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Q7NJT1 (GLPK_GLOVI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol kinase
EC=2.7.1.30
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK
Gene names
Name:glpK
Ordered Locus Names:gll1751
OrganismGloeobacter violaceus (strain PCC 7421)
Taxonomic identifier251221 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Gloeobacteria › Gloeobacterales › Gloeobacter

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glycerol kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Glycerol kinase HAMAP MF_00186
PRO_0000059457

Regions

Nucleotide binding410 – 4145ATP By similarity

Sites

Binding site211Substrate By similarity
Binding site251ATP By similarity
Binding site881Substrate By similarity
Binding site1401Substrate By similarity
Binding site2441Substrate By similarity
Binding site2661ATP By similarity
Binding site3091ATP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7NJT1 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 3FCC3406FFA9507C

FASTA49753,311
        10         20         30         40         50         60 
MVFASAGAAV SGAILALDLG TTGIRALLFD PSGAVAAGAY REVPQIYPQP GWVEHDPQTI 

        70         80         90        100        110        120 
WQLTCEVVAE VQAQSAARIA AVGLTNQRET CLLWDAATGT PHGNAIVWQD RRTAALCQKL 

       130        140        150        160        170        180 
RAEGWEAPIR QRTGLVIDAY FSATKLAWLL AHRRPYYPGL KAGTIDSWII WKLTGGRVHA 

       190        200        210        220        230        240 
TDTSNASRTM LFNLHTRDWD PELLELLAIP AEILPAIKPS LGVLAETDVR VLGYSAPIAG 

       250        260        270        280        290        300 
ILGDQQAALF AHGCDRPGLV KCTYGTGSFL VAHTGDRPIR SRHQLLTTVA WSDRTSTGYA 

       310        320        330        340        350        360 
LEGALFTTGA SVQWLRDGLG IIETADESEA LAASVPDSGG VYFVPALSGL GAPHWDMGAR 

       370        380        390        400        410        420 
GLLIGLTRGS GRGQIARAVL EAIAFQTREV TDALAADMGT PLTRLKVDGG AVRNNLLMQL 

       430        440        450        460        470        480 
QADVLGVPVE RPQLIDTTAQ GAAFAAGLGT GFWGDYAELV AARPIDRVFE SGERQLVLQA 

       490 
HYAVWQRAVE RSREWVR

« Hide

References

[1]"Complete genome structure of Gloeobacter violaceus PCC 7421, a cyanobacterium that lacks thylakoids."
Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T., Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M., Tabata S.
DNA Res. 10:137-145(2003) [PubMed: 14621292] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7421.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000045 Genomic DNA. Translation: BAC89692.1.
RefSeqNP_924697.1. NC_005125.1.

3D structure databases

ProteinModelPortalQ7NJT1.
SMRQ7NJT1. Positions 14-497.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2600153.
GenomeReviewsGene locus gll1751 in contig BA000045_GR.
NMPDRfig|251221.1.peg.1751.
PATRIC22042951. VBIGloVio86258_1781.

Phylogenomic databases

HOGENOMHBG511469.
OMAEGAIFIT.
PhylomeDBQ7NJT1.

Enzyme and pathway databases

BioCycGVIO251221:GLL1751-MONOMER.

Family and domain databases

HAMAPMF_00186. Glycerol_kin.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. Glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. False negative.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLPK_GLOVI
AccessionPrimary (citable) accession number: Q7NJT1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: December 15, 2003
Last modified: January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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