
ProtClustDB	PRK00149.
Enzyme and pathway databases
BioCyc	GVIO251221:GLL1473-MONOMER.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAA_GLOVI

Accession

Primary (citable) accession number: Q7NKK4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	December 15, 2003
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program