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Q7NIM7

- RBL_GLOVI

UniProt

Q7NIM7 - RBL_GLOVI

Protein

Ribulose bisphosphate carboxylase large chain

Gene

cbbL

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site.UniRule annotation

    Catalytic activityi

    2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
    3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei122 – 1221Substrate; in homodimeric partnerUniRule annotation
    Binding sitei172 – 1721SubstrateUniRule annotation
    Active sitei174 – 1741Proton acceptorUniRule annotation
    Binding sitei176 – 1761SubstrateUniRule annotation
    Metal bindingi200 – 2001Magnesium; via carbamate groupUniRule annotation
    Metal bindingi202 – 2021MagnesiumUniRule annotation
    Metal bindingi203 – 2031MagnesiumUniRule annotation
    Active sitei293 – 2931Proton acceptorUniRule annotation
    Binding sitei294 – 2941SubstrateUniRule annotation
    Binding sitei326 – 3261SubstrateUniRule annotation
    Sitei333 – 3331Transition state stabilizerUniRule annotation
    Binding sitei378 – 3781SubstrateUniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. monooxygenase activity Source: UniProtKB-KW
    3. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. photorespiration Source: UniProtKB-KW
    2. reductive pentose-phosphate cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase, Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Calvin cycle, Carbon dioxide fixation, Photorespiration, Photosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciGVIO251221:GH9A-2182-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribulose bisphosphate carboxylase large chainUniRule annotation (EC:4.1.1.39UniRule annotation)
    Short name:
    RuBisCO large subunitUniRule annotation
    Gene namesi
    Name:cbbLUniRule annotation
    Synonyms:rbcLUniRule annotation
    Ordered Locus Names:glr2156
    OrganismiGloeobacter violaceus (strain PCC 7421)
    Taxonomic identifieri251221 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
    ProteomesiUP000000557: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 474474Ribulose bisphosphate carboxylase large chainPRO_0000062623Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei200 – 2001N6-carboxylysineUniRule annotation
    Disulfide bondi246 – 246Interchain; in linked formUniRule annotation

    Post-translational modificationi

    The disulfide bond which can form in the large chain dimeric partners within the hexadecamer appears to be associated with oxidative stress and protein turnover.UniRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ7NIM7.

    Interactioni

    Subunit structurei

    Heterohexadecamer of 8 large chains and 8 small chains; disulfide-linked. The disulfide link is formed within the large subunit homodimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi251221.gvip295.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7NIM7.
    SMRiQ7NIM7. Positions 8-474.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RuBisCO large chain family. Type I subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1850.
    KOiK01601.
    OMAiFTQDWAS.
    OrthoDBiEOG6ZKXMS.
    PhylomeDBiQ7NIM7.

    Family and domain databases

    Gene3Di3.20.20.110. 1 hit.
    3.30.70.150. 1 hit.
    HAMAPiMF_01338. RuBisCO_L_type1.
    InterProiIPR020878. RuBisCo_large_chain_AS.
    IPR020888. RuBisCO_lsu.
    IPR000685. RuBisCO_lsu_C.
    IPR017443. RuBisCO_lsu_fd_N.
    IPR017444. RuBisCO_lsu_N.
    [Graphical view]
    PfamiPF00016. RuBisCO_large. 1 hit.
    PF02788. RuBisCO_large_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF51649. SSF51649. 1 hit.
    SSF54966. SSF54966. 1 hit.
    PROSITEiPS00157. RUBISCO_LARGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7NIM7-1 [UniParc]FASTAAdd to Basket

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    MSYTKTQAKA GYQAGVKDYR LTYYTPDYTP KDTDVLAAFR VTPQPGVPIE    50
    EAGAAVAAES STGTWTTVWT DGLTELDRYK GRCYDIEPVP GEDNQWICYI 100
    AYPLDLFEEG SVTNVLTSLV GNVFGFKALR ALRLEDIRFP IALVKTYQGP 150
    PHGIVVERDK INKYGRPLLG CTIKPKLGLS AKNYGRAVYE CLRGGLDFTK 200
    DDENINSQPF MRWRDRFLFV QDAIVKSQAE TGEIKGHYLN CTAGTCEEMM 250
    ERAEFAKELK TPIIMHDYLT GGFTANTTLA KWCRRNGILL HIHRAMHAVI 300
    DRQKNHGIHF RVLAKCLRLS GGDHIHTGTV VGKLEGERAS TMGFVDLLRE 350
    EHVERDLSRG IYFTQDWASM PGVMAVASGG IHVWHMPALL DIFGDDAVLQ 400
    FGGGTLGHPW GNAPGATANR VALEACVKAR NEGRDLMREA GDIIREAARW 450
    SPELAAACEL WKEIKFEYEA VDKL 474
    Length:474
    Mass (Da):52,855
    Last modified:December 15, 2003 - v1
    Checksum:i6474FEF981055201
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000045 Genomic DNA. Translation: BAC90097.1.
    RefSeqiNP_925102.1. NC_005125.1.

    Genome annotation databases

    EnsemblBacteriaiBAC90097; BAC90097; BAC90097.
    GeneIDi2600557.
    KEGGigvi:gvip295.
    PATRICi22043775. VBIGloVio86258_2190.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000045 Genomic DNA. Translation: BAC90097.1 .
    RefSeqi NP_925102.1. NC_005125.1.

    3D structure databases

    ProteinModelPortali Q7NIM7.
    SMRi Q7NIM7. Positions 8-474.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 251221.gvip295.

    Proteomic databases

    PRIDEi Q7NIM7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC90097 ; BAC90097 ; BAC90097 .
    GeneIDi 2600557.
    KEGGi gvi:gvip295.
    PATRICi 22043775. VBIGloVio86258_2190.

    Phylogenomic databases

    eggNOGi COG1850.
    KOi K01601.
    OMAi FTQDWAS.
    OrthoDBi EOG6ZKXMS.
    PhylomeDBi Q7NIM7.

    Enzyme and pathway databases

    BioCyci GVIO251221:GH9A-2182-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.110. 1 hit.
    3.30.70.150. 1 hit.
    HAMAPi MF_01338. RuBisCO_L_type1.
    InterProi IPR020878. RuBisCo_large_chain_AS.
    IPR020888. RuBisCO_lsu.
    IPR000685. RuBisCO_lsu_C.
    IPR017443. RuBisCO_lsu_fd_N.
    IPR017444. RuBisCO_lsu_N.
    [Graphical view ]
    Pfami PF00016. RuBisCO_large. 1 hit.
    PF02788. RuBisCO_large_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51649. SSF51649. 1 hit.
    SSF54966. SSF54966. 1 hit.
    PROSITEi PS00157. RUBISCO_LARGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7421.

    Entry informationi

    Entry nameiRBL_GLOVI
    AccessioniPrimary (citable) accession number: Q7NIM7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric "cap" on each end of the "barrel".UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3