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Q7NK98 (GCH1_GLOVI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:gll1580
OrganismGloeobacter violaceus (strain PCC 7421) [Reference proteome] [HAMAP]
Taxonomic identifier251221 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter

Protein attributes

Sequence length214 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 214214GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_0000119409

Sites

Metal binding1011Zinc By similarity
Metal binding1041Zinc By similarity
Metal binding1721Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7NK98 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 1E5F0C5BDE6B8284

FASTA21424,094
        10         20         30         40         50         60 
MTIAHKDFLP SDWHEDDSAS EAASRNGLDP MMDAVRTLLV GVGEDPERNG LERTPKRVAE 

        70         80         90        100        110        120 
ALKFLTKGYG QSLEELLNGA IFDLGHDELV LVRDIDLFSM CEHHMLPFIG RAHVGYIPDQ 

       130        140        150        160        170        180 
KVVGLSKLAR IVEMYARRLQ VQERLTRQIA EALQEVLQPR GVAVVIEASH MCMVMRGVQK 

       190        200        210 
PNSWTVTSSM VGVFKESQST RQEFLDLIHH KATF 

« Hide

References

[1]"Complete genome structure of Gloeobacter violaceus PCC 7421, a cyanobacterium that lacks thylakoids."
Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T., Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M., Tabata S.
DNA Res. 10:137-145(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7421.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000045 Genomic DNA. Translation: BAC89521.1.
RefSeqNP_924526.1. NC_005125.1.

3D structure databases

ProteinModelPortalQ7NK98.
SMRQ7NK98. Positions 20-208.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING251221.gvip221.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC89521; BAC89521; BAC89521.
GeneID2598546.
KEGGgvi:gvip221.
PATRIC22042617. VBIGloVio86258_1617.

Phylogenomic databases

eggNOGCOG0302.
KOK01495.
OMAYEQIEYA.
OrthoDBEOG6XHC8G.
PhylomeDBQ7NK98.

Enzyme and pathway databases

BioCycGVIO251221:GH9A-1600-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_GLOVI
AccessionPrimary (citable) accession number: Q7NK98
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways