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Q7NJM6 (PANCY_GLOVI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional pantoate ligase/cytidylate kinase

Including the following 2 domains:

  1. Pantoate--beta-alanine ligase
    EC=6.3.2.1
    Alternative name(s):
    Pantoate-activating enzyme
    Pantothenate synthetase
  2. Cytidylate kinase
    Short name=CK
    EC=2.7.4.14
    Alternative name(s):
    Cytidine monophosphate kinase
    Short name=CMP kinase
Gene names
Name:panC/cmk
Ordered Locus Names:gll1806
OrganismGloeobacter violaceus (strain PCC 7421) [Reference proteome] [HAMAP]
Taxonomic identifier251221 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter

Protein attributes

Sequence length515 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP-Rule MF_00158

ATP + (d)CMP = ADP + (d)CDP. HAMAP-Rule MF_00158

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP-Rule MF_00158

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00158.

Sequence similarities

In the N-terminal section; belongs to the pantothenate synthetase family.

In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 515515Bifunctional pantoate ligase/cytidylate kinase HAMAP-Rule MF_00158
PRO_0000239788

Regions

Nucleotide binding295 – 3039ATP By similarity
Region1 – 279279Pantoate--beta-alanine ligase HAMAP-Rule MF_00158
Region280 – 515236Cytidylate kinase HAMAP-Rule MF_00158

Sequences

Sequence LengthMass (Da)Tools
Q7NJM6 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: A5479BC6A2AE2006

FASTA51556,060
        10         20         30         40         50         60 
MKVVETVARL EAFRRARAPV AGVEMGLVMT MGALHEGHRS LIARARRENT VLVVSIFVNP 

        70         80         90        100        110        120 
TQFGSSEDLS RYPRPLEADL ELCRHEGVDL VFAPPESELY PLGSGTKVVP DPALTEVMCG 

       130        140        150        160        170        180 
LSRPGHFSGV ATVVAKVMNL VQPVRAYFGQ KDAQQVAVIK SVCCDLNIGG RIVVCPTVHD 

       190        200        210        220        230        240 
PDGLALSSRN VYLSSAQRST ALALPRALDK AAHLWAGGER QASELERAVR SVLASEPGLE 

       250        260        270        280        290        300 
IEYVAAVDPE RLAPRQDNAG PVLVAAAVRV GSTRLIDNVV LGQHHERRPI IAIDGPAGAG 

       310        320        330        340        350        360 
KSTLARRLAQ RLGFLYIDTG AMYRAVTWRA MQERIDPLDG ERLSALTRAV RIRLAPGYQS 

       370        380        390        400        410        420 
AFPTRVWVDG EEVTRAVRDE AVSLHVSAVS SHPGVRSELV AQQRRIGEAG GVILDGRDIG 

       430        440        450        460        470        480 
THVFSRAELK IYLTASVEER ALRRADDLKA KGLPVPDIEV LKEQIRSRDN QDMSRAYAPL 

       490        500        510 
RKADDAIEVN TDTFTVQDTL DRLLALYRDK VGGSV 

« Hide

References

[1]"Complete genome structure of Gloeobacter violaceus PCC 7421, a cyanobacterium that lacks thylakoids."
Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T., Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M., Tabata S.
DNA Res. 10:137-145(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7421.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000045 Genomic DNA. Translation: BAC89747.1.
RefSeqNP_924752.1. NC_005125.1.

3D structure databases

ProteinModelPortalQ7NJM6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING251221.gll1806.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC89747; BAC89747; BAC89747.
GeneID2600208.
KEGGgvi:gll1806.
PATRIC22043069. VBIGloVio86258_1840.

Phylogenomic databases

eggNOGCOG0283.
HOGENOMHOG000233355.
KOK13799.
OMALGEKDWQ.
OrthoDBEOG6Z6FZ4.
ProtClustDBPRK13477.

Enzyme and pathway databases

BioCycGVIO251221:GH9A-1829-MONOMER.
UniPathwayUPA00028; UER00005.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00158. PanC.
MF_00238. Cytidyl_kinase_type1.
MF_01349. PanCY.
InterProIPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00017. cmk. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNetSearch...

Entry information

Entry namePANCY_GLOVI
AccessionPrimary (citable) accession number: Q7NJM6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: December 15, 2003
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways