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Q7NK22

- PYRF_GLOVI

UniProt

Q7NK22 - PYRF_GLOVI

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF, gll1658
Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity.UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei12 – 121Substrate By similarity
Binding sitei33 – 331Substrate By similarity
Active sitei62 – 621Proton donor By similarity
Binding sitei124 – 1241Substrate By similarity
Binding sitei186 – 1861Substrate By similarity
Binding sitei195 – 1951Substrate By similarity
Binding sitei215 – 2151Substrate; via amide nitrogen By similarity
Binding sitei216 – 2161Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-1679-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:gll1658
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
ProteomesiUP000000557: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Orotidine 5'-phosphate decarboxylaseUniRule annotation
PRO_0000134544Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi251221.gvip232.

Structurei

3D structure databases

ProteinModelPortaliQ7NK22.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni60 – 6910Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
KOiK01591.
OMAiRPITQSA.
OrthoDBiEOG6N6815.
PhylomeDBiQ7NK22.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7NK22-1 [UniParc]FASTAAdd to Basket

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MGGAERVIVA LDLADAQAAR ALVERAPAVR FWKVGLELFT AAGPGLIEWL    50
KARGCRVFLD LKFHDIPNTV AGACRAATRL GVDLLTVHAT GGQPMLMAAV 100
SACTGEAARL GSPAPAVLAV TLLTSLDAQL LEQQLLVNVG VSGYVEHLAV 150
LAVSSGVQGV VCSPLETALL RERCGNDFLI VTPGIRPGGS GEGDQRRTLT 200
PGEAFARGAD YLVVGRPVTT APDPQVAFKA IVAEVGG 237
Length:237
Mass (Da):24,470
Last modified:December 15, 2003 - v1
Checksum:i0959AC5628E8258C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC89599.1.
RefSeqiNP_924604.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC89599; BAC89599; BAC89599.
GeneIDi2598438.
KEGGigvi:gvip232.
PATRICi22042775. VBIGloVio86258_1695.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC89599.1 .
RefSeqi NP_924604.1. NC_005125.1.

3D structure databases

ProteinModelPortali Q7NK22.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 251221.gvip232.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC89599 ; BAC89599 ; BAC89599 .
GeneIDi 2598438.
KEGGi gvi:gvip232.
PATRICi 22042775. VBIGloVio86258_1695.

Phylogenomic databases

eggNOGi COG0284.
KOi K01591.
OMAi RPITQSA.
OrthoDBi EOG6N6815.
PhylomeDBi Q7NK22.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci GVIO251221:GH9A-1679-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7421.

Entry informationi

Entry nameiPYRF_GLOVI
AccessioniPrimary (citable) accession number: Q7NK22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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