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Q7NJV3

- DEF1_GLOVI

UniProt

Q7NJV3 - DEF1_GLOVI

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Protein
Peptide deformylase 1
Gene
def1, glr1729
Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi153 – 1531Iron By similarity
Metal bindingi195 – 1951Iron By similarity
Active sitei196 – 1961 By similarity
Metal bindingi199 – 1991Iron By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-1751-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase 1 (EC:3.5.1.88)
Short name:
PDF 1
Alternative name(s):
Polypeptide deformylase 1
Gene namesi
Name:def1
Ordered Locus Names:glr1729
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
ProteomesiUP000000557: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Peptide deformylase 1UniRule annotation
PRO_0000082785Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi251221.glr1729.

Structurei

3D structure databases

ProteinModelPortaliQ7NJV3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243508.
KOiK01462.
OrthoDBiEOG664CMF.
PhylomeDBiQ7NJV3.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7NJV3-1 [UniParc]FASTAAdd to Basket

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MHLKRAYPKD CLSGVGSNAC RIGDRQSRYP VTIECESTGT SGGGVYEIVK    50
TGDPVLRLTA KPLNSDEIQS EAIQQLIAAM AERMREAPGV GLAAPQVGVS 100
VQLVVIEDRP EYIERLSGAE RREREREPVP FHVLINPVLS VEGEESAVFF 150
EGCLSIPGYQ GLVARARVVR VEALDERAAP VVIRAHGWYA RILQHEIDHL 200
NGLLCVDRMD LQTFSTLENY DRFWRGG 227
Length:227
Mass (Da):25,170
Last modified:December 15, 2003 - v1
Checksum:iCB0A4FE000DC1551
GO

Sequence cautioni

The sequence BAC89670.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC89670.1. Different initiation.
RefSeqiNP_924675.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC89670; BAC89670; BAC89670.
GeneIDi2600131.
KEGGigvi:glr1729.
PATRICi22042901. VBIGloVio86258_1757.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC89670.1 . Different initiation.
RefSeqi NP_924675.1. NC_005125.1.

3D structure databases

ProteinModelPortali Q7NJV3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 251221.glr1729.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC89670 ; BAC89670 ; BAC89670 .
GeneIDi 2600131.
KEGGi gvi:glr1729.
PATRICi 22042901. VBIGloVio86258_1757.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243508.
KOi K01462.
OrthoDBi EOG664CMF.
PhylomeDBi Q7NJV3.

Enzyme and pathway databases

BioCyci GVIO251221:GH9A-1751-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7421.

Entry informationi

Entry nameiDEF1_GLOVI
AccessioniPrimary (citable) accession number: Q7NJV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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