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Q7NJV3

- DEF1_GLOVI

UniProt

Q7NJV3 - DEF1_GLOVI

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Protein

Peptide deformylase 1

Gene

def1

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe(2+) ion.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi153 – 1531IronUniRule annotation
Metal bindingi195 – 1951IronUniRule annotation
Active sitei196 – 1961UniRule annotation
Metal bindingi199 – 1991IronUniRule annotation

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-1751-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase 1UniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDF 1UniRule annotation
Alternative name(s):
Polypeptide deformylase 1UniRule annotation
Gene namesi
Name:def1UniRule annotation
Ordered Locus Names:glr1729
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
ProteomesiUP000000557: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Peptide deformylase 1PRO_0000082785Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi251221.glr1729.

Structurei

3D structure databases

ProteinModelPortaliQ7NJV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243508.
InParanoidiQ7NJV3.
KOiK01462.
OrthoDBiEOG664CMF.
PhylomeDBiQ7NJV3.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7NJV3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHLKRAYPKD CLSGVGSNAC RIGDRQSRYP VTIECESTGT SGGGVYEIVK
60 70 80 90 100
TGDPVLRLTA KPLNSDEIQS EAIQQLIAAM AERMREAPGV GLAAPQVGVS
110 120 130 140 150
VQLVVIEDRP EYIERLSGAE RREREREPVP FHVLINPVLS VEGEESAVFF
160 170 180 190 200
EGCLSIPGYQ GLVARARVVR VEALDERAAP VVIRAHGWYA RILQHEIDHL
210 220
NGLLCVDRMD LQTFSTLENY DRFWRGG
Length:227
Mass (Da):25,170
Last modified:December 15, 2003 - v1
Checksum:iCB0A4FE000DC1551
GO

Sequence cautioni

The sequence BAC89670.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA. Translation: BAC89670.1. Different initiation.
RefSeqiNP_924675.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC89670; BAC89670; BAC89670.
GeneIDi2600131.
KEGGigvi:glr1729.
PATRICi22042901. VBIGloVio86258_1757.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA. Translation: BAC89670.1 . Different initiation.
RefSeqi NP_924675.1. NC_005125.1.

3D structure databases

ProteinModelPortali Q7NJV3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 251221.glr1729.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC89670 ; BAC89670 ; BAC89670 .
GeneIDi 2600131.
KEGGi gvi:glr1729.
PATRICi 22042901. VBIGloVio86258_1757.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243508.
InParanoidi Q7NJV3.
KOi K01462.
OrthoDBi EOG664CMF.
PhylomeDBi Q7NJV3.

Enzyme and pathway databases

BioCyci GVIO251221:GH9A-1751-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7421.

Entry informationi

Entry nameiDEF1_GLOVI
AccessioniPrimary (citable) accession number: Q7NJV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: November 26, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3