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Q7NJM6

- PANCY_GLOVI

UniProt

Q7NJM6 - PANCY_GLOVI

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Protein
Bifunctional pantoate ligase/cytidylate kinase
Gene
panC/cmk, gll1806
Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation
ATP + (d)CMP = ADP + (d)CDP.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi295 – 3039ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. cytidylate kinase activity Source: UniProtKB-HAMAP
  3. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
  2. pyrimidine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Ligase, Transferase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-1829-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional pantoate ligase/cytidylate kinase
Including the following 2 domains:
Pantoate--beta-alanine ligase (EC:6.3.2.1)
Alternative name(s):
Pantoate-activating enzyme
Pantothenate synthetase
Cytidylate kinase (EC:2.7.4.14)
Short name:
CK
Alternative name(s):
Cytidine monophosphate kinase
Short name:
CMP kinase
Gene namesi
Name:panC/cmk
Ordered Locus Names:gll1806
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
ProteomesiUP000000557: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Bifunctional pantoate ligase/cytidylate kinaseUniRule annotation
PRO_0000239788Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi251221.gll1806.

Structurei

3D structure databases

ProteinModelPortaliQ7NJM6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 279279Pantoate--beta-alanine ligaseUniRule annotation
Add
BLAST
Regioni280 – 515236Cytidylate kinaseUniRule annotation
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the pantothenate synthetase family.
In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.

Phylogenomic databases

eggNOGiCOG0283.
HOGENOMiHOG000233355.
KOiK13799.
OMAiLGEKDWQ.
OrthoDBiEOG6Z6FZ4.
PhylomeDBiQ7NJM6.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
MF_00238. Cytidyl_kinase_type1.
MF_01349. PanCY.
InterProiIPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF2. PTHR21299:SF2. 1 hit.
PfamiPF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00017. cmk. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7NJM6-1 [UniParc]FASTAAdd to Basket

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MKVVETVARL EAFRRARAPV AGVEMGLVMT MGALHEGHRS LIARARRENT    50
VLVVSIFVNP TQFGSSEDLS RYPRPLEADL ELCRHEGVDL VFAPPESELY 100
PLGSGTKVVP DPALTEVMCG LSRPGHFSGV ATVVAKVMNL VQPVRAYFGQ 150
KDAQQVAVIK SVCCDLNIGG RIVVCPTVHD PDGLALSSRN VYLSSAQRST 200
ALALPRALDK AAHLWAGGER QASELERAVR SVLASEPGLE IEYVAAVDPE 250
RLAPRQDNAG PVLVAAAVRV GSTRLIDNVV LGQHHERRPI IAIDGPAGAG 300
KSTLARRLAQ RLGFLYIDTG AMYRAVTWRA MQERIDPLDG ERLSALTRAV 350
RIRLAPGYQS AFPTRVWVDG EEVTRAVRDE AVSLHVSAVS SHPGVRSELV 400
AQQRRIGEAG GVILDGRDIG THVFSRAELK IYLTASVEER ALRRADDLKA 450
KGLPVPDIEV LKEQIRSRDN QDMSRAYAPL RKADDAIEVN TDTFTVQDTL 500
DRLLALYRDK VGGSV 515
Length:515
Mass (Da):56,060
Last modified:December 15, 2003 - v1
Checksum:iA5479BC6A2AE2006
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC89747.1.
RefSeqiNP_924752.1. NC_005125.1.
WP_011141804.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC89747; BAC89747; BAC89747.
GeneIDi2600208.
KEGGigvi:gll1806.
PATRICi22043069. VBIGloVio86258_1840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC89747.1 .
RefSeqi NP_924752.1. NC_005125.1.
WP_011141804.1. NC_005125.1.

3D structure databases

ProteinModelPortali Q7NJM6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 251221.gll1806.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC89747 ; BAC89747 ; BAC89747 .
GeneIDi 2600208.
KEGGi gvi:gll1806.
PATRICi 22043069. VBIGloVio86258_1840.

Phylogenomic databases

eggNOGi COG0283.
HOGENOMi HOG000233355.
KOi K13799.
OMAi LGEKDWQ.
OrthoDBi EOG6Z6FZ4.
PhylomeDBi Q7NJM6.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci GVIO251221:GH9A-1829-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
MF_00238. Cytidyl_kinase_type1.
MF_01349. PanCY.
InterProi IPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF2. PTHR21299:SF2. 1 hit.
Pfami PF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00017. cmk. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7421.

Entry informationi

Entry nameiPANCY_GLOVI
AccessioniPrimary (citable) accession number: Q7NJM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: December 15, 2003
Last modified: September 3, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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