Q7NK94 (NU1C_GLOVI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NAD(P)H-quinone oxidoreductase subunit 1
EC=1.6.5.-

Alternative name(s):
NAD(P)H dehydrogenase I subunit 1
NDH-1 subunit 1
NDH-A

Gene names

Name:	ndhA
Ordered Locus Names:	gll1584

Organism

Gloeobacter violaceus (strain PCC 7421)

Taxonomic identifier

251221 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Gloeobacteria › Gloeobacterales › Gloeobacter

Protein attributes

Sequence length	407 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient By similarity. HAMAP MF_01350
Catalytic activity	NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol. HAMAP MF_01350
Subunit structure	NDH-1 is composed of at least 11 different subunits By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein Potential HAMAP MF_01350.
Sequence similarities	Belongs to the complex I subunit 1 family.

Ontologies

Keywords
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	NAD NADP Plastoquinone
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 407	407	NAD(P)H-quinone oxidoreductase subunit 1 HAMAP MF_01350		PRO_0000240036
Regions
	Transmembrane	28 – 48	21	Helical; Potential
	Transmembrane	96 – 116	21	Helical; Potential
	Transmembrane	127 – 147	21	Helical; Potential
	Transmembrane	175 – 195	21	Helical; Potential
	Transmembrane	203 – 223	21	Helical; Potential
	Transmembrane	267 – 287	21	Helical; Potential
	Transmembrane	309 – 329	21	Helical; Potential
	Transmembrane	347 – 367	21	Helical; Potential
	Transmembrane	374 – 394	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7NK94 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: E0D00450409D18A6	FASTA	407	43,835
	10 20 30 40 50 60 MEGIDLGNAF AQSLSGLGVP ADVARALWLP LPMIVILLTV TVGVIAAVWG ERKWSGMMQQ 70 80 90 100 110 120 RMGPTIIGLG GSIQGAADGV KLLVKEDIIP VKADPWLFTL GPAIVIIPVF FSYLVIPFGQ 130 140 150 160 170 180 GLVLSDITIG IFFIIAVASI SPIGALMAGY ASNNKYALLG GLRAAAQSIS YEIPLALSVL 190 200 210 220 230 240 AIVMMSSSLS TVDIVEQQET LGLFSFFSWN IWRQPIGFVI FLISALAETE RAPFDLPEAE 250 260 270 280 290 300 SELVAGHHTE YTGMKFALFY LSEYANLILA SLIASVLFLG GWSFIVPLEP LAALFGIEAS 310 320 330 340 350 360 NPIFQVVNAL VGISVTILKA TFFVFLAILA RWTLPRVRID QLLDLGWKFL LPVSLFNLLL 370 380 390 400 TAALVLLSNT LKTTLPLYLP LIIFVGLVFV AMSLQKRPAA KPTAARA

References

[1]

"Complete genome structure of Gloeobacter violaceus PCC 7421, a cyanobacterium that lacks thylakoids." Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T., Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M., Tabata S. DNA Res. 10:137-145(2003) [PubMed: 14621292] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7421.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000045 Genomic DNA. Translation: BAC89525.1.
RefSeq	NP_924530.1. NC_005125.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2598550.
GenomeReviews	Gene locus gll1584 in contig BA000045_GR.
NMPDR	fig|251221.1.peg.1584.
PATRIC	22042625. VBIGloVio86258_1621.
Phylogenomic databases
HOGENOM	HBG727670.
OMA	DRPAYDL.
PhylomeDB	Q7NK94.
ProtClustDB	PRK06076.
Enzyme and pathway databases
BioCyc	GVIO251221:GLL1584-MONOMER.
Family and domain databases
HAMAP	MF_01350. NDH1_NuoH. [Tree]
InterPro	IPR001694. NADH_UbQ_OxRdtase_su1/FPO. IPR018086. NADH_UbQ_OxRdtase_su1_CS. [Graphical view]
PANTHER	PTHR11432. Resp_NADH_DH_1. 1 hit.
Pfam	PF00146. NADHdh. 1 hit. [Graphical view]
PROSITE	PS00667. COMPLEX1_ND1_1. 1 hit. PS00668. COMPLEX1_ND1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NU1C_GLOVI

Accession

Primary (citable) accession number: Q7NK94

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	December 15, 2003
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program