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Q7NJV3

- DEF1_GLOVI

UniProt

Q7NJV3 - DEF1_GLOVI

Protein

Peptide deformylase 1

Gene

def1

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

    Catalytic activityi

    Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

    Cofactori

    Binds 1 Fe2+ ion.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi153 – 1531IronUniRule annotation
    Metal bindingi195 – 1951IronUniRule annotation
    Active sitei196 – 1961UniRule annotation
    Metal bindingi199 – 1991IronUniRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. peptide deformylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciGVIO251221:GH9A-1751-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide deformylase 1UniRule annotation (EC:3.5.1.88UniRule annotation)
    Short name:
    PDF 1UniRule annotation
    Alternative name(s):
    Polypeptide deformylase 1UniRule annotation
    Gene namesi
    Name:def1UniRule annotation
    Ordered Locus Names:glr1729
    OrganismiGloeobacter violaceus (strain PCC 7421)
    Taxonomic identifieri251221 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
    ProteomesiUP000000557: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 227227Peptide deformylase 1PRO_0000082785Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi251221.glr1729.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7NJV3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polypeptide deformylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0242.
    HOGENOMiHOG000243508.
    KOiK01462.
    OrthoDBiEOG664CMF.
    PhylomeDBiQ7NJV3.

    Family and domain databases

    Gene3Di3.90.45.10. 1 hit.
    HAMAPiMF_00163. Pep_deformylase.
    InterProiIPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view]
    PANTHERiPTHR10458. PTHR10458. 1 hit.
    PfamiPF01327. Pep_deformylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004749. Pep_def. 1 hit.
    PRINTSiPR01576. PDEFORMYLASE.
    SUPFAMiSSF56420. SSF56420. 1 hit.
    TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7NJV3-1 [UniParc]FASTAAdd to Basket

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    MHLKRAYPKD CLSGVGSNAC RIGDRQSRYP VTIECESTGT SGGGVYEIVK    50
    TGDPVLRLTA KPLNSDEIQS EAIQQLIAAM AERMREAPGV GLAAPQVGVS 100
    VQLVVIEDRP EYIERLSGAE RREREREPVP FHVLINPVLS VEGEESAVFF 150
    EGCLSIPGYQ GLVARARVVR VEALDERAAP VVIRAHGWYA RILQHEIDHL 200
    NGLLCVDRMD LQTFSTLENY DRFWRGG 227
    Length:227
    Mass (Da):25,170
    Last modified:December 15, 2003 - v1
    Checksum:iCB0A4FE000DC1551
    GO

    Sequence cautioni

    The sequence BAC89670.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000045 Genomic DNA. Translation: BAC89670.1. Different initiation.
    RefSeqiNP_924675.1. NC_005125.1.

    Genome annotation databases

    EnsemblBacteriaiBAC89670; BAC89670; BAC89670.
    GeneIDi2600131.
    KEGGigvi:glr1729.
    PATRICi22042901. VBIGloVio86258_1757.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000045 Genomic DNA. Translation: BAC89670.1 . Different initiation.
    RefSeqi NP_924675.1. NC_005125.1.

    3D structure databases

    ProteinModelPortali Q7NJV3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 251221.glr1729.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC89670 ; BAC89670 ; BAC89670 .
    GeneIDi 2600131.
    KEGGi gvi:glr1729.
    PATRICi 22042901. VBIGloVio86258_1757.

    Phylogenomic databases

    eggNOGi COG0242.
    HOGENOMi HOG000243508.
    KOi K01462.
    OrthoDBi EOG664CMF.
    PhylomeDBi Q7NJV3.

    Enzyme and pathway databases

    BioCyci GVIO251221:GH9A-1751-MONOMER.

    Family and domain databases

    Gene3Di 3.90.45.10. 1 hit.
    HAMAPi MF_00163. Pep_deformylase.
    InterProi IPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view ]
    PANTHERi PTHR10458. PTHR10458. 1 hit.
    Pfami PF01327. Pep_deformylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004749. Pep_def. 1 hit.
    PRINTSi PR01576. PDEFORMYLASE.
    SUPFAMi SSF56420. SSF56420. 1 hit.
    TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7421.

    Entry informationi

    Entry nameiDEF1_GLOVI
    AccessioniPrimary (citable) accession number: Q7NJV3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2003
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3