Reviewed, UniProtKB/Swiss-Prot Q7NJM6 (PANCY_GLOVI)

Names and origin

Protein names

Recommended name:
    Bifunctional pantoate ligase/cytidylate kinase
Including the following 2 domains:
    1- Recommended name:
            Pantoate--beta-alanine ligase
              EC=6.3.2.1
        Alternative name(s):
            Pantothenate synthetase
            Pantoate-activating enzyme
    2- Recommended name:
            Cytidylate kinase
                Short name=CK
              EC=2.7.4.14
        Alternative name(s):
            Cytidine monophosphate kinase
              Short name=CMP kinase

Gene names

Name:	panC/cmk
Ordered Locus Names:	gll1806

Organism

Gloeobacter violaceus [Complete proteome] [HAMAP]

Taxonomic identifier

33072 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Gloeobacteria › Gloeobacterales › Gloeobacter

Protein attributes

Sequence length	515 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP MF_01349 ATP + (d)CMP = ADP + (d)CDP. HAMAP MF_01349
Pathway	Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP MF_01349
Subcellular location	Cytoplasm By similarity HAMAP MF_01349.
Sequence similarities	In the N-terminal section; belongs to the pantothenate synthetase family. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Pantothenate biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Ligase Transferase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	pantothenate biosynthetic process Inferred from electronic annotation. Source: HAMAP pyrimidine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP cytidylate kinase activity Inferred from electronic annotation. Source: HAMAP pantoate-beta-alanine ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 515	515	Bifunctional pantoate ligase/cytidylate kinase HAMAP MF_01349		PRO_0000239788
Regions
	Nucleotide binding	295 – 303	9	ATP By similarity
	Region	1 – 279	279	Pantoate--beta-alanine ligase HAMAP MF_01349
	Region	280 – 515	236	Cytidylate kinase HAMAP MF_01349

Sequences

	Sequence		Length	Mass (Da)
	Q7NJM6-1 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: A5479BC6A2AE2006	FASTA	515	56,060
	10 20 30 40 50 60 MKVVETVARL EAFRRARAPV AGVEMGLVMT MGALHEGHRS LIARARRENT VLVVSIFVNP 70 80 90 100 110 120 TQFGSSEDLS RYPRPLEADL ELCRHEGVDL VFAPPESELY PLGSGTKVVP DPALTEVMCG 130 140 150 160 170 180 LSRPGHFSGV ATVVAKVMNL VQPVRAYFGQ KDAQQVAVIK SVCCDLNIGG RIVVCPTVHD 190 200 210 220 230 240 PDGLALSSRN VYLSSAQRST ALALPRALDK AAHLWAGGER QASELERAVR SVLASEPGLE 250 260 270 280 290 300 IEYVAAVDPE RLAPRQDNAG PVLVAAAVRV GSTRLIDNVV LGQHHERRPI IAIDGPAGAG 310 320 330 340 350 360 KSTLARRLAQ RLGFLYIDTG AMYRAVTWRA MQERIDPLDG ERLSALTRAV RIRLAPGYQS 370 380 390 400 410 420 AFPTRVWVDG EEVTRAVRDE AVSLHVSAVS SHPGVRSELV AQQRRIGEAG GVILDGRDIG 430 440 450 460 470 480 THVFSRAELK IYLTASVEER ALRRADDLKA KGLPVPDIEV LKEQIRSRDN QDMSRAYAPL 490 500 510 RKADDAIEVN TDTFTVQDTL DRLLALYRDK VGGSV

References

[1]

"Complete genome structure of Gloeobacter violaceus PCC 7421, a cyanobacterium that lacks thylakoids." Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T., Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M., Tabata S. DNA Res. 10:137-145(2003) [PubMed: 14621292] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7421.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000045 Genomic DNA. Translation: BAC89747.1.
RefSeq	NP_924752.1.
3D structure databases
SMR	Q7NJM6. Positions 1-282, 290-508.
ModBase	Search...
Genome annotation databases
GeneID	2600208.
GenomeReviews	Gene locus gll1806 in contig BA000045_GR.
KEGG	gvi:gll1806.
NMPDR	fig|251221.1.peg.1806.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG428839.
OMA	LGEKDWQ.
Enzyme and pathway databases
BioCyc	GVIO251221:GLL1806-MONOMER.
BRENDA	2.7.4.14. 276183. 6.3.2.1. 276183.
Family and domain databases
HAMAP	MF_01349. PanCY. [Tree]
InterPro	IPR003136. Cytidylate_kin. IPR011994. Cytidylate_kinase_dom. IPR003721. Pantoate_ligase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PANTHER	PTHR21299:SF1. Pantoate_ligase. 1 hit.
Pfam	PF02224. Cytidylate_kin. 1 hit. PF02569. Pantoate_ligase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00017. cmk. 1 hit. TIGR00018. panC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PANCY_GLOVI

Accession

Primary (citable) accession number: Q7NJM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	December 15, 2003
Last modified:	February 9, 2010
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)